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Experimental models of non-alcoholic fatty liver disease in rats

World Journal of Gastroenterology 2014年第26期20卷 8364-8376页

作者： Otto Kucera Zuzana Cervinkova Department of Physiology Charles University in PragueFaculty of Medicine in Hradec Kralove

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the Western world,and it persists at a high *** is characterised by the accumulation of triglycerides in the liver and includes a spectrum of histopathological findings,ranging from simple fatty liver through non-alcoholic steatohepatitis(NASH)to fibrosis and ultimately cirrhosis,which may progress to hepatocellular *** pathogenesis of NAFLD is closely related to the metabolic syndrome and insulin *** the pathophysiology and treatment of NAFLD in humans has currently been limited by the lack of satisfactory animal *** ideal animal model for NAFLD should reflect all aspects of the intricate etiopathogenesis of human NAFLD and the typical histological findings of its different *** the past several years,great emphasis has been placed on the development of an appropriate model for human *** paper reviews the widely used experimental models of NAFLD in *** discuss nutritional,genetic and combined models of NAFLD and their pros and *** choice of a suitable animal model for this disease while respecting its limitations may help to improve the understanding of its complex pathogenesis and to discover appropriate therapeutic *** the legislative,ethical,economical and health factors of NAFLD,animal models are essential tools for the research of this disease.

关键词： Animal model High-fat diet Methionine- and choline-deficient diet Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Otsuka-Long-Evans-Tokushima fatty rats zucker rats

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