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Observation of viable alloskin vs xenoskin grafted onto subcutaneous tissue wounds after tangential excision in massive burns

引用

Burns & Trauma 2016年第2期4卷 134-143页

作者： Haibin Zuo Guodong Song Wen Shi Jun Jia Yonghu Zhang Department of Burns Jinan Central Hospital Affiliated to Shandong University105 Jiefang RoadJinanShandong 250013PR China

Background:Staged excision and grafting with viable cryopreserved alloskin or fresh pigskin at an early stage is a main strategy for wound management in massive *** is the gold standard of a biological temporary skin substitute,and the main drawback to its wider use is the limited number of *** this paper,we compare the use of fresh pigskins to cryopreserved alloskins as temporary skin substitutes on subcutaneous tissue wounds after tangential excision by observing the clinical performances of these grafts in cases of a massive ***:We selected six adult massive burn patients undergoing tangential excision and skin grafting on subcutaneous tissue wounds(TESGSTW)at our burn center from January 1,2003 to December 31,*** general clinical data and survival percentage of skins at postoperative weeks(POWs)1,2,and 3 were *** our clinical practice,we also observed the phenomenon that several viable cryopreserved alloskin or fresh pigskin grafts used as temporary coverage on subcutaneous tissue wounds had long-term survival after repeated *** macroscopic and histological results of one typical case were also ***:In this study,the first three TESGSTW operations were performed at 2–3,5–8,and 11–16 days *** operation areas were 30.3±7.9%total body surface area(TBSA),19.0±6.0%TBSA,and 12.0±1.7%TBSA,*** survival percentage of the cryopreserved alloskins or fresh pigskins at POWs 1,2,and 3 were 80.0±10.0%vs 75.7±5.3%(t=1.01,P=0.16),71.2±10.6%vs 66.4±6.2%(t=1.09,P=0.30),and 48.7±2.5%vs 35.0±7.0%(t=3.83,P=0.03),*** microscopic observation of the survival of alloskins or pigskins in one typical case showed rete ridges and a basilar membrane at the joint of the epidermis and dermis at an early stage;these structures disappeared with extended time ***:From the clinical observations,fresh pigskin and cryopreserved alloskins could be used with equal effectiveness a

关键词： Burn Skin grafting Alloskin xenoskin Subcutaneous tissue

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