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Application of chitosan-based nanoparticles in skin wound healing

Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 299-332页

作者： Hooi Leong Loo Bey Hing Goh Learn-Han Lee Lay Hong Chuah School of Pharmacy Monash University MalaysiaSelangor 47500Malaysia Biofunctional Molecule Exploratory Research Group School of PharmacyMonash University MalaysiaSelangor 47500Malaysia College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Novel Bacteria and Drug Discovery(NBDD)Research Group Microbiome and Bioresource Research StrengthJeffrey Cheah School of Medicine and Health SciencesMonash University MalaysiaSelangor 47500Malaysia

The rising prevalence of impaired wound healing and the consequential healthcare burdens have gained increased attention over recent *** has prompted research into the development of novel wound dressings with augmented wound healing ***(NP)-based delivery systems have become attractive candidates in constructing such wound dressings due to their various favourable *** non-toxicity,biocompatibility and bioactivity of chitosan(CS)-based NPs make them ideal candidates for wound *** review focusses on the application of CS-based NP systems for use in wound *** overview of the wound healing process was presented,followed by discussion on the properties and suitability of CS and its NPs in wound *** wound healing mechanisms exerted by CS-based NPs were then critically analysed and discussed in sections,namely haemostasis,infection prevention,inflammatory response,oxidative stress,angiogenesis,collagen deposition,and wound closure *** results of the studieswere thoroughly reviewed,and contradicting findings were identified and *** on the literature,the gap in research and future prospects in this research area were identified and *** evidence shows that CS-based NPs possess superior wound healing effects either used on their own,or as drug delivery vehicles to encapsulate wound healing *** is concluded that great opportunities and potentials exist surrounding the use of CSNPs in wound healing.

关键词： Biopolymer Chitosan nanoparticle Nanotechnology wound dressing wound healing

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