检索结果-南通市图书馆

Efficacy of yiqigubiao pill on chronic obstructive pulmonary disease in rats with the disease induced by lipopolysaccharide and cigarette-smoke fumigation

引用

Journal of Traditional Chinese Medicine 2020年第6期40卷 983-991页

作者： Jiang Lin Li Fengsen Sun Jianhui Huo Hairu Li Xiaoqin Li Hongmei Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region Urumqi830000China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

OBJECTIVE:To investigate the efficacy of yiqigubiao pill(YQGB)on chronic obstructive pulmonary disease(COPD)in rats with the COPD induced by lipopolysaccharide(LPS)and cigarettesmoke ***:In this study,six groups of rats were set up,including control group,model group,positive control group(aminophylline)and YQGB(high,medium and low doses)*** injection of lipopolysaccharide(LPS)and cigarette-smoke fumigation induced COPD in *** general condition,incubation period and coughing times,lung function,level of inflammatory factors,leukocyte condition and pathological changes of bronchus and lung tissue were observed in rats of each ***:In the COPD rats,the latent period of coughing was shortened and the cough frequency was increased significantly;the pulmonary function was significantly decreased,which was manifested by the increased lung tissue resistance and respiratory system resistance,and the decreasing percentage of forced expiratory volume and forced expiratory volume in the 0.3 s(FEV0.3/FVC);the contents of tumor necrosis factor-alpha(TNF-α)and interleukin-4 in serum were obviously increased,and the NEUT%in bronchoalveolar lavage fluid was significantly *** could obviously prolong the latent period of cough,and reduce the cough frequency and the content of TNF-αin *** can also significantly reduce respiratory resistance and increase FEV0.3/FVC *** results of histopathology showed that YQGB significantly reduced the pathological changes of tracheal mucosa and lung caused by *** obviously increased level of AQP1,which was down-regulated in the COPD ***:YQGB could significantly improve the pulmonary function,reduce inflammation and alleviate lung and bronchial diseases in the COPD rats.

关键词： Pulmonary disease chronic obstructive Respiratory function tests Bronchoalveolar lavage fluid Inflammatory cytokines yiqigubiao pill

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：