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yimu san improves obstetric ability of pregnant mice by increasing serum oxytocin levels and connexin 43 expression in uterine smooth muscle

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第11期18卷 986-993页

作者： Qi-huan WANG Shuang ZHANG Li-meng QIN Wen-jun ZHANG Feng-hua LIU Jian-qin XU Yun-fei MA Ke-dao TENG College of Veterinary Medicine China Agricultural University College of Animal Science and Technology Beijing University of Agriculture

Prolonged farrowing remains one of the critical challenges in intensive pig farming. This study aims to explore the effects and mechanism of yimu san （YMS）, a Chinese veterinary medicine micro mist, on delivery ability with mouse models. Thirty-two pregnant mice were randomly divided into a control group and Iow-YMS, med-YMS, and high-YMS groups. The labor process time and stillbirth rate were recorded, the levels of serum oxytocin and prostaglandin E2 （PGE2） were measured with enzyme-linked immunosorbent assay （ELISA）. Contractility measure- ments of the isolated uterus and the expression of connexin 43 （Cx43） in uterine smooth muscle were evaluated. The results showed that compared with the control group, the birth process time and stillbirth rate in the med-YMS and high-YMS groups were remarkably lower. The in vitro uterine contractions, levels of oxytocin, PGE2, and Cx43 in the med-YMS and high-YMS groups were significantly higher than those in the control group. The differences of the above measurements between the Iow-YMS group and the control group were not obvious. It can be speculated that YMS could significantly promote labor in pregnant mice by enhancing the levels of oxytocin, Cx43, and PGE2.

关键词： yimu san Delivery ability Uterine contraction Oxytocin Prostaglandin 52 Connexin 43

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