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yangxin dawayimixike honey paste inhibits atherosclerosis in ApoE^(-/-)mice by attenuating blood lipids and exerting anti-inflammatory activity

引用

Traditional Medicine Research 2022年第2期7卷 27-33页

作者： Yu Ding Jin-Rong He Jie Liu Shan-Shan Chen Jin Huang Hai-Long Yin Tong Yu Xin-Hai Jiang Jin-Que Luo Yan-Ni Xu Qiang Yin Key Laboratory for Molecular Diagnosis of Hubei Province Wuhan 430014China Central Laboratory The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of Pathology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Xinjiang Uighur Pharmaceutical Limited Company Urumq 830001China Department of Traditional Chinese Medicine Humanwell Healthcare(Group)Co.Ltd.Wuhan 430075China NHC Key Laboratory of Biotechnology of Antibiotics National Center for New Microbial Drug ScreeningInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical College(CAMS&PUMC)Beijing 100050China.

Background:yangxin dawayimixike honey paste(YDHP)is a representative traditional Chinese medicine,and its main function is curing angina pectoris,palpitation and ***,it is unclear whether YDHP can suppress the development of *** aim of this study was to validate the potential application of YDHP in atherosclerosis therapy and search for its potential ***:Seven-week-old ApoE^(-/-)mice were randomly divided into a normal group fed a normal diet,an atherosclerosis model group fed a high-fat diet,YDHP groups fed a high-fat diet mixed with different doses of YDHP and positive control groups fed a high-fat diet mixed with atorvastatin or *** feeding for 10 weeks,body weight,blood lipids,liver and kidney function indexes,serum inflammatory cytokines and atherosclerotic plaque areas were *** metabolic profiles were detected by an automatic biochemical *** inflammatory cytokines were quantified by enzyme-linked immunosorbent assay *** plaque areas were analysed using Oil Red O ***:The YDHP(200,400 and 800 mg/kg/d)treated groups showed reduced serum levels of low density lipoprotein-cholesterol(P<0.05,when 200 or 400 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 800 mg/kg/d of YDHP group compared with the atherosclerosis model group),total cholesterol(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP group compared with the atherosclerosis model group)and triglyceride(P<0.01),however,elevated serum levels of high-density lipoprotein cholesterol(P<0.01)compared to the atherosclerosis model *** inhibited the area of atherosclerotic *** addition,YDHP suppressed the levels of serum inflammatory cytokines such as interleukin 6(P<0.05,when 200 mg/kg/d of YDHP group compared with the atherosclerosis model group;P<0.01,when 400 or 800 mg/kg/d of YDHP g

关键词： yangxin dawayimixike honey paste atherosclerosis blood lipid anti-inflammation safety side effects

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