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yolk sac tumor and Fanconi Anemia: Case Report

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Journal of Cancer Therapy 2021年第10期12卷 585-592页

作者： Chabchoub Imen Sboui Hiba Ammar Nouha Ben Abdeljalil Nouha Hochlef Makrem Belhassen Samia Zrig Ahmed Zakhama Abdelfattah Chabchoub Elyes Ben Ahmed Slim Department of Medical Onocology Faculty of Medecine Sousse University Hospital Farhat Hached Sousse Tunisia Department of Anathomopathology Faculty of Medecine Monastir University Hospital Fatouma Bourguiba Monastir Tunisia Department of Pediatric Surgery Faculty of Medecine Monastir University Hospital Fatouma Bourguiba Monastir Tunisia Department of Radiology Faculty of Medecine Monastir University Hospital Fatouma Bourguiba Monastir Tunisia Department of Genetics Faculty of Medecine Sousse University Hospital Farhat Hached Sousse Tunisia

yolk sac tumor (YST), which most frequently arises in the gonads as a type of germ cell tumor, is rare in children but is highly malignant. The common age group affected by yolk sac tumours is 11 to 24 years. In this study, we described a rare case of YST in terms of the clinical manifestation, imaging, and histopathology findings, diagnosis and treatment in a 12-year-old girl who was followed since birth for Fanconi-like syndrome. This is a rare clinical association that also limits chemotherapy.

关键词： Alpha-Fetoprotein Chemotherapy yolk sac tumor Pediatric Surgery Fan-coni-Like Syndrome

yolk sac tumor of the Ovary in 18 Egyptian Cases: Does It Really Differ?

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Journal of Cancer Therapy 2016年第4期7卷 247-253页

作者： Ahmed Elsayed Fathalla Hala Aziz Shokralla Department of Surgical Oncology National Cancer Institute Cairo Egypt Department of Medical Oncology National Cancer Institute Cairo Egypt

Background: Ovarian yolk sac tumor (OYST) is a rare entity of malignant ovarian germ cell tumors (MOGCT). Abdominal pain, a rapidly growing distending mass or irregular vaginal bleeding is the main presentation. Serum AFP is elevated in nearly all cases. The standard management is fertility preserving surgery with adjuvant chemotherapy. Aim of Work: To report and analyze retrospectively recorded cases that were either treated at National Cancer Institute/Egypt or referred there for advice about therapy. Materials and Methods: This is a retrospective single-institutional analysis of 18 cases of OYST treated at National Cancer Institute-Cairo University from January 2011 till December 2015. The clinical and pathological characteristics, treatment, and outcomes of these patients were analyzed. Results: Data from eighteen patients were obtained. The median age was 18 years (range: 15 - 22). Abdominal pain was the most common presentation (89%). The mean tumor size was 21cm (range: 8 - 30 cm). Eleven of our cases (61%) were stage I, seven cases and (39%) were stage IV at presentation. Fifteen cases (83%) underwent fertility preserving procedure & the standard surgical staging. Panhysterectomy & formal staging procedure was done only in two cases (11%). One case (6%) underwent bilateral salpingo-oophorectomy. 2 cases (11.1%) only underwent lymph node biopsy. 11 patient (61.1%) showed pure type YST while mixed type was present in the remaining 7 cases (38.8%): Dysgerminoma (one case, 5.6%), Dysgerminoma + immature teratoma (one case, 5.6%), Immature teratoma (2 cases, 11.1%) and Teratoma (3 cases, 16.7%). AFP was extremely elevated in all cases at presentation (median 4191 ng/mL;ranging: 725 ng/mL - 402,908 ng/mL). It showed decreased level after surgery (median 145 ng/ mL;ranging: 2 ng/mL - 38,000 ng/mL) & normalized after chemotherapy except for progressive disease. All cases started BEP regimen after surgery with complete remission in twelve cases. In follow up period (

关键词： yolk sac tumor Ovary Outcomes

yolk sac tumor in an infant with Androgen Insensitivity Syndrome:a case report and review of the literature

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Yolk Sac Tumor in an infant with Androgen Insensitivity Synd...

Refractory Ascites Revealing an Ovarian yolk sac tumor with Intraperitoneal Rupture

2020年浙江省医学会小儿外科学术大会暨浙江省医师协会小儿外科医师学术大会暨浙江省抗癌协会小儿肿瘤专业委员会学术大会

作者：冯召广杨华军楼毅王爱和刘伟光杭州市儿童医院小儿外科

Androgen insensitivity syndrome(AIS) is the most common cause of male pseudohermaphroditism and the third most common cause of primary *** present report describes a 8-month-oldchild with a female phenotype and a 46,XY karyotype,presenting with bilateral inguinal *** ultrasonography(US) found a solid mass suspected to be a testicular tumor of the right hernia sac and a testis of the left hernia sac,*** tomography showed a solid inguinal mass measuring 3.6 x 2.4 cm in the right and 1.6 x 1.1 cm in the left side,with homogeneous *** alpha-fetoprotein(AFP) was 2449 ng/mL,while β-human chorionic gonadotrophin(HCG) was ***,bilateral inguinal herniawas the primary *** patient underwent right radical inguinal orchiectomy with high ligation of the spermatic cord and laparoscopic percutaneous extra-peritoneal *** pathology confirmed a pure yolk sac tumor(YST) from the right *** follow-up ultrasonography shown no recurrence,with serum AFP returned to normal within 3 *** case we presented is very rarely reported in the literature with yolk sac tumor in a AIS children presented with a palpable lump inguinal region.

关键词： androgen insensitivity syndrome disorder of sex development(DSD) laparoscopic bilateral inguinal hernia yolk sac tumor

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Open Journal of Pathology 2023年第2期13卷 93-99页

作者： Vahatra Joëlle Razafimahefa Herilalao Elisabeth Razafindrafara Tojo Rémi Rafaralahivoavy Tsitohery Francine Andriamampionona Nantenaina Soa Randrianjafisamindrakotroka Department of Pathology CHU Andrainjato Fianarantsoa Madagascar Department of Pathology Soavinandriana Hospital Center Antananarivo Antananarivo Madagascar Department of Radiology CHU Andrainjato Fianarantsoa Madagascar Department of Pathology Medical School of Antananarivo Antananarivo Madagascar

yolk sac tumors of the ovary are rare entities that account for 2% - 5% of all ovarian tumors. They represent the second most common histological variant of malignant germ cell tumors of the ovary after dysgerminomas. yolk sac tumors are most commonly encountered in women in the second and third decades. Microscopically, they are highly polymorphic and can present in a pure form or associated with another contingent of germ cell tumor. We report the case of a 26-year-old woman, who underwent surgery for a large right ovarian tumor rupturing into the peritoneal cavity. The ovarian tumor was revealed by ascites of great abundance and abdomino-pelvic pain. On histological examination, the diagnosis of yolk sac tumor in its pure and polyvesicular vitelline pattern was made. Through this observation, we propose to discuss the anatomoclinical particularities of these tumors by emphasizing the importance of histology for the diagnosis as well as the need of an early and appropriate management.

关键词： Germ Cell tumor yolk sac tumor Ovary Abdominal Distension Schiller-Duval Ascite

A case report of primary mediastinal yolk sac tumor

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Journal of Medical Colleges of PLA(China) 2004年第5期19卷 320-320页

作者：李小飞刘锟程庆书汪健 Department of Thoracic Surgery Tangdu Hospital Fourth Military Medical UniversityXian 710038China

Primary yolk sac tumor of the mediastinum is very rare. yolk sac tumor is highly malignant, and has less chance of operation. One case, which treated in this institute since 1954, is retrospectively studied to investi... 详细信息

关键词： mediastinum yolk sac tumor

Clinicopathologic Characteristics and Survival of Patients with Rare Malignant Ovarian yolk sac tumors:A Population-based Analysis

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Current Medical Science 2021年第2期41卷 342-347页

作者： Tian WANG Bo WANG Shi-xuan WANG Ming-fu WU Deparment of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

yolk sac tumors (YSTs) are rare malignant germ cell tumors that usually affect youngfemales. To date, there have been few studies on YSTs. We evaluated the relationship betweenclinicopathologic characteristics of patients with ovarian YSTs and disease outcome based onSurveillance, Epidemiology, and End Results data. The K aplan-Meier method and log-rank testwere used to evaluate differences in survival rates. Data for 269 patients were analyzed. Theincidence of YSTs among ovarian germ cell tumors (OGCTs) cases was 0.4%;median patient agewas 22.0 years, and most tumors were unilateral. Patients presented with distant metastasis (37.5%),localized disease (49. 1%), and regional spread (8.9%). American Joint Committee on Cancer stagewas available for 13 patients (stage IA, n=2;stage IC, n=1;stage IA, n=1;stage IB, n=3;stageIlC, n=2;and stage IV, n=4). Survival rates at 1, 3, and 5 years were 91.0%, 84.0%, and 83.2%,respectively, for overall survival (OS) and 92.0%, 85.4%, and 84.5%, respectively, for disease-specific survival (DSS). The 5-year OS and DSS of patients with ovary tumors were 91.5% and92.9%, respectively, compared to 74.8% and 77.2%, respectively, for those with extra-ovarianspread (P50 years was associated with shorter OS and DSS(both P<0.001), whereas no associatios of OS and DSS were observed with pathologic grade (P=0.49for OS and 0.52 for DSS). In summary, YSTs are typically unilateral, of a high grade, and localizedto the ovary;extra-ovarian spread has a poor outcome, and postmenopausal women have worseprognosis than premenopausal women.

关键词： yolk sac tumor clinical characteristic prognosis SEER

Laparoscopic uncontained power morcellation-induced dissemination of ovarian endodermal sinus tumors:A case report

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World Journal of Clinical Cases 2021年第13期9卷 3212-3218页

作者： Ha Kyung Oh Seong Nam Park Byoung Ryun Kim Department of Obstetrics and Gynecology Wonkwang University HospitalIksan 54645Jeollabuk-doSouth Korea

BACKGROUND Endodermal sinus tumors(ESTs),which arise primarily in children and adolescents,account for 20%of malignant ovarian germ cell tumors,but constitute only 1%of all ovarian *** of ESTs consists of surgical staging with fertility-sparing surgery and *** SUMMARY A 15-year-old nulliparous patient was diagnosed with disseminated ovarian ESTs after laparoscopic unilateral salpingo-oophorectomy using uncontained power morcellation for treatment of a ruptured solid adnexal mass in another *** laparotomy;total abdominal hysterectomy,right salpingooophorectomy,and lymphadenectomy were performed with optimal debulking,and surgical stage 3C was assigned to the *** In 2014,the Food and Drug Administration noted that power morcellation was probably associated with a risk of disseminating suspected cancerous ***,the use of power morcellation to remove solid adnexal mass is considered a contraindication because of the potential for a malignant *** case report aims to warn of the dangers of using uncontained power morcellation to treat solid adnexal masses.

关键词： Dissemination Endodermal sinus tumor Morcellation yolk sac tumor Case report

Non-seminomatous germ cell tumor with bone metastasis only at diagnosis:A rare clinical presentation

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Asian Journal of Urology 2017年第2期4卷 124-127页

作者： K.C.Biebighauser Jianjun Gao Priya Rao Gene Landon Lance Pagliaro Colin PNDinney Jose Karam Neema Navai The University of Texas Medical School at Houston HoustonTXUSA Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Division of Medical Oncology Department of OncologyMayo ClinicRochesterMNUSA Department of Urology The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Bone metastasis of non-seminomatous germ cell tumors(NSGCT)of the testes is a rare event and even more uncommon at initial ***,bone lesions are discovered in the presence of concurrent retroperitoneal lymph node or visceral ***,in this case,a 37 years old male complaining of a growing testicular mass was found to have isolated bone metastasis with associated caudaequina syndrome without apparent abnormal findings on initial computed tomography(CT)*** neurologic symptoms prompted further evaluation with magnetic resonance imaging(MRI),which demonstrated multiple sites of bone metastasis without evidence of retroperitoneal lymph node or visceral organ *** case represents a rare clinical presentation and disease manifestation of NSGCT.

关键词： Testis cancer Metastasis Non-seminomatous yolk sac tumor

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小儿骶尾部畸胎瘤(附86例报告)

中华小儿外科杂志 1984年第1期5卷 10-12页

作者：梁猷惠覃均昌刘正全张德文重庆医学院儿科医院外科

This paper presents summary of the authors'experience in treating 86 cases of sacrococcygeal teratoma as well as an analysis together with 191 such cases reported in Chinese medical literature since *** analysis shows 230 of them were benign(83%)and 47 were malignant(17%),the ratio of male to female being 1:2.6. According to the symptoms and findings at *** tumors can be divided into 5 *** the authors'cases,74 were benign(86%)and 12 malignant(14%).The follow-up of 64 cases has an average length of 5 yrs and 7 mons,the longest being 14 yrs and 6 mons,and the shortest half a year All the 12 with malignant tumors died 20 *** seven months after the operation.2 with benign tumors died of their recurrence respectiveIy 2 and 2 1/2 yrs after the *** remaining patients except one who died of some other disease are surviving,growing and developing well. It is found that older age would see higher incidence of *** 29 malignant cases with age records available,25 were over 4 mons old(86.2%).The authors also found that prognosis is closely related to the time of the occurrence of the *** the tumor did not appear until 2 months after birth,it would tend to become malignant.13 out of 19 such cases(s8.4%)proved *** 159 cases with the tumors appearing within 2 months,only 16 were realignant(10.1%) The authors noted that sacrococcygeal tera toma is always combined with yolk sac tumor which can produce AFP,which makes its level higher than nortonl in affected *** removal of the tumor will bring down AFP level back to *** recurrence will raise it ***,determination of AFP in serum helps much to confirm the diagnosis and predict the prognosis.

关键词：小儿骶尾部畸胎瘤 Children medical literature 文献报告 malignant tumors analysis yolk sac tumor would level found experience surviving AFP 性别临床资料 presents summary related