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zataria multiflora and its constituent,carvacrol,counteract sepsis-induced aortic and cardiac toxicity in rat:Involvement of nitric oxide and oxidative stress

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Animal Models and Experimental Medicine 2023年第3期6卷 221-229页

作者： Mahmoud Hosseini zohreh Arab Farimah Beheshti Akbar Anaeigoudari Farzaneh Shakeri Arezoo Rajabian Psychiatry and Behavioral Sciences Research Center Mashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran Neuroscience Research Center Torbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Department of Physiology School of Paramedical SciencesTorbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Department of Physiology School of MedicineJiroft University of Medical SciencesJiroftIran Natural Products and Medicinal Plants Research Center North Khorasan University of Medical SciencesBojnurdIran Department of Physiology and Pharmacology School of MedicineNorth Khorasan University of Medical SciencesBojnurdIran Department of Internal Medicine Faculty of MedicineMashhad University of Medical SciencesMashhadIran

Background:zataria multiflora and carvacrol showed various pharmacological prop-erties including anti-inflammatory and anti-oxidant ***,up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac ***,this study aimed to investigate the effects of *** and carvacrol on nitric oxide(NO)and oxidative stress indicators in lipopolysaccharide(LPS)-induced aortic and cardiac ***:Adult male Wistar rats were assigned to:Control,lipopolysaccharide(LPS)(1 mg/kg,intraperitoneal(i.p.)),and *** hydro-ethanolic extract(zME,50–200 mg/kg,oral)-and carvacrol(25–100 mg/kg,oral)-treated *** was in-jected daily for 14 *** with zME and carvacrol started 3 days before LPS administration and treatment continued during LPS *** the end of the study,the levels of malondialdehyde(MDA),NO,thiols,and antioxidant enzymes were ***:Our findings showed a significant reduction in the levels of superoxide dis-mutase(SOD),catalase(CAT),and thiols in the LPS group,which were restored by zME and ***,zME and carvacrol decreased MDA and NO in car-diac and aortic tissues of LPS-injected ***:The results suggest protective effects of zME and carvacrol on LPS-induced cardiovascular injury via improved redox hemostasis and attenuated NO ***,additional studies are needed to elucidate the effects of zME and its constituents on inflammatory responses mediated by LPS.

关键词： carvacrol lipopolysaccharide nitric oxide oxidative injury sepsis z.multiflora

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