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Long noncoding RNA znfx1-as1 promotes the invasion and proliferation of gastric cancer cells by regulating LIN28 and CAPR1N1

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World Journal of Gastroenterology 2022年第34期28卷 4973-4992页

作者： Zhong-Ling Zhuo Hai-Peng Xian Yu-Jing Sun Yan Long Chang Liu Bin Liang Xiao-Tao Zhao Department of Clinical Laboratory Peking University People’s HospitalBeijing 100044China The Key Laboratory of Geriatrics Peking University Fifth School of Clinical MedicineBeijing 100730China Department of Clinical Laboratory Peking University International HospitalBeijing 100044China Department of Gastrointestinal Surgery Peking University People’s HospitalBeijing 100044China

BACKGROUND Long noncoding RNA(lncRNA)znfx1-as1(ZFas1)is a newly discovered lncRNA,but its diagnostic value in gastric cancer is unclear.AIM To investigate the potential role of ZFas1 in gastric cancer and to evaluate the clinical significance of ZFas1 as a biomarker for gastric cancer screening.METHODS Quantitative real-time polymerase chain reaction(qRT-PCR)was used to screen for gastric cancer-associated lncRNAs in gastric cancer patients,gastric stromal tumor patients,gastritis or gastric ulcer patients,and healthy controls.Correlations between ZFas1 expression and clinicopathological features were analyzed.The biological effects of ZFas1 on the proliferation,migration,and invasion of gastric cancer cells were studied by MTT,colony formation,and transwell migration assays.The potential mechanism of ZFas1 was demonstrated using enzyme-linked immunosorbent assay and qRT-PCR.The relationship between ZFas1 and tumorigenesis was demonstrated using in vivo tumor formation assays.RESULTS The plasma level of lncRNA ZFas1 was significantly higher in preoperative patients with gastric cancer than in individuals in the other 4 groups.Increased expression of ZFas1 was significantly associated with lymph node metastasis,advanced TNM stage,and poor prognosis.ZFas1 regulated the proliferation,migration,and invasion of gastric cancer cells and regulated the growth of gastric cancer cells in vivo.LIN28 and CAPRIN1 were identified as key downstream mediators of ZFas1 in gastric cancer cells.CONCLUSION LncRNA ZFas1 promoted the invasion and proliferation of gastric cancer cells by modulating LIN28 and CAPRIN1 expression,suggesting that ZFas1 can be used as a potential diagnostic and prognostic biomarker in gastric cancer.

关键词： Long noncoding RNA znfx1-as1 Gastric cancer Biomarker Invasion Proliferation

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