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Ultrasound contrast agents from microbubbles to biogenic gas vesicles

Medical Review 2023年第1期3卷 31-48页

作者： Wenlong Zeng Xiuli Yue Zhifei Dai Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijingChina School of Environment Harbin Institute of TechnologyNo.92 Xidazhi StreetNangang DistrictHarbin 150001Heilongjiang ProvinceChina Department of Biomedical Engineering College of Future TechnologyPeking UniversityNo.5 Yiheyuan RoadHaidian DistrictBeijing 100871China

Microbubbles have been the earliest and most widely used ultrasound contrast agents by virtue of their unique features:such as non-toxicity,intravenous inject-ability,ability to cross the pulmonary capillary bed,and significant enhancement of echo signals for the duration of the examination,resulting in essential preclinical and clinical *** use of microbubbles functional-ized with targeting ligands to bind to speciﬁc targets in the bloodstream has further enabled ultrasound molecular ***,it is very challenging to utilize targeted microbubbles for molecular imaging of extra-vascular targets due to their size.A series of acoustic nanomaterials have been developed for breaking free from this ***,biogenic gas vesicles,gas-ﬁlled protein nanostructures from microorganisms,were engineered as theﬁrst biomolecular ultrasound contrast agents,opening the door for more direct visual-ization of cellular and molecular function by ultrasound *** ordered protein shell structure and unique gasﬁlling mechanism of biogenic gas vesicles endow them with excellent stability and attractive acoustic ***’s more,their genetic encodability enables them to act as acoustic reporter *** article reviews the upgrading progresses of ultrasound contrast agents from microbubbles to biogenic gas vesicles,and the opportu-nities and challenges for the commercial and clinical translation of the nascentﬁeld of biomolecular ultrasound.

关键词： acoustic nanomaterials acoustic reporter genes biogenic gas vesicles microbubbles ultrasound contrast agents ultrasound molecular imaging

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