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wound dressing products:A translational investigation from the bench to the market

Engineered Regeneration 2022年第2期3卷 182-200页

作者： Rossella Laurano Monica Boffito Gianluca Ciardelli Valeria Chiono Politecnico di Torino Mechanical and Aerospace Engineering DepartmentCorso Duca degli Abruzzi 2410129 TorinoItaly Centro 3R Interuniversity Center for the Promotion of 3Rs Principles in Teaching and ResearchPisaItaly

Chronic skin wounds affect more than 40 million patients globally and represent a severe growing burden for the healthcare systems,with annual costs expected to exceed$15 billions by *** satisfy the huge demand for effective wound care products,different types of wound dressings have been introduced on the market dur-ing the last *** on“the moist wound healing theory”postulated by Prof Winter in 1962,bandages were initially designed to recreate the optimal wound environment to favor the healing ***,thanks to the advancements achieved in biomaterial design and processing,biotechnology,imaging and electronic fields,great effort has been devoted to the development of formulations able to actively participate to tissue ***,both the literature and the market report the design of medicated wound dressings,i.e.,wound care products releasing anti-microbial agents,anti-inflammatory drugs,or bioactive *** this scenario,this review aims at critically describing the currently available wound care products,highlighting their proved effec-tiveness in wound ***,an overview of the main strategies exploited to design personalized wound dressings has been ***,concerns on regulatory affairs and practical issues limiting the clinical translation of advanced research platforms have also been discussed.

关键词： Hard-to-close wounds wound dressing effectiveness Medicated wound bandages Advanced wound care products Personalized medicine Regulatory affairs

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