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第三届世界中西医结合大会

作者： Shi Dazhuo~1 Ma Lubo~1 Liu Jiangang~1 Meng Liang~2 Zhou Yanwen~2 Yuan Weimin~2 1.Xiyuan Hospital of China Academy of TCM 2.Fuwai Cardiovascular Disease Hospital of Chinese Academy of Medical Sciences

＜正＞Objective:To explore the acting mechanism of yuxingeng Fliud（YXGF,a Chinese herb compound prescription）in intervening ventricular remodeling（VR）after acute myocardial infarction（AMI） in Chinese minipigs from the aspects of hemodynamics and collagen ***:The left anterior descending（LAD）coronary artery was ligated to establish AMI model in Chinese *** and low doses of YXGF were administered to AMI minipigs *** group,model group and captopril group were also *** weeks after operation,blood pressure,hemodynamic parameters,collagen metabolism,vascular neuroendocrine and myocardial pathological changes were ***:HE staining showed that myocardial hypertrophy alleviated in all treatment groups,especially in high dose of YXGF group as compared with model *** investigation indicated that blood pressure（BP）, left ventricular pressure（LVP）and dp/dtmax,significantly declined in model and treatment group with low dose of YXGF and captopril as compared with sham group（P＜0.05,P＜0.01）,while LVP,BP and dp/dtmax in high dose of YXGF group significantly elevated as compared with model group（P＜0.01）,LVP in low dose of YXGF group and captopril group were much higher than that in model group（P＜0.05）,dp/dtmax in captopril group was higher than that in model group（P＜0.05）.Vascular neuroendocrine investigation showed that Ang Ⅱ concentration in myocardium of model group significantly increased as compared with sham group（P＜0.05）,while that in high dose of YXGF group and model group significantly declined as compared with model group（P＜0.05）.Investigation of collagen metabolism indicated that the total collagen of high dose of YXGF group,captopril group and model group significantly increased as compared with sham group（P＜0.05）,while that of treatment groups significantly declined as compared with model group（P ＜0.05,P＜0.01）.Compared with sham group,type Ⅲ procollagen contents in model group and all treatment group

关键词： Acute Myocardial Infarction Ventricular Remodeling yuxingeng fluid Chinese Minipigs

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Effect of yuxingeng fluid (愈心梗液) on Myocardial Energy Metabolism in Wistar Rats with Acute Myocardial Infarction

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Chinese Journal of Integrated Traditional and Western Medicine 2004年第1期10卷 52-54页

作者：董国菊刘剑刚史大卓 Xiyuan Hospital China Academy of Traditional Chinese MedicineBeijing(100091)

Objective: To examine the effect of yuxingeng fluid (愈心梗液, YXGF) on myocardial energy metabolism in Wistar rats with acute myocardial infarction (AMI) by observing the ultrastructure of mitochondria and the enzyme activities of rat myocardial adenosine triphosphate (ATP), succinate dehydrogenase (SDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and the content of glycogen. Methods; AMI models were established by ligature of left anterior descending coronary artery and then the rats with AMI were randomly divided into 7 groups: namely, blank group, model group, sham-operated group, captopil group, high-dose YXGF group, middle-dose YXGF group and low-dose YXGF group. From the next day after modeling, the rats were given YXGF through gastrogavage which lasted for 4 weeks. And then, the ultra-structure of mitochondria was observed by electronic microscope and the enzyme activities of ATP, SDH, ACP, ALP and the content of glycogen were determined. Results: Compared with model group, the other three groups of high-dose YXGF, middle-dose YXGF, low-dose YXGF and captopril group could protect the ultrastructure of mitochondria and significantly increase enzyme activities of ATP, SDH, ACP, ALP and the content of glycogen (P<0.01). Conclusion: YXGF can protect mitochondria and increase myocardial enzyme activities and the content of glycogen, which may be one of the mechanisms intervening in the pathological course of the early ventricular remodeling in rats with AMI.

关键词： yuxingeng fluid acute myocardial infarction myocardial energy metabolism

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