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Integrated evaluation of HPLC fingerprints for the quality control of Ginseng yang Rong Wan by multi-wavelength fusion fingerprint method

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Asian Journal of Traditional Medicines 2019年第4期14卷 171-182页

作者： Hanxiao Chi Guoxiang Sun School of Pharmacy Shenyang Pharmaceutical UniversityShenyangLiaoningChina

The aim of this study was to develop comprehensive evaluation methods for the quality control of Ginseng yang Rong Wan(RSYRW).Multi-wavelength fusion fingerprints were successfully developed by high-performance liquid chromatography,which avoided the one-sidedness of single *** fingerprints of thirty batches of samples were generated at five wavelengths and evaluated by quantified ratio fingerprint method(QRFM).The results showed that thirty batches of samples were classified into seven *** methods established in this paper were found suitable for the analysis of Ginseng yang Rong Wan.

关键词： Ginseng yang Rong Wan quantified ratio fingerprint method traditional Chinese medicine

Nonlinear Super Integrable Couplings of Super yang Hierarchy and Its Super Hamiltonian Structures

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Journal of Applied Mathematics and Physics 2017年第4期5卷 792-800页

作者： Sixing Tao Yunling Ma School of Mathematics and Statics Shangqiu Normal University Shangqiu China

Nonlinear super integrable couplings of the super yang hierarchy based upon an enlarged matrix Lie super algebra were constructed. Then its super Hamiltonian structures were established by using super trace identity. ... 详细信息

关键词： Lie Super Algebra Nonlinear Super Integrable Couplings Super yang Hierarchy Super Hamiltonian Structures

A Hypothetical Anti-Aging Mechanism of “yang-Invigorating” Chinese Tonic Herbs

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Chinese Medicine 2012年第1期3卷 72-78页

作者： Philip Y. Lam Hoi Shan Wong Jihang Chen Kam Ming Ko Division of Life Science The Hong Kong University of Science & Technology Hong Kong China

Chinese tonic herbs are generally classified into Yin and yang categories based on their health-promoting action. Emerging evidence has suggested that in addition to up-regulating mitochondrial functional status, yang tonic herbs also enhance cellular/mitochondrial antioxidant capacity, and may thus prevent age-related diseases and prolong the healthy part of lifespan (i.e. healthspan). The proposed biochemical mechanism underlying the antioxidant action of yang tonic herbs involves a sustained and low level of mitochondrial reactive oxygen species production, which is secondary to the increased activity of the electron transport chain, with the possible involvement of mitochondrial uncoupling. “yang invigoration” improves antioxidant defense in the body in the long term and thereby offers a promising prospect for preventing or possibly delaying age-related diseases and the detrimental effects of aging.

关键词： Chinese Medicine yang Mitochondrial Decay Age-Related Diseases

Differential Effects of Yin- and yang-Chinese Tonifying Herbs on Innate and Adaptive Immunity

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Chinese Medicine 2023年第2期14卷 68-78页

作者： Hoi Yan Leung Kam Ming Ko Division of Life Science Hong Kong University of Science & Technology Hong Kong China

The present study investigated the effect of treatment with methanolic extracts of Yin- and yang-Chinese tonifying herbs on concanavalin A (Con A)/lipopolysaccharide (LPS)-stimulated splenocyte proliferation (adaptive immunity) and natural killer (NK) cell activity (innate immunity) in an ex vivo mouse model. The results indicated that while treatment with most Yin herbal extracts potentiated the Con A/LPS-stimulated splenocyte proliferation, only yang (but not Yin) herbal extracts stimulated NK cell activity. The differential effects of Yin- and yang-Chinese tonifying herbs on innate and adaptive immunity are consistent with the Chinese medicine theory which depicts the Yin and yang functional components of Zheng Qi (vital energy), with the yang component being responsible for the first line of defense against invading microorganisms (i.e., innate immunity) and the Yin oner serving as a follow-up defensive response (adaptive immunity).

关键词： Yin yang Innate Immunity Adaptive Immunity Natural Killer Cell Activity Splenocyte Proliferation

Differential Effects of Ursolic Acid and Oleanolic Acid on Mitochondrial ATP Generation in H9c2 Cardiomyocytes and Lipopolysaccharide-Induced Cell Proliferation in Mouse Splenocytes: yang versus Yin

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Chinese Medicine 2021年第3期12卷 37-46页

作者： Hoi Yan Leung Kai Chit Cheung Kam Ming Ko Division of Life Science Hong Kong University of Science & Technology Hong Kong China

In the present study, two cell-based systems for assessing yang and Yin activities were for the first time used to investigate the effect of ursolic acid (UA) and oleanolic acid (OA). The results indicated that while ... 详细信息

In the present study, two cell-based systems for assessing Yang and Yin activities were for the first time used to investigate the effect of ursolic acid (UA) and oleanolic acid (OA). The results indicated that while UA was only active in the Yang assay, OA produced activity in the Yin assay. The Yang/Yin activity of UA/OA may be attributed to their distinct molecular structures, which confer their differential ability to interact with mitochondrial membrane or cellular membrane lipids, with resultant membrane fluidization and potentiation of biological responses.

关键词： yang Yin Ursolic Acid Oleanolic Acid Mitochondrial ATP Generation Splenocytes

Mathematical Reasoning of Treatment Principle Based on “Yin yang Wu Xing” Theory in Traditional Chinese Medicine (II)

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Chinese Medicine 2011年第1期2卷 158-170页

作者： Yingshan Zhang 不详

By using mathematical reasoning, this paper demonstrates the treatment principle: “Do not treat a disease after it has occurred. But treat the disease before it will occur” (不治已病治未病) based on “Yin yang Wu Xing” Theory in Traditional Chinese Medicine (TCM). We defined generalized relations and reasoning, introduced the concept of generalized steady multilateral systems, and discussed its energy properties. Later based on the treatment of TCM and treated the healthy body as a steady multilateral system, it has been proved that the treatment principle above is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.

关键词： Traditional Chinese Medicine (TCM) “Yin yang Wu Xing” Theory Steady Multilateral Systems Opposite Relations Side-Effects Medical and Drug Resistance Problem

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Primary Study on the Protection and Development Planning of Antiquity Gardens——A Case Study of "Temple of yang Shengan and Guihu Lake"

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Journal of Landscape Research 2009年第4期1卷 66-70页

作者：刘雅平石学丽罗言云四川大学生命科学学院四川成都610064 新都杨升庵博物馆四川成都610500

Through exploring and studying the rebuilding and protection planning of the Temple of yang Shengan and Guihu Lake,the design principles and experience of rebuilding and protecting gardens of antiquity were summarized,the effective approaches to integrate the rebuilding design and the protection of relics were explored and the suggestions for the protection and development of antiquity gardens were put forward.

关键词： Garden of antiquity yang Shengan Guihu Lake Protection and development

‘yang-Invigorating’ Chinese Tonic Herbs Enhance Mitochondrial ATP Generation in H9c2 Cardiomyocytes

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Chinese Medicine 2011年第1期2卷 1-5页

作者： Hoi Shan Wong Hoi Yan Leung Kam Ming Ko 不详

‘yang-invigorating’ Chinese tonic herbs have been shown to enhance the myocardial mitochondrial ATP generation capacity in mice ex vivo. In the present study, we examined the effect of treatment with the methanol extract of ‘yang-invigorating’ herbs on mitochondrial ATP generation capacity in H9c2 cardio-myocytes. The effect of ‘Yin-nourishing’ herbs was also investigated for comparison. The results indicated that all ‘yang-invigorating’ Chinese tonic herbs dose-dependently enhanced the mitochondrial ATP genera-tion capacity in H9c2 cardiomyocytes. Three out of nine ‘Yin-nourishing’ herbs produced a dose-dependent stimulatory effect on ATP generation, but to lesser extents than those of yang herbs. Results obtained from activity-directed fractionation of the three most potent ‘yang-invigorating’ herbs suggested that the ATP-stimulating ingredients were rather water insoluble and largely resided in the butanol fraction. In con-clusion, ‘yang-invigorating’ herbs invariably stimulated mitochondrial ATP generation capacity in H9c2 cardiomyocytes. The cell-based assay of ATP generation capacity may be used as pharmacological test for ‘yang-invigorating’ Chinese tonic herbs.

关键词： yang Yin Chinese Medicine ATP Mitochondria Cardiomyocytes

Proteomics analysis of IBS-D with spleen and kidney yang deficiency

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Journal of Traditional Chinese Medical Sciences 2017年第1期4卷 39-49页

作者： Yijie Li Xiaolan Su Peng Wu Jifeng Wang Yu Guo Jiajie Zhu Qingguo wang Jiande Chen Fuquan yang Wei Wei Beijing University of Chinese Medicine Beijing 100029China Gastroenterology Department WangJing HospitalChinese Academy of Traditional Chinese MedicineBeijing 100102China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Johns Hopkins University School of Medicine BaltimoreMD 21224USA

Objective:To investigate the molecular mechanism underlying the development of diarrhea-predominant irritable bowel syndrome (IBS-D) with spleen and kidney yang deficiency (SKYD) using a proteomics ***:Male Sprague-Dawley rats (n =22) were divided into IBS-D (n =12) and normal control (n =10) *** was then modeled in IBS-D rats by a combination of acetic acid enema,bondage,rectal dilation,tail stimulation,and Senna *** tissue samples were subsequently collected and examined by Q Exactive mass spectrometry to identify differentially expressed proteins between the two ***:The occurrence of SKYD/IBS-D was associated with ribosomal protein S23 (Rps23),protein phosphatase 2 catalytic subunit alpha (Pp2a),and growth factor receptor-bound protein 2 (Grb2),which are involved in the ribosome,neurotrophin signaling,and Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling ***:These data suggest that SKYD/IBS-D pathophysiology likely involves inflammation,cell growth,apoptosis,stress granule formation,immune activation,loss of epithelial cell integrity,and visceral hypersensitivity.

关键词： Spleen and kidney yang deficiency IBS-D Proteomics Mechanism