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The Molecular Mechanism of xinyi san for the Treatment of Senile Rhinitis Based on Network Pharmacology

Journal of Biosciences and Medicines 2022年第8期10卷 110-121页

作者： Jing Xing Lingdi Wang Department of Pharmacy Affiliated Hospital of Chengde Medical College Chengde China

Objective: To study the molecular mechanism of xinyi san for the treatment of senile rhinitis by applying network pharmacological analysis technology. Methods: The effective components and corresponding targets of xinyi san were collected by TCMSP. The targets of senile rhinitis were collected by the Genecards database. The potential target of xinyi san in the treatment of senile rhinitis was obtained by Venn analysis. Cytoscape 3.7.2 the software constructs the relationship network model of “disease-single drug-active ingredient-action target”. Protein protein interaction (PPI) network was constructed by using a string database. R4.1.1 software was used for GO function enrichment analysis and KEGG pathway enrichment analysis. Results: In this study, we obtained 158 active ingredients, 40 potential therapeutic targets, 74 GO projects, and 99 pathways. Major pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways of neurodegeneration-multiple diseases, etc. Conclusion: xinyi san has the characteristics of multi-component, multi-target, and multi-channel in the treatment of senile rhinitis. This study provides a basis for the in-depth study of xinyi san.

关键词： Network Pharmacology Senile Rhinitis xinyi san Molecular Mechanism

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Target Prediction of xinyi san for Rhinitis Based on Network Pharmacology

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Chinese Medicine 2022年第1期13卷 1-14页

作者： Lingdi Wang Ying Wang Yingxue Lin Xin Meng Department of Pharmacy The Affiliated Hospital of Chengde Medical College Chengde China

Objective: To analyze the potential mechanism of xinyi san in treating rhinitis through network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition and potential targets of xinyi san were got, and the target genes of rhinitis of xinyi san were extracted from GeneCards databases. Then we constructed protein-protein interactions (PPI) network of target genes, and then analyzed the Key genes in GO analysis and KEGG analysis. Results: We got 97 components, 53 potential therapeutic targets, 1009 GO items and 92 pathways in our study. The main pathways included Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, Human cytomegalovirus infection, Prostate cancer, etc. Conclusion: xinyi san plays a role in treating rhinitis through multiple components, multiple targets and multiple pathways.

关键词： Rhinitis Network Pharmacology xinyi san

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Target Prediction of xinyi san for Nasal Polyposis Based on Network Pharmacology

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Pharmacology & Pharmacy 2022年第2期13卷 69-80页

作者： Lingdi Wang Ying Wang Department of Pharmacy The Affiliated Hospital of Chengde Medical College Chengde China

Objective: To analyze the potential mechanism of xinyi san in treating nasal polyposis through network pharmacology. Methods: We Screened the active components and targets of xinyi san by TCMSP database, and disease targets through GeneCards database. We constructed “disease-single drug-component-target” network through software Cytoscape 3.7.2 and constructed PPI network through STRING database. GO function and KEGG pathway enrichment were analyzed to predict its mechanism. Results: We got 162 components, 69 therapeutic targets, 88 GO items and 135 pathways. The main pathways include Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, Kaposi sarcoma-associated herpesvirus infection, Hepatitis B, Human cytomegalovirus infection, etc. Conclusion: This study preliminarily revealed the active components, targets and pathways of xinyi san in treating nasal polyposis.

关键词： Nasal Polyposis Network Pharmacology xinyi san

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