检索结果-南通市图书馆

Danhong Huayu Koufuye combined with metformin attenuated diabetic retinopathy in zucker diabetic fatty rats

International Journal of Ophthalmology(English edition) 2015年第6期8卷 1094-1100页

作者： Wen-Pei Chen Yan-Dong Wang Yan Ma Zi-Yang Zhang Lu-Yun Hu Jun-Li Lin Bao-Qin Lin School of Chinese Materia Medica Guangzhou University of Chinese Medicine Zhongshan Ophthalmic Center Sun Yat-Sen University School of Chinese Materia Medica China Pharmaceutical University

AIM: To evaluate effects of Danhong Huayu Koufuye (DHK, a Chinese medicinal formulae) alone or combined with metformin on diabetic retinopathy (DR) in zucker diabetic fatty (ZDF) rats, an animal model of obese type -2 diabetes, and then to investigate the mechanisms. METHODS: ZDF (fa/fa) rats were administered with vehicle (distilled water), metformin, DHK, and DHK plus metformin. Electrophysiological and histological analysis were applied to evaluated effects of DHK alone or combined with metformin on DR. The levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in blood were measured to evaluate the antihyperglycemic activity of DHK. Furthermore, levels of nitric oxide (NO), malondialdehyde (MDA) and activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) in serum were measured to study effects of DHK on oxidative stress in ZDF rats. In addition, body weight, lipidic indexes and insulin level were also assessed. RESULTS: DHK combined with metformin significantly reversed the prolongation of latency times of flash electroretinogram (FERG) and oscillatory potentials (OPs) in diabetic rats. Furthermore, DHK alone or combined with metformin showed a remarkable suppression of retinal neovascularization and amelioration of retinal internal limiting membrane morphology. Moreover, DHK alone or plus metformin reduced FBG (Pdiabetic rats. In addition, reductions in levels of triglycerides (TG) (Pdiabetic rats treated with DHK alone or plus metformin. CONCLUSION: DHK in combination with metformin had a preventive and therapeutic effect on DR in type-2 diabetic rats, and the possible mechanisms may be alleviating hyperglycemia, reducing oxidative stress and improving lipid metabolism.

关键词： diabetic retinopathy Danhong HuayuKoufuye metformin zucker diabetic fatty rat antihyperglycemic activity oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes

引用

Neural Regeneration Research 2013年第26期8卷 2458-2467页

作者： Sung Min Nam Yo Na Kim Dae Young Yoo Sun Shin Yi Jung Hoon Choi In Koo Hwang Je Kyung Seong Yeo Sung Yoon Department of Anatomy and Cell Biology College of Veterinary Medicine Research Institute for Veterinary Science Seoul National University Department of Biomedical Laboratory Science College of Biomedical Sciences Soonchunhyang University Department of Anatomy College of Veterinary Medicine Kangwon National University

In the present study, we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of zucker diabetic fatty rats and zucker lean control rats. To induce hypothyroidism, zucker lean control and zucker diabetic fatty rats at 7 weeks of age orally received the vehicle or methimazole, an anti-thyroid drug, treatment for 5 weeks and were sacrificed at 12 weeks of age in all groups for blood chemistry and immunohistochemical staining. In the me- thimazole-treated zucker lean control and zucker diabetic fatty rats, the serum circulating triiodo- thyronine （T3） and thyroxine （＇I＂4） levels were significantly decreased compared to levels observed in the vehicle-treated zucker lean control or zucker diabetic fatty rats. This reduction was more prominent in the methimazole-treated zucker diabetic fatty group. Glial fibrillary acidic protein im- munoreactive astrocytes and ionized calcium-binding adapter molecule 1 （Iba-1）-immunoreactive microglia in the zucker lean control and zucker diabetic fatty group were diffusely detected in the hippocampal CA1 region and dentate gyrus. There were no significant differences in the glial fibril- lary acidic protein and Iba-1 immunoreactivity in the CA1 region and dentate gyrus between zucker lean control and zucker diabetic fatty groups. However, in the methimazole-treated zucker lean control and zucker diabetic fatty groups, the processes of glial fibrillary acidic protein immunoreac- tive astrocytes and Iba-1 immunoreactive microglia, were significantly decreased in both the CA1 region and dentate gyrus compared to that in the vehicle-treated zucker lean control and zucker diabetic fatty groups. These results suggest that diabetes has no effect on the morphology of as- trocytes and microglia and that hypothyroidism during the onset of diabetes prominently reduces the processes of astrocytes and microglia.

关键词： neural regeneration astrocytes microglia diabetes hypothyroidism complications thyroid hormone obesity methimazole zucker diabetic fatty rat grants-supported paper neuroregeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of transcutaneous auricular vagus nerve stimulation on fasting blood glucose and serum insulin concentration in zucker diabetes fatty rats

引用

World Journal of Acupuncture-Moxibustion 2021年第3期31卷 212-217页

作者： Zi-xuan ZHANG Shao-yuan LI Yu WANG Yue ZHANG Yi-fei WANG Pei-jing RONG Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Objective:To observe the influence of transcutaneous auricular vagus nerve stimulation(taVNS) on fasting plasma glucose(FPG) and serum insulin(INS) in zucker diabetes fatty(ZDF) rats and explore the regulatory effect of taVNS on blood glucose in ZDF ***:A total of 20 male ZDF rats were randomized into a model group and a taVNS group,10 rats in each ***,the other 10 zucker Lean(ZL) rats were selected to be a control *** rats in the control group were fed with common forage and those in the model group and the taVNS group were fed with high-sugar and high-fat *** intervention of electric stimulation was applied in the rats of taVNS group,with 2/15 Hz in frequency,disperse-dense wave and 2 mA in *** intervention lasted 30 min,once a day,consecutively for 12 *** any intervention was given in the control group and the model *** body mass and FPG level were recorded once every 2 weeks in the *** the experiment,the rats were sacrificed and blood sample was *** linked immunosorbent assay(ELISA) was adopted to determine the level of serum INS in the ***:After the modeling,compared with the control group,the body mass and FPG level were all higher(P ration of serum INS was lower(P rats of the model *** intervention,compared with the model group,the body mass was lower in week 6 to 10(P ration was higher(P rats of the taVNS ***:TaVNS apparently improves in hyperglycemia in ZDF rats and increases serum insulin concentration in the rats.

关键词： Transcutaneous auricular vagus nerve stimulation Type 2 diabetes mellitus zucker diabetic fatty rat Insulin Hypoglycemic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：