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Light-activated nanoclusters with tunable ROS for wound infection treatment

Bioactive Materials 2024年第11期41卷 385-399页

作者： Xin Wang Jianing Ding Xiao Chen Sicheng Wang Zhiheng Chen Yuanyuan Chen Guowang Zhang Ji Liu Tingwang Shi Jian Song Shihao Sheng Guangchao Wang Jianguang Xu Jiacan Su Wei Zhang Xiaofeng Lian Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China Department of Orthopaedics Xinhua Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai200092China Institute of Translational Medicine Shanghai UniversityShanghai200444China Organoid Research Center Shanghai UniversityShanghai200444China Department of Orthopedics Trauma Shanghai Zhongye HospitalShanghai200941China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai200444China

Infected wounds pose a significant clinical challenge due to bacterial resistance, recurrent infections, and impaired healing. Reactive oxygen species (ROS)-based strategies have shown promise in eradicating bacterial infections. However, the excess ROS in the infection site after treatments may cause irreversible damage to healthy tissues. To address this issue, we developed bovine serum albumin-iridium oxide nanoclusters (BSA-IrOx NCs) which enable photo-regulated ROS generation and scavenging using near infrared (NIR) laser. Upon NIR laser irradiation, BSA-IrOx NCs exhibit enhanced photodynamic therapy, destroying biofilms and killing bacteria. When the NIR laser is off, the nanoclusters' antioxidant enzyme-like activities prevent inflammation and repair damaged tissue through ROS clearance. Transcriptomic and metabolomic analyses revealed that BSA-IrOx NCs inhibit bacterial nitric oxide synthase, blocking bacterial growth and biofilm formation. Furthermore, the nanoclusters repair impaired skin by strengthening cell junctions and reducing mitochondrial damage in a fibroblast model. In vivo studies using rat infected wound models confirmed the efficacy of BSA-IrOx NCs. This study presents a promising strategy for treating biofilm-induced infected wounds by regulating the ROS microenvironment, addressing the challenges associated with current ROS-based antibacterial approaches.

关键词： Infected wounds Iridium oxide Reactive oxygen species NIR laser wound restoration

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