检索结果-南通市图书馆

A novel corneal adhesive based on functionally coupled PEG-lysozyme hydrogel for wound closure after surgical eye surgery

引用

Chinese Chemical Letters 2022年第9期33卷 4321-4325页

作者： Shaohua Zhang Hang Zhou Chang Huang Jianguo Sun Xue Qu Yi Lu Eye Institute and Department of Ophthalmology NHC Key Laboratory of Myopia(Fudan University)Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai Key Laboratory of Visual Impairment and RestorationEye&ENT HospitalFudan UniversityShanghai 200031China Key Laboratory for Ultrafine Materials of Ministry of Education School of Material Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

Corneal wound closure for surgical eye surgeries or accidents is typically performed to prevent pathogens from the sterile intraocular environment and avoid potential postoperative *** adhesives are increasingly employed for corneal wound closure with superior treatment efficiency and less adverse *** this study,we successfully develop a novel corneal adhesive based on functionally coupled PEG-lysozyme(PEG-LZ)hydrogels for wound closure after surgical eye ***-LZ hydrogels have plenty of micropores and gradually decreased pore size with increasing concentration from 10%,15%to 20%(w/v),in which PEG-LZ(15%)represents the suitable pH value,gelation time and elastic ***-LZ hydrogels have no in vitro cytotoxicity and excellent ex vivo wound closure effectiveness in porcine *** in vivo wound sealant in rabbit eyes by PEG-LZ hydrogels presents a superior therapeutic effect compared with the conventional methods of stromal hydration and suture,in terms of the wound closure percent,mean corneal thickness,percent of wound gaping,and the Descemet membrane ***-LZ hydrogels do not induce obvious histological pathology *** PEG-LZ corneal adhesive is considered as a tissue adhesive alternative for wound closure after surgical eye surgeries.

关键词： Corneal adhesive Hydrogel wound closure Polyethylene glycol(PEG) Lysozyme

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury

引用

Science China(Life Sciences) 2017年第2期60卷 158-167页

作者： Hu Lei Yue Wang Tian Zhang Leilei Chang Yelin Wu Yuping Lai Shanghai Key Laboratory of Regulatory Biology School of Life Sciences East China Normal University Shanghai 200241 China

Human S100A7 (psoriasin) is highly expressed in psoriasis and other inflammatory diseases; however, the function of S100A7 in wound repair remains largely unknown. Here we demonstrated that skin injury increased the expression of S100A7. Damaged cells from wounded skin induced the expression of S100A7 via the activation of Toll-like receptor 3 (TLR3) followed by the activation of p38 MAPK. S100A7, in turn, acted on keratinocytes to induce the expression of terminal differentiation marker gene loricrin through the activation of p38 MAPK and caspase-1. The differentiation of keratinocytes induced by S100A7 resulted in skin stratification, thus efficiently promoting wound closure. Taken together, our results demonstrate that the activation of TLR3 accelerates wound closure via the induction of S100A7 to induce keratinocyte differentiation. These findings also provide new insights into the development of different forms of treatment with skin wounds.

关键词： TLR3 S100A7 caspase-1 keratinocyte differentiation wound closure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Use of antibacterial sutures for skin closure in controlling surgical site infections: a systematic review of published randomized, controlled trials

引用

Gastroenterology Report 2013年第1期1卷 42-50页

作者： Muhammad S.Sajid L.Craciunas P.Sains K.K.Singh M.K.Baig Department of General&Laparoscopic Colorectal Surgery Worthing HospitalWorthingWest SussexBN112DHUK

Objective:The objective of this article is to systematically analyse the randomized,controlled trials that compare the use of antibacterial sutures(ABS)for skin closure in controlling surgical site ***:Randomized,controlled trials on surgical patients comparing the use of ABS for skin closure in controlling the surgical site infections were analysed systematically using RevMan^(■)and combined outcomes were expressed as odds ratios(OR)and standardized mean differences(SMD).Results:Seven randomized,controlled trials evaluating 1631 patients were retrieved from electronic *** were 760 patients in the ABS group and 871 patients in the simple suture *** was moderate heterogeneity among trials(Tau^(2)=0.12;chi^(2)=8.40,df=6[Pclosure in surgical patients was associated with a reduced risk of developing surgical site infections(OR,0.16;95%CI,0.37,0.99;z=2.02;Pclosure in patients undergoing various surgical ***:Use of ABS for skin closure in surgical patients is effective in reducing the risk of surgical site infection and postoperative *** is comparable with SS in terms of length of hospital stay and duration of operation.

关键词： wound closure surgical site infection antibacterial sutures operative complications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：