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Enhanced Healing of Full-thickness Diabetic Wounds Using Bioactive Glass and yunnan baiyao Ointments

Journal of Wuhan University of Technology(Materials Science) 2014年第5期29卷 1063-1070页

作者：毛葱 LIN Cai 陈晓峰 The National Engineering Research Center for Tissue Restoration and Reconstruction The School of Materials Science and Engineering South China University of Technology Department of Burns The First Affiliated Hospital of Wenzhou Medical University

In order to accelerate the chronic wounds healing, we investigated the healing effects of bioactive glass and Yuunan baiyao ointments in streptozotocin-induced diabetic rats. The ointments were prepared by mixing 45S5 bioactive glass powder （16% weight） with Vaseline and different weight percentages of Yurman baiyao. Full-thickness defect wounds were created on the back of 130 SD rats and were randomly divided into 8 groups. The wound healing rates were calculated at 4, 7, 10, 14 and 21 days after surgery. The samples were harvested for further observations. Considering the wound closure rate, group 6 （with 5% Yuunan baiyao） has better wound healing performance than other diabetic groups. The lower inflammatory response was observed by gross observation and confirmed by the results of H＆E staining and TEM observation. Besides, the proliferation of fibroblasts, the formation of granulation tissue, as well as the vascularization, were improved in group 6 compared to other diabetic groups. All results suggest that bioactive glass and yunnan baiyao ointments can accelerate the recovery of diabetes-impaired skin wounds, and comparing to other diabetic groups, group 6 （with 5% yunnan baiyao） has better healing effect.

关键词： bioactive glass yunnan baiyao diabetes mellitus wound healing

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Efficacy Observation on yunnan baiyao (云南白药) Combined with Antibiotics in Treating Helicobacter Pylori Related Duodenal Ulcer

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Chinese Journal of Integrative Medicine 2001年第1期7卷 36-38页

作者：黎红光李金庚 Tongcheng County Hospital Hubei

Objective: To observe the clinical efficacy of yunnan baiyao (云南白药, YNBY) combined with antibiotics in treating Helicobacter pylori (HP) related duodenal ulcer (DU). Methods: Eighty two HP positive DU patients were randomly divided into two groups: Treated group (44 cases) used YNBY plus amoxicillin and metronidazole; control group (38 cases) used de nol plus amoxicillin and metronidazole). Results: After a 2 week treatment course, the effect of epigastric pain relief was 68.3% in treated group, and 44.4% in control group, the difference between them was significant ( P <0.05). Marked effect in acid regurgitation and belching relief was observed in both groups. The rate of DU healing in treated and control group was respectively 88.6% and 89.5%; the clearance of HP 84.1% and 89.5%; and the side effects 4.5% and 13.5%, with insignificant difference between these two groups. Conclusion: YNBY combined with antibiotics in treating DU, and clearance of HP is an economic, safe and effective therapy.

关键词： duodenal ulcer helicobacter pylori yunnan baiyao antibiotics

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