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Introduction of zika virus in Bangladesh:An impending public health threat

Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 925-928页

作者： A.K.M.Muraduzzaman Sharmin Sultana Tahmina Shirin Selina Khatun MdTarikul Islam Mahmudur Rahman Department of Virology Institute of EpidemiologyDisease Control&Research(IEDCR)DhakaBangladesh Department of Epidemiology Institute of EpidemiologyDisease Control&Research(IEDCR)DhakaBangladesh Laboratory of Genetics and Genomics Institute for Developing Science and Health InitiativesDhakaBangladesh Institute of Epidemiology Disease Control&Research(IEDCR)DhakaBangladesh

Objective: To explore the presence of zika virus(ZIKV) in Bangladesh and to understand the associated risk factors.Methods: A retrospective sero-surveillance was performed on stored serum samples of dengue surveillance conducted from 2013 to 2016. Real time RT-PCR was performed on randomly selected acute serum samples to detect the zika virus nucleic acid.Results: Of 200 samples screened, one was found positive for ZIKV by real time RTPCR and further confirmed by genome sequencing. The case was a 65 years old male from a metropolitan city of Bangladesh who had no history of travel outside Bangladesh.Phylogenetic analysis of partial E gene sequences from Bangladeshi isolates demonstrated a close relationship with ZIKV from Brazil and current South American strains clustering within a monophyletic clade distinct from African lineage.Conclusions: Presence of ZIKV raises serious public health concerns in Bangladesh owing to its association with congenital anomalies/neurological-manifestations. We,therefore, recommend every suspected viral fever patient, particularly pregnant women be screened for ZIKV infection to rule out yet another emerging infection in Bangladesh.

关键词： zika 病毒孟加拉国公共健康影响

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Doubled dosage of sofosbuviris expected for inhibiting zika virus infection

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Asian Pacific Journal of Tropical Medicine 2017年第6期10卷 682-683页

作者： Somsri Wiwanitkit Viroj Wiwanitkit Wiwanitkit House BangkhaeBangkok Thailand Hainan Medical University China Dr DY Patil University India Faculty of Medicine University of NisSerbia Joseph Ayobabalola University Nigeria

Sofosbuvir is a new antiviral drug that has been recommended for management of hepatitis C virus(HCV) for a few years. New researches support that sofosbuvir might be useful for the management of zika virus infection. Based on the pharmacological activity, inhibiting the HCV RNA-dependent RNA polymerase(RdR p or NS5 protein), sofosbuvir is proposed for its effectiveness against zika virus infection. Here, the authors used a mathematical modelling theoretical approach to predict the expected dosage of sofosbuvir for inhibiting zika virus infection. Based on the modeling study, if sofosbuvir is assigned for management of zika virus infection, doubled dosage of the present dosage for hepatitis C management is recommended.

关键词： Sofosbuvir 禁止 zika 病毒剂量

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Cleft analysis of zika virus non-structural protein 1

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 763-764页

作者： Somsri Wiwanitkit Viroj Wiwanitkit Wiwanitkit House Hainan Medical University

The non-strctural protein 1 is an important molecule of the viruses in flavivirus group including to zika virus. Recently, the NS1 of zika virus was discovered.There is still no complete information of the molecular interaction of NS1 of zika virus which can be the clue for explanation for its pathogenesis and further drug search. Here the authors report the cleft analysis of NS1 of zika virus and the result can be useful for future development of good diagnostic tool and antiviral drug finding for management of zika virus.

关键词： zika 病毒非结构的蛋白质 1 劈开 Flavivirus

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