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PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss

Neural Regeneration Research 2023年第7期18卷 1601-1606页

作者： Bei Fan Fei Lu Wei-Jia Du Jun Chen Xiao-Gang An Ren-Feng Wang Wei Li Yong-Li Song Ding-Jun Zha Fu-Quan Chen Department of Otolaryngology Head and Neck Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Studies have shown that phosphatase and tensin homolog deleted on chromosome ten(PTEN)participates in the regulation of cochlear hair cell survival.Bisperoxovanadium protects against neurodegeneration by inhibiting PTEN expression.However,whether bisperoxovanadium can protect against noise-induced hearing loss and the underlying mechanism remains unclear.In this study,we established a mouse model of noise-induced hearing loss by exposure to 105 dB sound for 2 hours.We found that PTEN expression was increased in the organ of Corti,including outer hair cells,inner hair cells,and lateral wall tissues.Intraperitoneal administration of bisperoxovanadium decreased the auditory threshold and the loss of cochlear hair cells and inner hair cell ribbons.In addition,noise exposure decreased p-PI3K and p-Akt levels.Bisperoxovanadium preconditioning or PTEN knockdown upregulated the activity of PI3K-Akt.Bisperoxovanadium also prevented H_(2)O_(2)-induced hair cell death by reducing mitochondrial reactive oxygen species generation in cochlear explants.These findings suggest that bisperoxovanadium reduces noise-induced hearing injury and reduces cochlear hair cell loss.

关键词： acoustic trauma Akt oxidative stress bisperoxovanadium cochlear hair cells loss inner hair cell ribbons loss noise exposure permanent threshold shift phosphatase and tensin homologue deleted on chromosome ten phosphatidylinositol 3 kinase siPTEN

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Tinnitus and hyperacusis in children: clinic reports and basic research

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Journal of Otology 2012年第1期7卷 15-18页

作者： NIU Yu-guang Lauren Doolittle WANG Rong-guang SUN Wei The Department of Otolaryngology Chinese PLA General Hospital Beijing 100853 28 Fuxing RoadBeijing P.R. China Center for Hearing and Deafness Department of Communicative Disorders and SciencesState University of New York at Buffalo Buffalo 14214 NY USA

Objective Tinnitus and hyperacusis are subjective symptoms which can be reponeu tJy p^t, lJ ： age. Although tinnitus and hyperacusis can have a negative effect on child development, these symptoms are commonly overlooked by their parents and clinicians. In this paper, we review clinical reports on tinnitus and hyperacusis in children and basic scientific studies on these disorders in order to provide updates of these disorders in the pediatric population. Recent studies have found that tinnitus and hyperacusis are not uncommon in children, especially in those with conductive and sensorineural hearing loss. The parents and clinicians should pay attention when children show abnormal behaviors and especially when they develop hearing loss. Since there is no objective measurement for tinnitus and hyperacusis, the diagnosis in children can be challenging. Tinnitus and hyperacusis are also common in Williams syndrome and autism but the mechanisms are still not clear. High doses of salicylate and noise exposure can in- duce tinnitus. Animal studies have determined lack of inhibition in the auditory cortex and the inferior colliculus may be critical for tinnitus and hyperacusis generation. The non-classic auditory system may also be involved in the aware- ness and tolerance of tinnitus and hyperacusis.

关键词： tinnitus hyperacusis auditory system salicylate acoustic trauma

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Noise Exposure and Its Auditory Effect on Industrial Workers

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第5期10卷 365-375页

作者： Ifeoluwa Victor Owolawi Clinical Audiology and Hearing Therapy School of Advanced Education Research and Accreditation (SAERA) Valencia Spain

This paper analyzes the effect of exposure to noise among industrial workers in Nigeria to discover the level of exposure to noise that causes auditory defects or noise-induced hearing loss (NIHL), this paper primarily covers the evaluation of hearing impairment and its severity on exposure to loud sounds (acoustic trauma) and the role of hearing protective devices for industrial workers for prevention of Noise Induced Hearing Loss (NIHL). The paper also discusses the findings and guides as preventive methods for such industries. A total sample of seventy (70) workers were selected from three (3) manufacturing industries for this study. This study revealed a statistically significant difference in the hearing threshold within the selected industries over the selected period of time relating to the theory of excessive noise present in a given environment tends to affect people or in this case study employees hearing if proper hearing protection isn’t used for prolonged hours or time, the study also surveys the various effect of noise on human health including various steps of noise control in such settings.

关键词： Noise Noise Induced Hearing Loss NRR Auditory System Hearing Hearing Protective Devices acoustic trauma

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