检索结果-南通市图书馆

Effects of yue-bi-tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury

World Journal of Gastroenterology 2020年第43期26卷 6810-6821页

作者： Jing Hu Yu-Mei Zhang Yi-Fan Miao Lv Zhu Xiao-Lin Yi Huan Chen Xi-Jing Yang Mei-Hua Wan Wen-Fu tang Department of Integrative Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Traditional Chinese Medicine Xiang’an Hospital of Xiamen UniversityXiamen 361101Fujian ProvinceChina Animal Experiment Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The complications acute lung injury and acute kidney injury caused by severe inflammation are the main reasons of high mortality of severe acute pancreatitis(SAP).These two complications can both lead to water metabolism and acid-base balance disorders,which could act as additional critical factors affecting the disease ***(AQPs),which can regulate the transmembrane water transport,have been proved to participate in the pathophysiological process of SAP and the associated complications,such as acute lung injury and acute kidney ***,exploring herbs that can effectively regulate the expression of AQP in SAP could benefit the prognosis of this *** To determine whether yue-bi-tang(YBT)can regulate the water metabolism in rats with severe acute pancreatitis via regulating the expression of *** Sprague-Dawley rats were randomly divided into three groups,sham operation group(SOG),model group(MG),and treatment group(TG).SAP was induced with 3.5%sodium taurocholate in the MG and *** in the TG were administered with YBT while SOG and MG rats were given the same volume of *** and tissue samples were harvested to detect serum inflammatory cytokines,histopathological changes,malondialdehyde and superoxide dismutase in the lung,and protein and mRNA expression of kidney injury molecule-1,α-smooth muscle actin,and vimentin in the kidney,and AQP1 and 4 in the lung,pancreas,and *** The serum interleukin-10,tumor necrosis factorα,and creatinine levels were higher in the MG than in the *** necrosis factorαlevel in the TG was lower than that in the *** level in lung tissues was higher than in the *** pathological scores and edema scores of the pancreas,lung,and kidney tissues in the MG were all higher than those in the SOG and *** protein expression of AQP4 in lung tissues and AQP1 in kidney tissues in the MG were higher than those in the SOG and *** expression of vimentin was s

关键词： yue-bi-tang Aquaporins Sever acute pancreatitis Acute lung injury Acute kidney injury Water metabolism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：