检索结果-南通市图书馆

Protein@PP-Zn nanocomplex assembled by coordination of zinc ions used for intracellular protein delivery

Science China Chemistry 2023年第8期66卷 2354-2362页

作者： Liyun Cui Sainan Liu Fan Wu Hua Chen Yuanfeng Li Linqi Shi Yong Liu Rujiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China Wenzhou Institute University of Chinese Academy of SciencesWenzhou Key Laboratory of Interdiscipline and Translational MedicineWenzhou325001China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China

In recent years,intracellular delivery of protein drugs has attracted great attention,and polymer-based systems have been extensively exploited to develop efficient and safe ***,efficient intracellular delivery of protein drugs remains a challenge because of the cell membrane barrier and endosome ***,we report a protein@PP-Zn nanocomplex,which consists of an imidazole-containing block polymer poly(ethylene glycol)-block-poly(β-amino ester)(PEG-b-PAE(Im),PP),zinc ions,and protein drugs,for efficient intracellular protein ***-b-PAE(Im)could conjugate proteins via the bridging effect of zinc ions which simultaneously coordinate with imidazole groups on polymer and electron donor groups,such as imidazole and primary amine groups,on protein to improve the loading stability of *** a slightly acidic environment near cancer cells,the protonation of PAE(Im)backbone increases the positive charge density of the nanocomplex and promotes *** under a more acidic environment in endosomes,further protonation of imidazole groups leads to the disintegration of the nanocomplex and the breakdown of endosomes because of the proton sponge ***,protein is released into the *** the assistance of the nanocomplex,proteins with different sizes and isoelectric points are effectively delivered into *** work provides a stable,efficient and universal strategy for intracellular protein delivery.

关键词： protein zinc ions intracellular delivery coordination polymer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interlayer environment engineered MXene: Pre-intercalated Zn^(2+)ions as intercalants renders the modulated Li storage

引用

Journal of Energy Chemistry 2022年第5期31卷 306-313页

作者： Yixuan Wang Miao Liu Zhihe Wang Qinhua Gu Bo Liu Cuimei Zhao Junkai Zhang Shichong Xu Ming Lu Haibo Li Bingsen Zhang Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education The Joint Laboratory of MXene MaterialsJilin Normal UniversityChangchun 130103JilinChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina Key Laboratory of Preparation and Application of Environmental Friendly Materials of the Ministry of Education Jilin Normal UniversityChangchun 130103JilinChina School of Materials Science and Engineering University of Science and Techonology of ChinaShenyang 110016LiaoningChina

The intercalation of foreign species into MXene, as an approach of tuning the interlayer environment, is employed to improve electrochemical ion storage behaviors. Herein, to understand the effect of confined ions by the MXene layers on the performance of electrochemical energy storage, Zn^(2+) ions were employed to intercalate into MXene via an electrochemical technique. Zn^(2+) ions induced a shrink of the adjacent MXene layers. Meaningfully, a higher capacity of lithium ion storage was obtained after Zn^(2+) preintercalation. In order to explore the roles of the intercalated Zn^(2+) ions, the structural evolution, and the electronic migration among Zn, Ti and the surface termination were investigated to trace the origination of the higher Li^(+) storage capacity. The pre-intercalated Zn^(2+) ions lost electrons, meanwhile Ti of MXene obtained electrons. Moreover, a low-F surface functional groups was achieved. Contrary to the first shrink, after 200 cycles, a larger interlayer distance was monitored, this can accelerate the ion transport and offer a larger expansile space for lithium storage. This may offer a guidance to understand the roles of the confined ion by two-dimensional(2D) layered materials.

关键词： Ti_(3)C_(2)T_(x)MXene zinc ions Interlayer intercalation Lithium storage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

zinc-based metal organic framework with antibacterial and anti-inflammatory properties for promoting wound healing

引用

Regenerative Biomaterials 2022年第1期9卷 163-174页

作者： Yuting Chen Jinhong Cai Dachang Liu Shuhan Liu Doudou Lei Li Zheng Qingjun Wei Ming Gao Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical UniversityNo.22 Shuangyong RoadQingxiu DistrictNanning 530021China Department of Orthopaedics Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical UniversityNo.6 Shuangyong RoadQingxiu DistrictNanning 530021China Guangxi Collaborative Innovation Center of Regenerative Medicine and Medical Bioresource Development and Application The First Affiliated Hospital of Guangxi Medical UniversityNo.22 Shuangyong RoadQingxiu DistrictNanning 530021China Guangxi Key Laboratory of Regenerative Medicine The First Affiliated Hospital of Guangxi Medical UniversityNo.22 Shuangyong RoadQingxiu DistrictNanning 530021China

The synergistic effect of antibacterial and anti-inflammatory is needed to overcome the problem of wound healing *** on the favorable antibacterial and anti-inflammatory effect of zinc ions(Zn^(2+))and the physicochemical properties of metal organic frameworks(MOFs),we prepared nanosized zinc-based MOF:Zn-BTC with the ability to slowly release Zn^(2+).In cellular levels,Zn-BTC possessed lower toxicity to fibroblasts and enhanced capacity of cell proliferation and *** also had good bactericidal effect on multiple drug-resistant bacteria by reducing 41.4%MRSA and 47.2%Escherichia *** addition,Zn-BTC also displayed the ability of lowering the expression of antioxidant genes:superoxide dismutase 1,superoxide dismutase 2 and interleukin 6,and enhancing the expression of wound healing genes:transforming growth factors-b and type I ***,it also demonstrated that Zn-BTC could effectively improve the skin wound healing of SD rats and had no toxicity on major *** favorable biocompatibility,antibacterial and anti-inflammatory properties of Zn-BTC gave a new insight of designing novel MOFs for promoting skin wound healing.

关键词： zinc ions metal organic framework antibacterial anti-inflammatory skin wound healing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complexation of Triptycene-Derived Macrotricyclic Host Containing Pyridine Groups with Paraquat Derivatives: A Switchable Process Controlled by Zn^(2+) ions

引用

Chinese Journal of Chemistry 2014年第8期32卷 721-726页

作者： Ying Han Jiabin Guo Chuanfeng Chen Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

A triptycene-derived macrotricyclic host containing two pyridine groups was synthesized,and it could form 1∶1 stable host-guest complexes with paraquat derivatives in both solution and solid ***,it was also found tha... 详细信息

关键词： triptycene macrotricyclic host paraquat switchable zinc ions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrochemical reduction mechanism of Zn^(2+)in molten NaCl-KCl eutectic

引用

Transactions of Nonferrous Metals Society of China 2022年第9期32卷 3088-3098页

作者： Xiao-bin WU Zeng-li ZHU Hui KONG You-qi FAN Si-wei CHENG Zhong-sheng HUA School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243032China Anhui Provincial Key Laboratory of Metallurgical Engineering&Resources Recycling Anhui University of TechnologyMa’anshan 243002China

A process comprising selective chlorination and molten salt electrolysis was proposed to develop an efficient and environmental-friendly technology for zinc recovery from metallurgical *** theoretical feasibility of this technology was firstly estimated based on thermodynamic ***,the electrochemical behavior of Zn^(2+)on tungsten electrode was investigated in molten NaCl-KCl eutectic at 973 K by many electrochemical transient *** results showed that the reduction of Zn^(2+)on tungsten electrode was found to be a one-step process exchanging two electrons with the initial reduction potential of-0.74 V(vs Ag/AgCl),and the electrode process was considered as quasi-reversible and controlled by *** diffusion coefficient of Zn^(2+)ions in the melts was determined in the order of 10^(-5)cm^(2)/***,the electrolytic preparation of zinc was carried out by potentiostatic electrolysis in molten NaCl-KCl-ZnCl_(2)eutectic at-1.6 V(vs Ag/AgCl).Spheroidic granular metal with silver-white luster was attained after electrolysis for 9.5 h,and identified as pure *** present study confirms that it is practically feasible to extract pure zinc metal by direct electrolysis of ZnCl_(2)in molten NaCl-KCl eutectic,and provides a valuable theoretical reference for the efficient recovery of zinc from metallurgical dusts.

关键词： electrochemical reduction zinc ions electrochemical behavior molten NaCl-KCl eutectic metallurgical dusts

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：