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Study on the Effect of youguiyin(右归饮) on Regulating Gene Expression Profile of the Rats with Femoral Head Necrosis Induced by Steroid

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Chinese Journal of Integrative Medicine 2012年第4期18卷 269-275页

作者：吴承亮毛强金红婷肖鲁伟童培建 Zhejiang Traditional Chinese Medicine University Zhejiang Provincial Institute of Ortopaedics and Traumatology Ortopaedics and Traumatology Department of Zhejiang Provincial Traditional Chiese Medicine Hospital the First Affiliated Hospital of Zhejiang Traditional Chinese Medicine University

Objective： To observe the regulation of youguiyin （YGY, 右归钦） on the gene expression profile of the rat with steroid-induced femoral head necrosis （sFHN）, for the sake of investigating its molecular mechanism of sFHN prevention and treatment. Methods： All the 30 rats were randomly divided into three groups, the normal control group （A）, the model control group （B）, and the YGY treated group （C）, 10 in each group. After rats in Groups B and C were being made into FHN models with steroid injection, they received a daily intragastdc administration of saline and YGY respectively in equal volume for a total of 6 weeks, while to the unmodeled normal rats in Group A, saline was administered instead. The rats were sacrificed at the terminal of administration; their mRNA from femoral head tissue was extracted and prepared to cDNA probe through inverse transcription for detecting gene expression profile by microarray, outcomes of which was passing fluorescence quantitative PCR verification, and the differential expressed genes were analyzed adopting gene ontology （GO） method. Results： Compared with Group A, the numbers of differential genes found in Groups B and C were 190 and 92, respectively, but the changing trend in the two groups was opposite, mainly manifested as down-regulating in Group B/Group A （GB/GA） and up-regulating in Group C/Group B （GC/GB）. The analysis showed that these differential genes were mainly assigned to cell apoptosis, signal transduction, metabolism, cell proliferation and differentiation, cell cycle, blood coagulation, antioxidant activity, etc. Conclusions： sFHN was regulated by various genes; the regulation of YGY on expressions of these genes and the intra]extra-cellular signaling processes was possibly the molecular mechanism of YGY for preventing/treating sFHN. This study gave an explanation to the effectiveness of Chinese medicine in preventing/treating FHN from aspects of gene expression and enriched the Chinese medicine theory of ＂Kidney （Sh

关键词： youguiyin steroid-induced femoral head necrosis gene chip gene expression profile molecular mechanism

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Study of Different Patterns of Immuno-Modulatory Mechanism byTonifying Kidney and Invigorating Spleen Drugs

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Chinese Journal of Integrative Medicine 1998年第4期4卷 278-281页

作者：沈自尹蔡定芳张玲娟陈晓红钟历勇 Huashan Hospital Shanghai Medical University Shanghai Nanjing Rail-way Medical University Nanjing

Objective: To observe the acting pattern on the immune system by Kidney tonifying (KT) drugs. Methods: Three composite recipes were used on the 7- and 14-day corticosterone rat model to study the effect of recipes on the different patterns of immuno-modulatory and neuro- endocrinological systems. Results:The immune system of Spleen Invigorating(SI) group was well protected in either 7- or 14-day experiments,with the SI recipe showing no effect on the neuroendocrine system. It suggested that SI recipe might have direct action on immune system. On the other hand, KT group with no effect on neuroendocrine-immune (NEI) system in 7-day experiment, but showed a remarkable protective effect of the whole NEI system in 14-day experiment. Conclusion: The results indicated that KT recipe acts on the neuroendocrine system first, and then influence the immune system. It means that the action took place through down pathway of NEI network.

关键词： Kidney tonifying Spleen invigorating corticosterone rat youguiyin

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局部埋耳针治疗顽固性足跟痛123例

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中国中西医结合杂志 1997年第6期 374-375页

作者：节晓光贵阳中医学院第二附属医院

局部埋耳针治疗顽固性足跟痛１２３例贵阳中医学院第二附属医院（贵阳５５０００３）节晓光足跟痛是骨科的常见病多发病之一，诊断并不难，治疗方法亦多，但无论用何种方法治疗，仍有一部分患者成为顽固性足跟痛。１９８５年５月～１９... 详细信息

局部埋耳针治疗顽固性足跟痛１２３例贵阳中医学院第二附属医院（贵阳５５０００３）节晓光足跟痛是骨科的常见病多发病之一，诊断并不难，治疗方法亦多，但无论用何种方法治疗，仍有一部分患者成为顽固性足跟痛。１９８５年５月～１９９５年５月我院收治１２３例顽固性足...

关键词： tonify the Kidney invigorate the Spleen corticosterone rat youguiyin

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