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Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for accident proneness

Frontiers of Engineering Management 2016年第1期3卷 30-38页

作者： Shu-lin Zhang Hui-qing Jin Yang Song Wan-sheng Yu Liang-dan Sun Anhui Sanlian University National Center of Engineering and Technology for Vehicle Driving Safety Shanghai Zhuke Academy of Informationn Technology Institute of Dermatology and Department of Dermatology No.1 HospitalAnhui Medical University

Frequent traffic accidents constitute a major danger to human *** accident-prone driver who has the stable physiological,psychological,and behavioral characteristics is one of the most prominent causes of traffic *** internal link between the individual characteristics and the accident proneness has been a difficult point in the accident prevention *** authors selected accident-prone drivers as cases and safe drivers as controls(case-control group) from 18,360 drivers who were enrolled from three public transportation incorporations of China using area stratified sampling *** case-control groups were 1:1 *** authors performed genome-wide association study(GWAS) by 179 cases and 179 controls using the *** Genome-Wide Human Mapping SNP *** authors observed that the gene frequencies of34 single-nucleotide polymorphisms(SNPs) in three regions of cases were higher than those in the control(P accident proneness(Pcombined= 6.37×10^(-10)).According to CBLN4 gene mainly involved in adrenal development and the regulation of secretion,the authors performed 12 biochemical parameters of the blood using *** levels of dopamine(DA) and adrenocorticotropic(ACTH)hormone showed significant differences between accidentprone drivers and safe drivers(P_(DA)= 0.03,P_(ACTH)= 0.01).It is suggested that the accident-prone drivers may have the idiosyncrasy of susceptibility.

关键词： accident proneness genome-wide association study(GWAS) dopamine(DA) ACTH susceptibility gene traffic accident epidemiology accident prevention traffic safety three-dimensional model

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Research of Discriminating Driver accident proneness Based on Fuzzy Clustering

Research of Discriminating Driver Accident Proneness Based o...

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第13届中国系统仿真技术及其应用学术年会

作者： Zhiye YUAN,Renjun ZHAN Xi’an Engineering College of Armed Police Force,Xi’an,China,710086

For the facts that 70% of traffic accidents are accounted by the driver,and the most accidents are caused by part of the drivers with "accident proneness",this document proposes a new method about the evaluation of drivers’ psychological characteristics and skills characteristics,and establishes the drivers’ discriminate model by fuzzy clustering. Comparing with the equivalent number of accidents of the drivers,its credibility is high that the discriminate model is used to drivers’ accident proneness evaluation.

关键词： accident proneness discriminate model fuzzy Clustering evaluation

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A case-control study on family environment characteristics of accidentprone children

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Family Medicine and Community Health 2014年第4期2卷 26-31页

作者： Sisi Chen Leshan Zhou School of Nursing Central South UniversityChangshaHunan 410013P.R.China Central South University ChangshaHunan 410013P.R.China

Objective:The purpose of the current study was to determine the family environment charac-teristics of accident-prone children,and the influencing factors to provide a reference for accident prevention and intervention for these ***:One hundred forty-seven cases of accident-prone children were screened out from a cross-sectional survey as the case group,and another 147 cases of non-accidentally-injured chil-dren served as the control *** Chinese version of the Family Environment Scale(FES-CV)was applied to evaluate the family environment characteristics of subjects from both ***:The incidence of accident-prone children was 9.42%.Comparing the scores of all factors in the FES-CV,the contradiction score of the case group was higher than the control group,while the scores of other factors was lower than the control *** between the two groups with respect to intimacy,emotional expression,contradiction,independence,and success scores were statistically significant,but differences in informative and entertaining scores were *** with respect to family type,financial status,education,guardian,age of guardian,marital status,and health status were statistically *** revealed by regression analysis,intimacy(OR=0.530),emotional expression(OR=0.749),and independence(OR=0.732)were protective factors for accident proneness,while rigorous education(OR=2.101)and indulgence or indifference/violence(OR=7.629)were risk factors for accident ***:Family environment influence child accident proneness,thus preventive interventions should be provided according to the characteristics of the family environment.

关键词： Children accident proneness Family environment

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