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Influence of zinc sulfate intake on acute ethanol-induced liver injury in rats

World Journal of Gastroenterology 2006年第27期12卷 4345-4351页

作者： Sema Bolkent Pelin Arda-Pirincci Sehnaz Bolkent Refiye Yanardag Sevim Tunali Sukriye Yildirim Department of Medical Biology Cerrahpasa Faculty of MedicineIstanbul UniversityCerrahpasa 34098IstanbulTurkey Department of Biology Faculty of ScienceIstanbul UniversityVezneciler 34459IstanbulTurkey Department of Chemistry Faculty of EngineeringIstanbul UniversityAvcilar 34850IstanbulTurkey

AIM： To investigate the role of metallothionein and proliferating cell nuclear antigen （PCNA） on the morphological and biochemical effects of zinc sulfate in ethanol-induced liver injury. METHODS： Wistar albino rats were divided into four groups. Group Ⅰ ; intact rats, group Ⅱ, control rats given only zinc, group ITl; animals given absolute ethanol, group Ⅳ; rats given zinc and absolute ethanol. Ethanol-induced injury was produced by the 1 mL of absolute ethanol, administrated by garage technique to each rat. Animals received 100 mg/kg per day zinc sulfate for 3 d 2 h prior to the administration of absolute ethanol. RESULTS： Increases in metallothionein immunoreactivity in control rats given only zinc and rats given zinc and ethanol were observed. PCNA immunohistochemistry showed that the number of PCNA-positive hepatocytes was increased significantly in the livers of rats administered ethanol ＋ zinc sulfate. Acute ethanol exposure caused degenerative morphological changes in the liver. Blood glutathione levels decreased, serum alkaline phosphatase and aspartate transaminase activities increased in the ethanol group when compared to the control group. Liver glutathione levels were reduced, but lipid peroxidation increased in the livers of the group administered ethanol as compared to the other groups. Administration of zinc sulfate in the ethanol group caused a significant decrease in degenerative changes, lipid peroxidation, and alkaline phosphatase and aspartate transaminase activities, but an increase in liver glutathione. CONCLUSION： zinc sulfate has a protective effect on ethanol-induced liver injury. In addition, cell proliferation may be related to the increase in metallothionein immunoreactivity in the livers of rats administered ethanol ＋ zinc sulfate.

关键词： Liver Ethanol zinc sulfate Metallothionein Proliferating cell nuclear antigen Rat

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Effect of zinc sulfate against the Red Palm Weevil Rhynchophorus ferrugineus with Reference to Their Histological Changes on the Larval Midgut and Adult Reproductive System

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Journal of Agricultural Science and Technology(A) 2012年第7期2卷 888-900页

作者： Zamzam M. Al-Dhafar Aziza Sharaby Department of Biology Dammam University Dammam 31481 Eastern Province Saudi Arabia Pests & Plant Protection Department National Research Center Cairo Egypt

The red palm weevil Rhynchophorusferrugineus is the most important insect pest for the date palm trees in the Middle East and Gulf states. zinc sulfate （ZnSOa＇H20） was toxicologically, biologically and physiologically evaluated as insect development disruptors against the RPW. LCs0 of zinc sulfate against 10 days old larvae was 0.566%, 3% concentration inhibited the larvae from feeding. LCs0 concentration of zinc sulfate solution was capable to disrupting growth, development and reproduction of R. ferrugineus. Growth and development disruptions are resulted from larval feeding on the treated diet that causing percentage of mortality rate, retardation in larval and pupal duration, percentage of pupation, adults emergence, reduction in deposited eggs that laid by the resulting adults and in the egg fertility. The study further reveals that zinc sulfate effects on histological structure of epithelial cells of the larval midgut including separation and elongation of their cells, rupture in the peritrophic membrane and in some microvilli and some degeneration of the surrounding muscles. Histological changes also was observed on the adults ovary, in this way, disrupt female gamete production through their action on the accumulation of yolk granules （vitellogenesis） and follicular epithelial cells. Disruption of male gamete production was detected by disorganized of testicular cysts and depopulation of these cysts in addition to degeneration in germ cells. zinc sulfate may be used among other control methods by injection into the tree trunk or as fertilizer around the tree roots which in turn may have an indirect effect for controlling the RPW.

关键词： Red palm weevil zinc sulfate inorganic salt toxicity growth disruption histological changes midgut ovary testes Rhynchophorus ferrugineus.

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Treatment of Acute Cutaneous Leishmaniasis by Oral zinc sulfate and Oral Ketocanazole Singly and in Combination

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Journal of Cosmetics, Dermatological Sciences and Applications 2016年第3期6卷 105-115页

作者： Khalifa E. Sharquie Adil A. Noaimi Wasnaa S. Al-Salam Department of Dermatology College of Medicine University of Baghdad Baghdad Iraq Iraq and Arab Board for Dermatology & Venereology Baghdad Teaching Hospital Medical City Baghdad Iraq Department of Dermatology Baghdad Teaching Hospital Medical City Baghdad Iraq

Background: Cutaneous Leishmaniasis (CL) is an endemic disease in many countries and caused by different species of Leishmania parasite. It results in a deformed scar after a relatively long period. Many therapies have been tried in treatment of this disease. Objective: To compare the effect of oral zinc sulfate and oral ketoconazole singly and in combination in the treatment of acute cutaneous leishmaniasis. Patients and Methods: This single, blinded, therapeutic, controlled study was conducted in the Department of Dermatology, Baghdad Teaching Hospital, Baghdad, Iraq, during the period, January 2015 to July 2015. Seventy-five patients with acute CL were enrolled in this study. The total numbers of lesions were 327, and the duration of lesions ranged from 4 to 12 (6.9 ± 0.7) weeks. The diagnosis was confirmed by smear and histopathology. Patients were divided into three groups: 24 patients in Group A were treated with oral zinc sulfate capsules 10 mg/kg/day for 6 weeks;24 patients in Group B were treated with ketoconazole tablets 200 mg twice daily for 6 weeks and 27 patients in Group C were treated orally with a combination of zinc sulfate and ketoconazole for 6 weeks. All patients were seen regularly every 2 weeks for 6 weeks of treatment period, then monthly for the next three months as follow up period. Healing of the lesions was assessed by using Sharquie’s modified Leishmania score to assess the objective response to the topical or systemic therapy. Results:After six weeks, 75 patients have completed the treatment, 24patients received zinc sulfate capsule, 24 patients received oral ketoconazole and 27 patients received a combination of both treatments. The cure rate was (60%) in the group receiving oral zinc sulfate capsuleand (50%) in the one receiving oral ketoconazole tablet (P = 0.146) and (96%) in the combination group (P ? 0.04). Conclusion: The combination therapy using oral zinc sulfate and oral ketoconazole gave a high cure rate. The combination ther

关键词： Cutaneous Leishmaniasis Ketoconazole zinc sulfate Sharquie’s Modified Leishmania Score

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Studies on the Hydrogen Bonding Network Structures of Amino-konjacglucomannan-zinc Chelate

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Chinese Journal of Structural Chemistry 2014年第2期33卷 171-178页

作者：王丽霞姜雯林超平钟巧霞庞杰 College of Food Science Fujian Agriculture and Forestry University Department of Biology Science and Technology Minnan Normal University College of Food Science and Engineering Yangzhou University

Amino-Konjacglucomannan （NH2-KGM） was prepared through the reaction of ammonium hydroxide with KGM by ultrasonic. The influence of amount of ammonium hydroxide, concentration of KGM and ultrasonic time on the extent of amination was studied. Then, NH2-KGM and zinc sulfate were used as materials for the preparation of NH2-KGM-Zn complex. The results indicated that the extent of amination increases with increasing the ammonium hydroxide. The optimum concentration of KGM and ultrasonic time are 0.3% and 75 rain respectively. IR showed KGM is successfully aminated and NH2-KGM forms stable complex with zinc（II ）. The hydrogen bonding network structures of NH2-KGM-Zn are more stable and the key linking points of hydrogen bonding network are at the OH（6） and 0（3） positions of mannose and OH（2） of glucose and 0（3） of mannose on the KGM ring. It is more favorable for NH2-KGM-Zn to form intermolecular hydrogen bonds between KGM.

关键词： Konjac glucomannan (KGM) aminated ultrasonic zinc sulfate chelate

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Structural and morphological characterizations of ZnO nanopowder synthesized by hydrothermal route using inorganic reactants

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Journal of Semiconductors 2014年第12期35卷 8-12页

作者： D.Djouadi M.Meddouri A.Chelouche L.Hammiche A.Aksas Laboratoire de Génie de l'Environnement(LGE) Université de Béjaia Algérie

zinc oxide nanoscale powder has been synthesized by a hydrothermal route using zinc sulfate and sodium hydroxide. The as-prepared powder was annealed at 600 ℃ for 2 h and then characterized by X-ray diffraction（XRD）, scanning electron microscopy and infra-red Fourier transformed spectroscopy. XRD measurements have shown a Zn O hexagonal wurtzite polycrystalline structure with good crystallinity and the formation of a new sodium pyrosulfate phase in the as-prepared powder. The annealing improves the crystalline quality of the powder and transforms the sodium pyrosulfate phase to a sodium sulfate one. The thermal treatment does not affect the lattice parameters and the Zn–O bond length but improves the random orientation of the Zn O crystallites *** O crystallites have an interconnected-nano-needles morphology forming irregular shaped aggregates. The size of the crystallites is about 20 nm. EDX analysis has shown the presence of C and S in addition to Zn and O. FTIR spectra confirm the formation of Zn O and sodium sulfate. The synthesized Zn O powder has a very high crystalline quality and the used method is a very advantageous one for the fabrication of nanosized metal oxides from inorganic reactants for photo-catalysis applications.

关键词： Zn O hydrothermal method zinc sulfate nanoneedles DRX SEM FTIR

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Effects of two transition metal sulfate salts on secondary organic aerosol formation in toluene/NOx photooxidation

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Frontiers of Environmental Science & Engineering 2013年第1期7卷 1-9页

作者： Biwu CHU Jiming HAO Junhua LI Hideto TAKEKAWA Kun WANG Jingkun JIANG State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Beijing 100084 China Toyota Central Research and Development Laboratory Nagakute Aichi 480-1192 Japan

Aerosol phase reactions play a very important role on secondary organic aerosol (SOA) formation, and metal-containing aerosols are important components in the atmosphere. In this study, we tested the effects of two transition metal sulfate salts, manganese sulfate (MnSO4) and zinc sulfate (ZnSO4), on the photochemical reactions of a toluene/NO x photooxidation system in a 2 m3 smog chamber. By comparing photochemical reaction products of experiments with and without transition metal sulfate seed aerosols, we evaluated the effects of transition metal sulfate seed aerosols on toluene consumption, NO x conversion and the formation of ozone and SOA. MnSO4 and ZnSO4 seed aerosols were found to have similar effects on photochemical reactions, both enhance the SOA production, while showing negligible effects on the gas phase compounds. These observations are consistent when varying metal sulfate aerosol concentrations. This is attributed to the catalytic effects of MnSO4 and ZnSO4 seed aerosols which may enhance the formation of condensable semivolatile compounds. Their subsequent partitioning into the aerosol phase leads to the observed SOA formation enhancement.

关键词： manganese sulfate zinc sulfate seed aerosols toluene photooxidation secondary organic aeroso

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Investigation of the Crystallization Kinetics of Zn(Leu)SO _4·0.5H_2O in Mixing Solvent by Microcalorimetry

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Chinese Journal of Chemistry 2003年第4期21卷 400-404页

作者：陈三平房艳高胜利胡荣祖史启祯 Shaanxi Key Laboratory of Physico Inorganic Chemistry&Department of Chemistry Northwest University

The crystal growth process of Zn(Leu)SO 4·0 5H 2O from water and acetone was investigated using a Calvet microcalorimeter. The heat and the rate of heat production during the crystal growth process at 293 15 K, 295 15 K, 298 15 K and 300 15 K were measured. On the basis of experimental and calculated results, the rate constant and the kinetic parameters (the activation energies, the pre exponential) during the crystal growth process were obtained. The results show that the crystal growth process accorded with the Burton Cabrera Frank dislocation theory.

关键词： zinc sulfate L α leucine complex crystallization kinetics microcalorimetry

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Heat shock protein 72 confers protection in retinal ganglion cells and lateral geniculate nucleus neurons via blockade of the SAPK/JNK pathway in a chronic ocular-hypertensive rat model

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Neural Regeneration Research 2014年第14期9卷 1395-1401页

作者： Ning Li Yuehua Li Xuanchu Duan Department of Ophthalmology The First Affiliated Hospital of Anhui Medical University Department of Ophthalmology Second Xiangya HospitalCentral South University

Optic nerve transection increased the expression of heat shock protein 72 （HSP72） in the lateral geniculate body, indicating that this protein is involved in the prevention of neuronal injury. zinc sulfate and quercetin induced and inhibited the expression of HSP72, respectively. Intraperitoneal injections of zinc sulfate, SP600125 （c-Jun N-terminal kinase inhibitor）, or quercetin were performed on retinal ganglion cells in a Wistar rat model of chronic ocular hypertension. Our results showed that compared with the control group, the expression of HSP72 in retinal ganglion cells and the lateral geniculate body was increased after the injection of zinc sulfate, but was decreased after the injection of quercetin. The expression of phosphorylated c-Jun N-terminal kinases and phosphorylated c-Jun were visible 3 days after injection in the control group, and reached apeak at 7 days. zinc sulfate and SP600125 significantly decreased the expression of p-c-Jun, whereas quercetin significantly enhanced the expression of this protein. These results suggest that HSP72 protects retinal ganglion cells and lateral geniculate body in a rat model of chronic ocular hypertension from injury by blocking the activation of the stress-activated kinase/c-Jun N-terminal kinase apoptotic pathway.

关键词： nerve regeneration peripheral nerve injury glaucoma heat shock protein 72 retinalganglion cells lateral geniculate body zinc sulfate quercetin SAPK/JNK pathway neuroprotection p-INK p-c-Jun NSFC grant neural regeneration

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