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Protective effect of Amorphophallus campanulatus(Roxb.) *** against thioacetamide induced oxidative stress in rats

Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 870-877页

作者： Puthuparampil Nazarudeen Ansil Anand Nitha Santhibhavan Prabhakaran Prabha Pallara Janardhanan Wills Vahab Jazaira Mukalel Sankunni Latha Biochemistry and Pharmacognosy Research Laboratory School of BiosciencesM.G.UniversityP.O.Hills.P.O.KottayamKerala-686560India

Objective:To identify the phytochemical constituents of Amorphopkallus campanulatus(A. campanulatus) tuber and to evaluate its antioxidant potential through in vitro and in vivo models. Methods:Phytochemical screening and in vitro antioxidant activities of *** tuber n-hexane extract(ACHE) and methanolic extract(ACME) were evaluated using DPPH,hydroxyl radical,reducing power and total antioxidant capacity *** total phenolic and flavonoid contents were also *** protective potential of two different doses of ACME(125 and 250 mg/kg) was also evaluated against thioaeetamide(TAA) induced oxidative stress in rats. Silymarin used as a standard drug *** was assessed by quantifying the serum levels of aspartate aminotransferase(AST),alanine aminotransferase(AIT),alkaline phosphatase (ALP) and lactate dehydrogenase(LDH).The antioxidant potential of ACME were also evaluated by the estimation of catalase(CAT),glutathione peroxidase(GPx),glutathione reductase (OR),glutathione-S-transferase(GST),reduced glutathione(GSH) and lipid peroxidation (Thiobarbituric acid reactive substances) in hepatic and renal *** changes of liver were also ***:In vitro studies revealed that ACME has higher antioxidant and radical scavenging activity than ACHE,which may be attributed to its higher phenolic and flavonoid *** significandy prevented the elevation of serum AST,***,LDH,and tissue malondialdehyde levels(P < 0.05).Hepatic and renal ***,GPx,and catalase levels were remarkably increased by the treatment with the *** of histopathological changes also supported the dose dependent protective effects of ***:The results do suggest that *** tuber could be considered as a potential source of natural antioxidant.

关键词： Amorphophallus campanulatus Thioacetamide DPPH Hepatotoxicity Hepatoprotective Antioxidant aclivily Silymarin

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