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nfluence and mechanism of xindakang on cardiac functions of isolated frog heart

中国药理学与毒理学杂志 2021年第10期35卷 764-765页

作者： KONG Xiu-mei JIANG Yi HAN Yi-wei ZHAO Qin Engineering Research Center of Tibetan Medicine Testing Technology of Ministry of Education Tibetan Medicine Screening LaboratorySchool of MedicineTibet University for NationalitiesXianyang 712082China

OBJECTIVE To evaluate the effects of flavonoids from xindakang(Hippophae Fructus flavone)on myocardial systolic and diastolic functions of isolated frog hearts and explore the possible mechanism,and provide experimental basis for improving the effect and efficacy of xindakang on cardiac *** The isolated frog heart perfusion specimens were prepared by Yagi′s method,and the effects of different concentrations of xindakang on myocardial contractility(0.0125,0.025,0.05,0.1 and 0.2 g·L^(-1)),heart rate and cardiac output of isolated frog heart were ***,atropine and epinephrine were administered successively to analyze the effects of xindakang on cardiac systolic function of isolated frogs under the action of different drugs,and compared with *** effect of extracellular calcium ion concentration on the action of xindakang was studied by using low calcium concentration,high calcium concentration and normal Ren′s *** study the effect and possible mechanism of xindakang on cardiac systolic function of *** The concentration of xindakang in the range of 0.0125-0.1 g·L^(-1)could weaken the contractility of isolated frog heart and increase the concentration of *** inhibitory effect of xindakang on contractility of isolated frog heart was enhanced,and showed obvious dose-effect *** output was significantly decreased by xindakang(Pxindakang,and xindakang could not completely antagonize the contractile effect of *** could inhibit the isolated frog heart in low calcium concentration,high calcium concentration and normal Ren′s solution,and increased with the increase of extracellular calcium concentration(Pxindakang has inhibitory effect on isolated frog heart,which may be achieved by blocking the calcium channel on myocardial cell membrane and reducing the cal

关键词： Hippophae Fructus flavone xindakang isolated frog heart cardiac function

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