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Experimental Study of yishou tiaozhi tablet(益寿调脂片) on Free Radical Metabolism in Aging Model Mice

Chinese Journal of Integrative Medicine 2000年第4期6卷 283-286页

作者：朱秉匡孙立郑仕富张荣华 The First Hospital of Medical College Jinan University Medical College Jinan University

Objective： To observe the effect of yishou tiaozhi tablet（YSTZT） on the metabolism of free radical in mice of aging model. Methods: Using the aging model induced by hypodermic injection of 5%D-glalactose in mice for forty days. The content of malondialdehyde(MDA) and activity of superoxide dismutase(SOD), glutathione peroxidase (GSH-Px) in serum, activity of monoamine oxidase B (MAO-B), Na+-K+-ATPase in brain were investigated after treatment. Results: Compared with the aging model group, it showed that YSTZT could obviously inhibit the increase of level of MDA in serum and the activities of MAO-B in brain; and enhance the activities of SOD,GSH-Px in serum, and the activities of Na+-K+-ATPase in brain. Furthermore, YSTZT could obviously elevate the tolerance to fatigue and hypoxia in mice. Conclusion: YSTZT could effectively improve the free radical metabolism of senile body, it is an ideal and effective medicine in preventing aging, which is also one of the experimental basis in proving the theory of 'Spleen and Kidney Deficiency complicated with Stasis and Phlegm causes aging'.

关键词： yishou tiaozhi tablet aging model free radical

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Experimental Study of yishou tiaozhi tablet(益寿调脂片) on Inhibiting Hyperlipemia and Atherosclerosis

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Chinese Journal of Integrative Medicine 2001年第1期7卷 43-47页

作者：钟毅朱秉匡郑仕富 Guangdong Provincial TCM Hospital Institute of Integrated Traditional Chinese and Western Medicine on Qi and Blood in Jinan University

Objective: To observe the effect of yishou tiaozhi tablet(YSTZT) on lipid metabolism and aortic intimal atherosclerotic plaque coverage in rabbit model of experimental hyperlipemia and ***: Thirty two rabbits were randomly divided into four groups, Group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day;for Group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C, hyperlipid forage was given and for Group D, only ordinary forage was given. Biochemical parameters were measured and pathomorphological examinations were carried out 6 weeks ***: (1) YSTZT obviously lowered the levels of serum total cholesterol(TC), triglyceride(TG), atherosclerotic index(AI), apoprotein(ApoB), lipoprotein [Lp(a)], oxygen low density lipoprotein cholesterol(ox LDL), hydroxyproline(HYP), plasma Ca 2+ , thromboxane B 2(TXB 2), and increased the levels of serum high density lipoprotein cholesterol(HDL C), apoprotein A 1(Apo A 1), ApoA 1 /ApoB, plasma 6 keto PGF 1α ( P <0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and arterial intima thickness were obviously reduced, smooth muscle cell hyperplasia and elastic fibers were not ***: YSTZT can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.

关键词： yishou tiaozhi tablet hyperlipemia atherosclerosis

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