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Unique MicroRNAs Signature of Lymphocyte of yang and Yin Syndromes in Acute Ischemic Stroke Patients

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Chinese Journal of Integrative Medicine 2019年第8期25卷 590-597页

作者： ZHAO Hai-ping LIU Ping XU Chang-min LI Guang-wen GAO Li LUO Yu-min Cerebrovascular Diseases Research Institute and Department of Neurology Xuanwu Hospital of Capital Medical University Beijing (100053)China Beijing Geriatric Medical Research Center Beijing (100053)China Beijing Institute for Brain Disorders Beijing (100053)China Key Laboratory of Neurodegenerative Diseases of Ministry of Education and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases Beijing (100053)China

Objective: To identify the differentially expressed microRNAs (miRNAs) profiles of yang and yin syndromes in patients with acute ischemic stroke, and to provide the molecular basis of the classification of these two syndrome types in acute ischemic stroke patients. Methods: A microarray assay was performed to assess the expression pattern of miRNAs in the lymphocyte of acute ischemic stroke patients. Target genes for the deregulated miRNAs were predicated using the online bioinformatic algorithms and functional annotation via Kyoto encyclopedia of genes and genomes pathway analysis for miRNAs predicted targets was carried out. Based on the predicted target genes of differentially expressed miRNAs, the miRNA-gene-network and miRNA-pathway network were constructed. Results: yang score based on tongue texture, urine, dejecta, and appearance, etc. showed that clinical symptoms were distinct between yang and yin syndromes. There were significantly higher total leukocyte number and lower total protein level in patients with yang syndrome compared with those in patients with yin syndrome (Pyang syndrome group, and 20 unique down-regulated and 2 unique up-regulated miRNAs in yin syndrome group. The key regulatory miRNAs, gene, and pathways in the yang syndrome were hsa-miR-93-5p and -320b, enabled homolog, the metabolic pathways and mitogen-activated protein kinase signaling pathways, respectively, while those in the yin syndrome were hsa-miR-424-5p and -106b-5p, CNOT4, hepatitis B and pathways in cancer, respectively. Conclusion: These results offered insight into the molecular basis underlying the different pathogenesis of yang or yin syndrome, providing clues for the individualized therapeutic strategies of acute ischemic stroke.

关键词： acute ischemic stroke yang syndrome yin syndrome microRNAs profile diagnosis Chinese medicine

Mechanism underlying treatment of diabetic kidney disease using Traditional Chinese Medicine based on theory of Yin and yang balance

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Journal of Traditional Chinese Medicine 2018年第5期38卷 797-802页

作者： Piao Yuanlin Yin Dehai Department of Traditional Chinese Medicine Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences

The pathogenic mechanism of diabetic kidney disease(DKD) is complex. The development of DKD cannot be fully explained by a single *** Chinese Medicine(TCM) has been applied extensively for the treatment of DKD in ***, studying the mechanism of DKD using theories and methods that are appropriate for TCM characteristics and searching for theoretical bases for TCM clinical application are topics that still need to be explored and researched. Activation of the transforming growth factor(TGF)-β1/Smad and PI3 K/Akt/mTOR signaling pathways functions as a self-protection mechanism against renal microinflammation in DKD. However, the persistent abnormal overactivation of reactions causes secondary cell dysfunction, cell apoptosis, increased extracellular matrix(ECM) secretion, and eventually renal fibrosis. During this process, the dysregulation of self-balance among a variety of signaling pathways and the loss of self-feedback regulatory mecha-nisms downstream of these signaling pathways are critical causes of the occurrence and development of DKD. TCM may both inhibit the expression or activation of "hyperactive" signaling pathways(NFB, Smad3, and PI3 K/Akt/mTOR) and increase the expression or activation of "deficient" signaling pathways(Smad7 and PTEN) to restore balance to cells with an abnormal pathophysiological status and achieve the goal of DKD treatment.

关键词： Diabetic kidney disease Traditional Chinese Medicine Yin and yang theory

Contributions of Lo yang to Value Distribution Theory

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Acta Mathematica Sinica,English Series 2019年第10期35卷 1573-1585页

作者： Yuan WANG Jian Yong QIAO Jing yang Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China Beijing University of Posts and Telecommunications Beijing 100876P.R.China Department of Basic Courses Beijing Union UniversityBeijing 100101P.R.China

Professor Lo yang is a world famous mathematician of our country. He made a lot of outstanding achievements in the value distribution theory of function theory, which are highly rated and widely quoted by domestic and foreign scholars. He also did a lot of work to develop Chinese mathematics. It can be said that Professor yang is one of the mathematicians who made main influences on the mathematical development in modern China. This paper briefly introduces Professor yang's life, mainly discusses his academic achievement and influence, and briefly describes his contributions to the Chinese mathematics community.

关键词： Lo yang value distribution theory contribution

Effectiveness of nourishing Yin and tonifying yang sequential therapy in combination with Climen on diminished ovarian reserve: a retrospective study

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Journal of Traditional Chinese Medicine 2020年第1期40卷 150-156页

作者： Sun Yuying Tan Yong Chen Shuping Department of Reproductive Medicine The First Clinical Medical CollegeNanjing University of Traditional Chinese MedicineNanjingJiangsu 210029China Department of Gynecology Changzhou Hospital of Traditional Chinese MedicineChangzhouJiangsu 213003China

OBJECTIVE:To evaluate the clinical efficacy of nourishing Yin and tonifying yang sequential therapy(NYTYST)in combination with the Western Medicine Climen in treating diminished ovarian reserve(DOR).METHODS:From September 2014 to September2016,46 patients with DOR who received NYTYST and Climen(treatment group)and 51 patients who received Climen only(control group)at the Jiangsu Provincial Traditional Chinese Medicine Hospital(Nanjing,China)were retrospectively *** and at 3 months after treatment,serum levels of follicle-stimulating hormone(FSH),FSH/luteinizing hormone(LH),estradiol(E2),and anti-Mullerian hormone(AMH),the antral follicle count(AFC),stromal peak systolic velocity(PSV),symptom scores,and the clinical effectiveness rate were measured and compared between the two ***:After treatment,serum levels of FSH,FSH/LH and E2,and symptom scores were significantly decreased compared with before treatment(all P<0.05)in the two *** levels,AFC,and PSV were significantly increased after treatment compared with before treatment in both groups(all P<0.05).Serum levels of FSH,FSH/LH,and E2 after treatment were significantly lower in the treatment group than in the control group(all P<0.05).However,AMH levels and the AFC were significantly higher after treatment in the treatment group than in the control group(both P<0.05).The clinical effectiveness rate was significantly higher in the treatment group than in the control group(87%vs 68.6%,P<0.05).CONCLUSION:NYTYST combined with Climen may be more effective in treating DOR than Climen alone.

关键词： Diminished Ovarian reserve Nourishing Yin Reinforcing yang Sequential therapy Estradiol valerate,cyproterone acetate drug combination Retrospective studies

Therapeutic effect of dog-day moxibustion on herbs in knee-joint osteoarthritis of yang deficiency and congealing cold type

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World Journal of Acupuncture-Moxibustion 2019年第3期29卷 190-193页

作者： Xiufeng GU Fei WANG Yanyan ZHANG College of Acupuncture and Orthopedics Hubei University of Chinese MedicineWuhan 430065China Wuhan Hospital of Traditional Chinese Medicine Wuhan 430061China

Objective:To compare the therapeutic effect difference among dog-day moxibustion on herbs,ordinary moxibution and routine western medication in treating knee-joint osteoarthritis of yang deficiency and congealing cold ***:A total of 90 patients with knee-joint osteoarthritis of yang deficiency and congealing cold type were divided into dog-day moxibustion group,ordinary moxibution group and western medication group according to the registration order,and there were 30 patients in each *** them,the patients in the dog-day moxibustion were given dog-day moxibustion on herbs method during the dog days of 2018(July 17 to August 25).Continuous treatment was applied on the first,second and third dog-day with 5 days for each dog-day,and once for a day,and there were totally 15 times of *** the same period,the patients in the ordinary moxibustion group was treated with the pure moxa stick moxibustion,and the point selection and treatment course were the same as the dog-day moxibustion *** in the same period,the patients in the western medication group were treated with routine western medication,and the patient took orally diclofenac sodium sustained-release capsules,with 100 mg each time,once a *** Visual Analog Scale(VAS),Western Ontario and McMaster University Arthritis Index(WOMAC),life quality score and clinical efficacy for the knee joint of the three groups before and after treatment were ***:After treatment,the effective rate of the dog-day moxibustion was 93.33%,the effective rate of the ordinary moxibustion group was 83.33%,and the effective rate of the western medication group was 53.33%.Compared with pre-treatment,the VAS scores and WOMAC scores of the patients with KOA in the three groups after treatment decreased,and the differences were statistically significant(all P<0.05).There were also statistically significant differences between the VAS score,total WOMAC score,pain score,joint stiffness score and joint fu

关键词： Dog-day Moxibustion Moxibustion on herbs Knee-joint osteoarthritis yang deficiency and congealing cold Controlled trial

Yin and yang, and the Hot and the Cold

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Frontiers of Philosophy in China 2016年第1期11卷 73-87页

作者： NIE Minli School of Philosophy Renmin University of China Beijing 100872 China

Yin and yang are important concepts in ancient Chinese philosophy. Western scholars have become more familiar with these two concepts recently, but for a long time almost no one considered comparing them with their own tradition such as the ancient Greek philosophy, and especially with the ideas of the Hot and the Cold in Presocratic philosophy. In this paper, I make an attempt to do exactly that, and especially make a detailed comparison between the thoughts of two ancient thinkers： Laozi and Anaximander. I discuss the thought of Y/n and yang in Laozi--who was the earliest philosopher making use of the concepts Y/n and yang--to express his cosmological thought in ancient Chinese philosophy. Comparatively, 1 discuss the ideas of the Hot and the Cold in Anaximander, the earlier among Presocratic philosophers referring to the Hot and the Cold as fundamental concepts used to establish his cosmological system. Through this comparison, I indicate that the similarity between ancient Chinese and Western traditions is far more significant than what people are used to imagining.

关键词： Yin yang the Hot the Cold Laozi Anaximander cosmology

Historical Imagination and Cultural Identity: Revisiting yang Mu's Poetics of History

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2019年第1期13卷 49-71页

作者： Songjian ZHANG School of Humanities Nanyang Technological UniversitySingapore 637332Singapore

This essay aims to examine one key dimension of yang Mu's literary writings, namely, his "poetics of history." From 1968 to 2011, yang Mu created approximately twenty-two poems on history at different stages of his Iife. This paper holds that, by invoking historical memory, yang Mu not only offers his critical response to the polemics on modern Chinese poetry in 1970s Taiwan but also brilliantly conceives of two specific approaches and modes, namely,"observing and presenting history" and "reenacting and re-interpreting history." This paper argues that the second approach and mode, e.g., yang Mu speaking through fictionalized and dramatized historical figures, should be viewed as yang's insight, as it powerfully displays the originality and depth of the poet's vision. In addition, as the focus of yang Mu's historical imagination shifts from Chinese mainland to Taiwan over the decades, his cultural identity undergoes a major transforma廿on;in a sense, this shift results from the rise of Taiwan's nativization movement in the age of globalization.

关键词： yang Mu poetry history cultural identity