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A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound

Bioactive Materials 2023年第2期20卷 610-626页

作者： Zhengwei Liu Wanze Tang Jiayi Liu Yingying Han Qinnan Yan Yuechao Dong Xiaomei Liu Dazhi Yang Guixing Ma Huiling Cao Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen518055China Southern University of Science and Technology Shenzhen518055China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen518055China The First Affiliated Hospital Southern University of Science and TechnologyShenzhen518055China

A novel sprayable adhesive is established(znmet-pf127)by the combination of a thermosensitive hydrogel(Pluronic F127,pf127)and a coordination complex of zinc and metformin(znmet).Here we demonstrate that znmet-pf127 potently promotes the healing of traumatic skin defect and burn skin injury by promoting cell proliferation,angiogenesis,collagen ***,we find that znmet could inhibit reactive oxygen species(ROS)production through activation of autophagy,thereby protecting cell from oxidative stress induced damage and promoting healing of skin *** complex exerts better effects on promoting skin wound healing than ZnCl2 or metformin *** complex also displays excellent antibacterial activity against Staphylococcus aureus or Escherichia coli,which could reduce the incidence of skin wound ***,we demonstrate that sprayable pf127 could be used as a new drug delivery system for treatment of skin *** advantages of this sprayable system are obvious:(1)It is convenient to use;(2)The hydrogel can cover irregular skin defect sites evenly in a liquid *** combination with this system,we establish a novel sprayable adhesive(znmet-pf127)and demonstrate that it is a potential clinical treatment for traumatic skin defect and burn skin injury.

关键词： Thermosensitive hydrogel Skin wound znmet-pf127 Reactive oxygen species(ROS) Autophagy

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