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Influence of Acupuncture on Microcirculation Perfusion of Pericardium Meridian and Heart in acute myocardial ischemia Model Rats

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Chinese Journal of Integrative Medicine 2022年第1期28卷 69-75页

作者： ZHUANG Yi ZHOU Jie ZHOU Yu-mei CHEN Jiao WU Ping LYU Pei-ran WAN Min LUO Liao-jun CAI Ding-jun LIANG Fan-rong College of Acupuncture Moxibustion and TuinaChengdu University of Traditional Chinese MedicineChengdu(610075)China College of Acupuncture Moxibustion and TuinaNanjing University of Chinese MedicineNanjing(210023)China Department of Acupuncture and Moxibustion Xin Du Hospital of Traditional Chinese MedicineChengdu(610599)China The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine ShenzhenGuangdong Province(518005)China

Objective: To observe the influence of acupuncture on microcirculation perfusion of the pericardium meridian and heart in acute myocardial ischemia(AMI) rats and evaluate whether acupuncture can simultaneously affect the meridians and corresponding viscera. Additionally, acupoints at different meridians were compared and whether they exert the same effects was discussed. Methods: Totally 32 Sprague-Dawley rats were subjected to left anterior descending(LAD) ligation to develop an AMI *** were divided into 4 groups, including AMI, acupuncture Neiguan(PC 6), Lieque(LU 7) and Qiansanli(LI 10) groups(n=8). Eight rats received only thoracotomy(sham-operated group). The rats in the acupuncture groups received manual acupuncture at PC 6, LU 7 and LI 10 acupoints for 15 min, respectively. The microcirculation perfusion of pericardium meridian and heart was monitored by laser speckle perfusion imager(LSPI) before, during and after acupuncture manipulation for 15 min. Subsequently, the perfusion unit(PU)was calculated and analyzed by PSI System. Results: After LAD, compared to pre-acupuncture stage, the heart microcirculation perfusion(HMP) in the AMI group decreased continuously at during-acupuncture(P>0.05) and post-acupuncture stages(P0.05). Compared to pre-acupuncture stage, the PMP and HMP in PC 6 group significantly increased during acupuncture manipulation(both P0.05);however, they were significantly reduced after acupuncture manipulation(both P<0.05). Additionally, HMP of LI 10 group was decreased significantly during acupuncture, especially compared to pre-acupuncture stage(P<0.05). Conclusions: Acupuncture at PC 6 obviously increased the PMP and HMP in AMI rats, and the effects were superior to at LU 7 and LI 10 acup

关键词： microcirculation perfusion acupuncture pericardium meridian heart acute myocardial ischemia

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Gualou-Xiebai-Banxia decoction protects against type Ⅱ diabetes with acute myocardial ischemia by attenuating oxidative stress and apoptosis via PI3K/Akt/eNOS signaling

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Chinese Journal of Natural Medicines 2021年第3期19卷 161-169页

作者： FU Yao ZHOU Ji-Dong SANG Xiao-Yu ZHAO Qi-Tao School of Pharmaceutical Sciences Shandong University of Traditional Chinese MedicineJinan 250355China School of Basic Medicine Shandong University of Traditional Chinese MedicineJinan 250355China

Gualou-Xiebai-Banxia decoction has a long history of medical use for treating cardiovascular diseases in *** this study,we investigated the protective effect and underlying mechanisms GXB in typeⅡdiabetes with acute myocardial ischemia(T2DM-AMI)*** hypothesized that GXB may display its protective effect on T2DM-AMI by reducing endothelial progenitor cells(EPCs)apoptosis via activating PI3K(phosphatidyl inositol 3-kinase)/Akt(serine/threonine protein kinase B)/e NOS(endothelial nitric oxide synthase)*** were challenged with a high-fat diet and intraperitoneal injection of streptozotocin to induce a model of typeⅡdiabetes mellitus(T2DM)and coronary ligation to induce acute myocardial infarction(AMI).Changes in metabolites were assessed via enzyme-linked immunoassay and biochemical *** number and apoptosis rate of EPCs in peripheral blood were detected by flow *** m RNAs and proteins in EPCs were analyzed by RT-PCR and Western blot *** results demonstrated that GXB treatment decreased T2DM-AMI-associated changes in plasma fasting blood glucose,muscular enzymes,and blood lipids,and reduced oxidative ***,EPC apoptosis was increased in T2DM-AMI rats and was associated with decreased m RNA and protein levels of PI3K,Akt,and eNOS compared to the ***,T2DM-AMI rats treated with GXB exhibited more circulating EPCs and downregulated levels of cell apoptosis,combined with increased m RNA and protein levels of PI3 K,Akt,and eNOS compared to those of untreated T2DM-AMI *** study showed that GXB treatment mitigated EPC apoptosis and promoted PI3K/Akt/eNOS signaling in T2DM-AMI rats.

关键词： Gualou-Xiebai-Banxia decoction Endothelial progenitor cells Type 2 diabetes acute myocardial ischemia PI3K/Akt/eNOS

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Hawthorn Leaves Flavonoids Decreases Inflammation Related to acute myocardial ischemia/Reperfusion in Anesthetized Dogs

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Chinese Journal of Integrative Medicine 2013年第8期19卷 582-588页

作者： Jian-hua Fu 付建华 (11250) Yong-qiu Zheng 郑咏秋 (11250) Peng Li 李鹏 (11250) Xin-zhi Li 李欣志 (11250) Xiao-hong Shang 尚晓泓 (11250) Jian-xun Liu 刘建勋 (11250) 11250. Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China

Objective： To investigate the effects and mechanisms of hawthorn leaves flavonoids （HLF） on acute myocardial ischemiaJreperfusion in anesthetized dogs. Methods： The acute ischemia models were prepared by ligating left anterior descending （LAD） artery for 60 min. Qualified 15 male dogs were randomly divided into 3 groups with 5 in each group： blank control （treated with normal saline 3 mL/kg） group, HLF low dosage （5 mg/kg） group and high dosage （10 mg/kg） group, with an once injection through a femoral vein 5 min before reperfusion. Epicardial electrocardiogram was adopted to measure the scope and degree of myocardial ischemia. Simultaneously, neutrophil infiltration in infarct （Inf） and remote site （RS） of myocardial tissue was measured by myeloperoxidase （MPO） activity assay. The serum interleukin-1 （IL-1） and tumor necrosis factor~ （TNF-~） content were quantified by radioimmuno-assay. Furthermore, expression of G protein-coupled receptor kinase 2 （GRK2） and nuclear factor K B （NF- K B） in Inf and RS tissue were detected by Western blotting technique. Results： ischemia and reperfusion increased the MPO activity and IL-1 and TNF-~ content. HLF （10 and 5 mg/kg） could significantly decrease the degree and scope of myocardial ischemia; markedly inhibit the increase of MPO activity, and IL-1 and TNF-o~ content induced by myocardial ischemia/infarction. Furthermore, HLF increased GRK2 expression and inhibited NF- K B expression in Inf tissue. Conclusion： HLF could improve the situation of acute myocardial ischemia and inhibit the inflammation in anesthetized dogs, which might be due to its increasing effect on the GRK2 and NF- K B expressions.

关键词： hawthorn leaves flavonoids acute myocardial ischemia reperfusion inflammation G protein-coupled receptor kinase 2

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Experimental Study of the Effect of Autonomic Nervous System on the Transmural Dispersion of Ventricular Repolarization under acute myocardial ischemia in Vivo

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第2期22卷 96-99页

作者： ZHANG Cuntai(张存泰) XU Dawen(徐大文) LI Yang(李泱) LIU Nian(刘念) ZHONG Jianghua(钟江华) WANG Lin(王琳) LU Zaiying(陆再英) Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030

Summary: The effect of the autonomic nerves on the transmural dispersion of ventricular repolarization (TDR) under acute myocardial ischemia in intact canine was investigated. Using the monophasic action potential (MAP) recording technique, MAPs of the epicardium (Epi), midmyocardium (Mid) and endocardium (Endo) were recorded simultaneously by specially designed plunge-needle electrodes at the left ventricular free wall under acute myocardial ischemia in 12 open-chest dogs. MAPD 90 and TDR among three myocardial layers as well as the incidence of the early afterdepolarization (EAD) before autonomic nervous stimulation and during autonomic nervous stimulation were compared. It was found that 10 min after acute myocardial ischemia, TDR was increased from 55±8 ms to 86±15 ms during sympathetic stimulation (P0.05). The EAD was elicited in the Mid of 2 dogs (16 %) 10 min after acute myocardial ischemia, but the EAD were elicited in the Mid of 7 dogs (58 %) during sympathetic stimulation (Pacute myocardial ischemia, which provide the opportunity for the ventricular arrhythmia developing; (2) Parasympathetic stimulation has no significant effect on the transmural dispersion of repolarization under myocardial ischemia.

关键词： autonomic nervous system acute myocardial ischemia monophasic action potential transmural dispersion of repolarization early afterdepolarization

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Metabolic risk factors associated with sudden cardiac death(SCD)during acute myocardial ischemia

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Forensic Sciences Research 2017年第3期2卷 126-131页

作者： Dian Wang Xingxing Wang Jiayan Wu Ruibing Su Jing Kong Xiaojun Yu Department of Forensic Medicine Shantou University Medical CollegeShantouChina

Sudden cardiac death(SCD)is the leading cause of death *** ischemia(MI)is the most common underlying causal disorder for *** risks leading to SCD during acute MI are still not fully ***,using tissue metabolomics,we aimed to investigate myocardial metabolic alterations relevant to SCD events in an acute MI rat model induced by coronary artery ligation(CAL).Thirty-four rats were successfully performed CAL,of which 13 developed lethal ventricular tachyarrhythmia(LVTA)-SCD and 7 developed severe atrioventricular block(AB)-*** rats that survived within 70 min after the ligation were served as peer *** partial least squares-discriminant analysis plots demonstrated clear separations between the SCD rats and controls,indicating obvious differences in myocardial metabolome between these *** levels of isoleucine,lactate,glutamate choline,phosphorylcholine,taurine and asparagine in ischemic myocardia were positively associated with LVTA-SCD events;in contrast,the levels of alanine,urea,phenylalanine,linoleic acid,elaidic acid and stearic acid were inversely correlated with LVTA-SCD *** levels of glutamate and urea were positively and negatively relevant to AB-SCD events,*** dangerous metabolites indicated that lower levels of energy substrates,severe hypoxia,the inhibition of transamination and hyper sympathetic excitement and reactive oxygen species in myocardia were vulnerable to SCD during acute *** results suggest fatal metabolic alterations correlated with SCD events during acute MI,which could offer novel clues for the prevention or treatment of acute MI-related SCD.

关键词： Forensic science forensic pathology sudden cardiac death acute myocardial ischemia tissue metabolomics metabolic risk

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Effects of Corocalm (Shuguan Capsule,疏冠胶囊) on acute myocardial ischemia in Anesthetized Dogs

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Chinese Journal of Integrative Medicine 2007年第3期13卷 206-210页

作者：刘建勋李欣志丛伟红付建华尚晓泓 Fundamental Medical Sciences Center Xiyuan Hospital China Academy of Chinese Medical Sciences

Objective： To investigate the effects of Corocalm （Shuguan Capsule, 疏冠胶囊） on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism. Methods： The acute ischemia model was established by ligating the left anterior descending （LAD） artery. Twenty- five dogs were randomly divided into 5 groups （5 dogs in each group）： the control group （treated with normal saline 3 mL/kg）, the refined Guanxin Capsule group （精制冠心胶囊, GXC 200 mg/kg）, high and low dose Corocalm groups （48.5 mg/kg for low dose group and 194.0 mg/kg for high dose group） and the Diltiazem group （5 mg/kg）. The animals were treated via a single duodenal administration after the model was established. The experiments used epicardial electrocardiogram （EECG） to measure the scope and degree of myocardial ischemia. Simultaneously, the coronary blood flow （CBF） and serum activity levels of creatine phosphokinase （CK） and lactate dehydrogenase （LDH） were measured by electromagnetic flow meter and automatic biochemical analyzer respectively. The plasma endothelin （ET） content was quantified by radioimmunoassay. Results： Corocalm （48.5 mg/kg and 194.0 mg/kg） significantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction. Conclusion： Corocalm could improve the state of acute myocardial ischemia and infarction in dogs. The mechanism of action might be correlated to increasing CBF, inhibiting CK and LDH activities and preventing ET release.

关键词： Corocalm (Shuguan Capsule) acute myocardial ischemia coronary blood flow endothelin mongrel dog

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Cardio-protective Effects of Corocalm (疏冠胶囊) on acute myocardial ischemia/Reperfusion Injury in Rats

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Chinese Journal of Integrative Medicine 2006年第3期12卷 199-202页

作者：刘建勋李欣志马晓斌林成仁王杨慧马雪瑛王敏 Fundamental Medical Sciences Center Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing (100091)

Objective： To investigate the cardio-protective effects of Corocalm （疏冠胶囊） on acute myocardial ischemia in rats, and to explore its possible therapeutic mechanisms. Methods： The acute ischemic model was prepared by ligating the left anterior descending （LAD） coronary artery in rats. The animals were divided into 6 groups, 8 in each group. The sham operated group underwent heart exposure without ligation and were treated with normal saline 3 ml/kg, while the other 5 groups, the model groups, consisted of acceptable acute ischemic model rats and were also treated with normal saline, with the Guanxin Capsule （冠心胶囊, GXC） group treated with refined GXC, 600 mg/kg, the low and high dose Corocalm groups treated with 85 mg/kg and 340 mg/kg of Corocalm respectively, and the Diltiazem group, treated with Diltiazem 5 mg/kg, with all the tested drugs prepared with normal saline into equal volume （ 3 ml/kg） and administrated once via duodenum 10 rain before ligation. myocardial infarction area was determined by the quantitative histological assay with nitroblue tetrazolium （N-BT） stain. And the levels of creatine phosphokinase （CK）, lactate dehydrogenase （LDH）, malondialdehyde （MDA） content, and the activity of superoxide dismutase （SOD） in serum were measured by biochemical assay and spectrophotometry respectively. Besides, the blood viscosity in another 50 rats was determined, who received for 7 successive days oral administration with different concentration of Corocalm or aspirin. Results： It showed that low and high dose Corocalm could significantly reduce the infarction area, inhibit the increase of serum OK, LDH activity and MDA content, and enhance the SOD activity after ischemia/reperfusion. The whole blood viscosity at different shear rates in rats treated with high dose Corocalm was significantly lower than those treated with normal saline （P 0.05）. Conclusion： Corocalm has favourable protective effects on heart in ischemic condition, the effect of which might be thr

关键词： Corocalm acute myocardial ischemia oxygen free radicals blood viscosity rats

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Electroacupuncture modulates the activity of the hippocampus-nucleus tractus solitarius-vagus nerve pathway to reduce myocardial ischemic injury

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Neural Regeneration Research 2018年第9期13卷 1609-1618页

作者： Shuai Cui Kun Wang Sheng-Bing Wu Guo-Qi Zhu Jian Cao Yi-Ping Zhou Mei-Qi Zhou Research Institute of Acupuncture and Meridian Anhui University of Chinese Medicine Clinical Medical College of Acupuncture Moxibustion and RehabilitationGuangzhou University of Chinese Medicine Key Laboratory of Xin' An Medicine Ministry of EducationAnhui University of Chinese Medicine Department of Science and Technology Anhui University of Chinese Medicine

The hippocampus is involved in the regulation of the autonomic nervous system,together with the hypothalamus and brainstem nuclei,such as the paraventricular nucleus and nucleus tractus *** vagus nerve-nucleus tractus solitarius pathway has an important role in cardiovascular reflex *** ischemia has been shown to cause changes in the autonomic nervous system,affecting the dynamic equilibrium of the sympathetic and vagal ***,it remains poorly understood how the hippocampus communicates with brainstem nuclei to regulate the autonomic nervous system and alleviate myocardial ischemic tissue damage.A rat model of acute myocardial ischemia（AMI） was made by ligating the left anterior descending branch of the coronary *** days before ischemia,the hippocampal CA1 region was ***,3 days after ischemia,electroacupuncture（EA） at Shenmen（HT7）-Tongli（HT5） was performed（continuous wave,1 m A,2 Hz,duration of 30 minutes）.Cluster analysis of firing patterns showed that one type of neuron was found in rats in the sham and AMI *** types of neurons were observed in the AMI ＋ EA *** types of neurons were found in the AMI ＋ EA ＋ Lesion *** analysis showed that the frequency of vagus nerve discharge in each group was negatively correlated with heart rate（HR）（P 〈 0.05,r =-0.424）,and positively correlated with mean arterial pressure（MAP）（P 〈 0.05,r = 0.40987） and the rate-pressure product（RPP）（P 〈 0.05,r = 0.4252）.The total frequency of the nucleus tractus solitarius discharge in each group was positively correlated with vagus nerve discharge（P 〈 0.01,r = 0.7021）,but not with hemodynamic index（HR： P 〉 0.05,r =-0.03263; MAP： P 〉 0.05,r =-0.08993; RPP： P 〉 0.05,r =-0.03263）.Some neurons（Neuron C） were negatively correlated with vagus nerve discharge,HR,MAP and RPP in the AMI ＋ EA group（vagus nerve discharge： P 〈 0.05,r =-0.87749; HR： P 〈 0.01,r =-0.91902; MAP： P 〈 0.05,r =-0.85691; RPP： P 〈 0.01,r =-0.91902）

关键词： nerve regeneration acute myocardial ischemia hippocampus nucleus tractus solitarius vagus nerve discharge electroacupuncture Shenmen (HT7) Tongli (HTS) autonomic nerve neural regeneration

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Effect of Electroacupuncture on Reperfusion Ventricular Arrhythmia in Rat

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第3期26卷 269-271,277页

作者：曾青李熳欧阳兴飚农艺刘晓春施静关新民 Department of Neurobiology Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030

Protective effect and mechanism of electroacupuncture （EA） on acute reperfusion ventricular arrhthmia was investigated. Ventricular arrhythmia was induced by occlusion of the proximal left anterior descend （LAD） branch of coronary artery for 5 min and followed with 15 min reperfusion . EA on acupoint ＂Neiguan＂, ＂Jianshi＂ was performed at 30 min before ligation and continued another 5 min during ischemia. Isoprenaline （20, 30 and 50 μg/kg） or atropine （1 mg/ kg） was intravenously injected at 5min before ischemia. The results showed that EA significantly decreased the incidence of ischemia/reperfusion （I/R） induced ventricular tachycardia （VT）, ventricular fibrillation （VF） and mortality as compared to I/R group. Atropine partially suppressed the EA＇s effect of antiarrhythmia; Isoprenaline increased the incidence and severity of reperfusion arrhythmia, which was inhibited by EA, but this inhibition of EA was blocked with increasing dose of isoprenaline. The results indicated that EA treatment could prevent the occurrence of reperfusion ventricular arrhythmia in rats with myocardial ischemia, and its mechanism might be related to the regulation of EA on the β-adrenoceptors and M-cholinergic receptor activation in myocardium.

关键词： acute myocardial ischemia ventricular arrhythmia electroacupuncture β-adrenoceptors M-cholinergic receptor

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Rapid expression of vascular endothelial growth factor in early acutemyocardial ischemia in rats

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Chinese Medical Journal 1999年第8期 86-88页

作者：陈建国徐小虎吴贤英祝家镇

Objective To study the expression of vascular endothelial growth factor(VEGF) in different parts of heart during early acute myocardial ischemia Methods The expression of VEGF in control and study group in rats was performed with the Strept Avidin Biotin Peroxidase Complex (SABC) method Results A rapid expression of VEGF in ischemic areas was observed 1 hour after the ligation of rat left anterior descending (LAD) coronary artery, and in peri ischemic and non ischemic areas 3 hours after ischemia The grade of expression of VEGF increased with the continuation of myocardial ischemia, the positive myocytes of SABC VEGF staining mainly localized in peri ischemic areas 5 hours after ischemia No expression of VEGF in control group was found Conclusion The expression of VEGF may be up regulated in rapid and continuous manner with characteristic spatial and temporal kinetic during early acute myocardial ischemia

关键词： acute myocardial ischemia vascular endothelial growth factor immunohistochemistry

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