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wumei pills attenuates 5-fluorouracil-induced intestinal mucositis through Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB pathway and microbiota regulation

引用

World Journal of Gastroenterology 2022年第32期28卷 4574-4599页

作者： Dong-Xue Lu Feng Liu Hua Wu Hai-Xia Liu Bing-Yu Chen Jing Yan Yin Lu Zhi-Guang Sun Department of Nutrition Acupuncture and Moxibustion and Massage College&Health Preservation and Rehabilitation CollegeNanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Orthopaedics Nanjing Pukou District Chinese Medicine HospitalNanjing 210000Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Geriatrics The First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 451150Henan ProvinceChina Key Laboratory for Metabolic Diseases in Chinese Medicine The First Clinical Medical CollegeNanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Key Pharmacology Laboratory of Jiangsu Province Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina The First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

BACKGROUND Radiotherapy and chemotherapy can kill tumor cells and improve the survival rate of cancer ***,they can also damage normal cells and cause serious intestinal toxicity,leading to gastrointestinal mucositis[1].Traditional Chinese medicine is effective in improving the side effects of *** pills(WMP)was originally documented in the Treatise on Exogenous Febrile *** has a significant effect on chronic diarrhea and other gastrointestinal diseases,but it is not clear whether it affects chemotherapy induced intestinal mucositis(CIM).AIM To explore the potential mechanism of WMP in the treatment of CIM through experimental *** We used an intraperitoneal injection of 5-fluorouracil(5-Fu)to establish a CIM mouse model and an oral gavage of WMP decoction(11325 and 22650 mg/kg)to evaluate the efficacy of WMP in *** evaluated the effect of WMP on CIM by observing the general conditions of the mice(body weight,food intake,spleen weight,diarrhea score,and hematoxylin and eosin stained tissues).The expression of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-1β,and myeloperoxidase(MPO),as well as the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-κB(TLR4/MyD88/NF-κB)signaling pathway proteins and tight junction proteins(zonula occludens-1,claudin-1,E-cadherin,and mucin-2)was ***,intestinal permeability,intestinal flora,and the levels of short-chain fatty acids(SCFA)were also *** WMP effectively improved the body weight,spleen weight,food intake,diarrhea score,and inflammatory status of the mice with intestinal mucositis,which preliminarily confirmed the efficacy of WMP in *** experiments showed that in addition to reducing the levels of TNF-α,IL-1β,IL-6,and MPO and inhibiting the expression of the TLR4/MyD88/NF-κB pathway proteins,WMP also repaired the integrity of the mucosal barrier of mice,regulated the intestinal flora,and increased the levels of S

关键词： wumei pills Gut flora Intestinal mucosal inflammation Mucosal barrier Short-chain fatty acids Intestinal permeability

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