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In vitro-in vivo studies on anti-trypanosomal potentials of zapoteca portoricensis

Asian Pacific Journal of Tropical Medicine 2009年第1期2卷 25-29页

作者： Nwodo NJ Omeje EO Bran R Department of Pharmaceutical Chemistry University of NigeriaNsukkaNigeria Department of Medical Parasitology and Infection Biology Swiss Tropical InstituteCH-4002 BaselSwitzerland

Objective:Aqueous extracts of zapoteca portoricensis are used traditionally as antidiarrhea agent and in the treatment of diverse gastrointestinal disorders here in Nigeria specifically,the southern ***,the aqueous extract of the plant is also used traditionally as anticonvulsant,antispasmodic and in the treatment of *** too,the anti-inflammatory and antimicrobial activities of the methanol extracts of the root of zapoteca portoricensis was *** this research,we are set to investigate the trypanocidal activity of zapoteca ***:The methanol extract of the root of zapoteca portoricensis was investigated for both in vitro and in vivo trypanocidal activity following established *** summary,phytochemical analysis was carried out on both the crude powdered root and on the methanol extract following standard procedures. The oral acute toxicity test(LD50 ) of the crude methanol extract was determined according to the method described by Lorke（1983）.Albino mice（17g-21g） of either sex were *** methanol extract was suspended in 3%v/v tween 85 and administered orally at doses of 10 mg/kg,100 mg/kg and 1 000 mg/kg to three groups of mice（n = 3 ）.The animals were observed for 24 *** on the result obtained in this initial test,doses of 4 mg/kg,6 mg/kg,and 8 mg/kg were administered to three different *** LD50 was calculated as the geometric mean of the lowest dose killing a mouse and the highest dose showing no *** invivo /in-vitro antitrypanosomal evaluations were carried out in experimental animals and tissue cell culture respectively. Results:The result of the in vitro studies shows the inhibitive concentration-50（IC-50） against Trypanosoma brucei rhodesiense（***） to be 0.372 mg/kg,while the control drug melarsoprol was 0.006 mg/*** Trypanosoma brucei brucei（***）,the IC-50 is 6.42 mg/kg against 0.87 of the reference drug *** cytotoxicity on L-6 c

关键词： zapoteca portoricensis Trypanocidal effects T.b.rhodensiense T.cruzi In vitro/in vivo model

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Phytochemical screening, hepatoprotective and antioxidant effects of leaf extracts of <i>zapoteca portoricensis</i>

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Advances in Biological Chemistry 2014年第1期4卷 35-39页

作者： Kingsley Nwonu Agbafor Moses Eje Ogbanshi Emmanuel Iroha Akubugwo Biochemistry Department Abia State University Uturu Nigeria Biochemistry Department Ebonyi State University Abakaliki Nigeria

Fresh leaves of zapoteca portoricensis are used in Eastern Nigeria for management/treatment of various disorders without any scientific basis. Hepatoprotective and antioxidant properties in albino rats, and phytochemical composition of distilled water and ethanol leaf extracts were studied. Fifty-five animals were placed in eleven groups (A-K) of five in each. Different doses (100, 200, 400 and 600 mg/kg body weight) of the extracts, 20 mg/kg body weight of vitamin C (standard antioxidant) and distilled water were orally administered to groups A-H, I and J-K respectively for six consecutive days. On the seventh day, 2.5 ml/kg body weight of carbon tetrachloride (CCl4) was given intraperitoneally to groups A-J, while group K received distilled. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyltransferase (GGT) were used to study hepatoprotective effect. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels in the liver were monitored to assess antioxidant activity. Phytochemical analysis revealed the presence of alkaloids, tannins, saponins, flavonoids, anthraquinones, terpenoids and cardiac glycosides in the extracts. Pretreatment of the rats with the extracts produced a significant decrease (p < 0.05) in ALT, AST, GGT and MDA, while the activity of SOD and CAT increased significantly (p < 0.05) relative to the positive control. These results, which were dose-dependent, are indicative of hepatoprotective and antioxidants potentials of the extracts, and may be due to their phytoconstituents.

关键词： Albino Rats Carbon Tetrachloride zapoteca portoricensis Phytochemicals Liver Enzymes Antioxidant Activity

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