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Emerging role of Hippo pathway in gastric and othergastrointestinal cancers

World Journal of Gastroenterology 2016年第3期22卷 1279-1288页

作者： Wei Kang Alfred SL Cheng Jun Yu Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory in Oncology in South ChinaLi Ka Shing Institute of Health ScienceSir Y.K.Pao Cancer CenterInstitute of Digestive DiseasePartner State Key Laboratory of Digestive DiseasePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Institute of Digestive DiseasePartner State Key Laboratory of Digestive DiseasePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

More evidence has underscored the importance of Hippo signaling pathway in gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. yes-associated protein 1(YAP1) and its close paralog TAZ, transcriptional co-activator with a PDZbinding motif, function as key effectors negatively controlled by the Hippo pathway. YAP1/TAZ exerts oncogenic activities by transcriptional regulation via physical interaction with TEAD transcription factors. In various cancers, Hippo pathway cross-talks with pro- or anti-tumorigenic pathways such as GPCR, Wnt/β-catenin, Notch and TGF-β signaling and is deregulated by multiple factors including cell density/junction and micro RNAs. As YAP1 expression is significantly associated with poor prognosis of gastric and other gastrointestinal cancers, detailed delineation of Hippo regulation in tumorigenesis provides novel insight for therapeutic intervention. In current review, we summarized the recent research progresses on the deregulation of Hippo pathway in the gastrointestinal tract including stomach and discuss the molecular consequences leading to tumorigenesis.

关键词： Hippo signaling pathway yes-associatedprotein 1 MicroRNA Oncogenic role Tumor suppressor

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