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An FPS-ZM1-encapsulated zeolitic imidazolate framework as a dual proangiogenic drug delivery system for diabetic wound healing

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Nano Research 2022年第6期15卷 5216-5229页

作者： Yi Sun Bingbo Bao Yu Zhu Junjie Shen Xuanzhe Liu Tao Gao Junqing Lin Tengli Huang Jia Xu Yimin Chai Xianyou Zheng Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Institute of Microsurgery on Extremities Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Inhibitors that target diabetes pathology-related signaling pathways have great therapeutic potential for diabetic wound healing.Metal–organic frameworks(MOFs)are increasingly popular drug delivery systems that have high loading capacity and can release their intrinsic metal ions to act as bioactive agents.In light of this,a receptor for advanced glycation end products(RAGE)inhibitor,4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide(FPS-ZM1),was loaded into a cobalt(Co)-based MOF(zeolitic imidazolate framework-67,ZIF-67)to fabricate FPS-ZM1 encapsulated ZIF-67(FZ@ZIF-67)nanoparticles(NPs).As a result,FZ@ZIF-67 NPs could dually deliver Co ions and FPS-ZM1 in a controlled manner for over 14 days.Our in vitro study showed that FZ@ZIF-67 NPs not only enhanced angiogenesis by delivering Co ions but also released FPS-ZM1 to promote M2 macrophage polarization and attenuated high glucose(HG)-and/or inflammation-induced impairment of angiogenesis through RAGE inhibition.Moreover,in an in vivo study,FZ@ZIF-67 NPs markedly improved re-epithelialization,collagen deposition,neovascularization,and relieved inflammation in diabetic wounds in rats.This study not only provides a low-cost,effective,and synergistic proangiogenic bioactive agent but also demonstrates that targeting diabetes-related pathological signaling pathways is necessary to ameliorate vascularization impairment during diabetic wound healing.

关键词： zeolitic imidazolate framework-67 drug delivery dual-controlled release angiogenesis diabetic wound

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Recent progress on synthesis of ZIF-67-based materials and their application to heterogeneous catalysis

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Green Energy & Environment 2022年第1期7卷 3-15页

作者： Chongxiong Duan Yi Yu Han Hu State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringInstitute of New EnergyChina University of Petroleum(East China)Qingdao266580China School of Materials Science and Hydrogen Engineering Foshan UniversityFoshan528231China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510640China

In recent years,an increasing amount of interest has been dedicated to the synthesis and application of ZIF-67-based materials due to their exceptionally high surface area,tunable porosity,and excellent thermal and chemical stabilities.This review summarizes the latest strategies of synthesizing ZIF-67-based materials by exploring the prominent examples.Then,the recent progress in the applications of ZIF-67-based materials in heterogeneous catalysis,including catalysis of the redox reactions,addition reactions,esterification reactions,Knoevenagel condensations,and hydrogenation-dehydrogenation reactions,has been elaborately discussed.Finally,we end this work by shedding some light on the large-scale industrial production of ZIF-67-based materials and their applications in the future.

关键词： zeolitic imidazolate framework-67 Synthetic methods Heterogeneous catalysis

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Defects enriched hollow porous Co-N-doped carbons embedded with ultrafine CoFe/Co nanoparticles as bifunctional oxygen electrocatalyst for rechargeable flexible solid zinc-air batteries

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Nano Research 2021年第3期14卷 868-878页

作者： Zhao Lei Yangyang Tan Zeyi Zhang Wei Wu Niancai Cheng Runzhe Chen Shichun Mu Xueliang Sun College of Materials Science and Engineering Fuzhou UniversityFuzhou350108China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Department of Mechanical and Materials Engineering The University of Western OntarioLondonONN6A 5B9Canada

The construction and design of highly efficient and inexpensive bifunctional oxygen electrocatalysts substitute for noble-metal-based catalysts is highly desirable for the development of rechargeable Zn-air battery(ZAB).In this work,a bifunctional oxygen electrocatalysts of based on ultrafine CoFe alloy(4-5 nm)dispersed in defects enriched hollow porous Co-N-doped carbons,made by annealing SiO2 coated zeolitic imidazolate framework-67(ZIF-67)encapsulated Fe ions.The hollow porous structure not only exposed the active sites inside ZIF-67,but also provided efficient charge and mass transfer.The strong synergetic coupling among high-density CoFe alloys and Co-N_(x) sites in Co,N-doped carbon species ensures high oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)activity.First-principles simulations reveal that the synergistic promotion effect between CoFe alloy and Co-N site effectively reduced the formation energy of from O^(*)to OH^(*).The optimized CoFe-Co@PNC exhibits outstanding electrocatalytic stability and activity with the overpotential of only 320 mV for OER at 10 mA·cm^(−2) and the half-wave potential of 0.887 V for ORR,outperforming that of most recent reported bifunctional electrocatalysts.A rechargeable ZAB constructed with CoFe-Co@PNC as the air cathode displays long-term cyclability for over 200 h and high power density(152.8 mW·cm^(−2)).Flexible solid-state ZAB with our CoFe-Co@PNC as the air cathode possesses a high open circuit potential(OCP)up to 1.46 V as well as good bending flexibility.This universal structure design provides an attractive and instructive model for the application of nanomaterials derived from MOF in the field of sustainable flexible energy applications device.

关键词： oxygen reduction reaction ultrafine CoFe alloy hollow porous carbons zeolitic imidazolate framework-67 Zn-air battery

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