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EXPERIMENTAL WORK AND RESEAROHThe Experimental Study of xue Guan tong (血管通)on Preventing Restenosis after Percutaneous Transluminal Angioplasty

引用

Chinese Journal of Integrative Medicine 1995年第4期1卷 284-287页

作者： Shi Da-zhuo (史大卓) Xu Feng-ning (徐凤芹) Li Li-zhi (李立志) Ma Xiacachang (马晓昌) Wang Xiao-fang (汪晓芳) and Chen Ke-ji (陈可冀)(Hi-yuan Hospital, China Academy of TCM, Beijing 100091 )Li Ping (李平) Mao Jie-ming(毛节明) Chen Ming-zhe (陈明哲)an Xi-yuan Hospital China Academy of TCM Beijing The Third Affiliated Hospital Beijing Medical University Beijing

The effect of xue guen tong (XGT) granule in preveriting restenosis of atherosclerotic iliacartery after percutaneous transluminal angioplasty (PTA) in rabbits was studied. Forty-two purebred NewZealand rabbits with their endothelium of iliac arteries denuded and fed with high cholesterol diet for sixweeks to form the model of atheresclerotic stenosis. After PTA, the high cholesterol diet was stopped imme-diately and they were divided into 3 groups randomly. the XGT group, the lovastatin group and the controlgroup. Arterial angiogreph and pathological observation were carried out 4 weeks after PTA. The resultesbewed that ( 1 ) The luminal diameter of artery was 1 . 82 0. 46mm in the XGT group, 0 . 96 0. 71mm in thelovastetin grcxjp and 0. 71 0 . 53mm in the control group. The former one was larger than the latter two sig-nificantly ( P< 0. 01 ) . (2) Thickness of intima of artery was 0 . 27 0 . 40mm in the XGT group, it was thinnerthan those in the other two groups (O. 43 0. 04mm in the lovastatin group arid 0. 48 0. 10mm in the controlgroup) . (3) In XGT group, the smooth muscle cells ( SMCs) contained fewer organelles. more muscular fibersand were well differentiated than in the other two groups. The conclusion was XGT has the preventive effecton past-PTA arterial restenosis in rabbits.

关键词： restenosis after percutaneous transluminal angioplasty xue guen tong

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