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Understanding normal and abnormal development of the wolffian/epididymal duct by using transgenic mice

Asian Journal of Andrology 2015年第5期17卷 749-755,I0007页

作者： Aki Murashima Bingfang Xu Barry T Hinton Department of Developmental Genetics Institute of Advanced Medicine Wakayama Medical University 811-1 Kimiidera Wakayama 641-8509 Wakayama Japan Department of Cell Biology University of Virginia School of Medicine Charlottesville VA 22908 USA

The development of the wolffian/epididymal duct is crucial for proper function and, therefore, male fertility. The development of the epididymis is complex; the initial stages form as a transient embryonic kidney; then the mesonephros is formed, which in turn undergoes extensive morphogenesis under the influence of androgens and growth factors. Thus, understanding of its full development requires a wide and multidisciplinary view. This review focuses on mouse models that display abnormalities of the wolffian duct and mesonephric development, the importance of these mouse models toward understanding male reproductive tract development, and how these models contribute to our understanding of clinical abnormalities in humans such as congenital anomalies of the kidney and urinary tract （CAKUT）.

关键词： epididymis mesonephros transgenic mice wolffian duct

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Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis

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Asian Journal of Andrology 2020年第4期22卷 342-347页

作者： Joanne Wong Almas R Juma Stephanie C Tran Jemma G Gasperoni Sylvia V H Grommen Bert De Groef Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVictoria 3086Australia

Mice deficient in the transcription factor pleomorphic adenoma gene 1(PLAG1)exhibit reproductive issues that are characterized,in part,by decreased progressive sperm motility in the ***,the underlying cause of this impairment is *** epididymal transit is critical for sperm maturation and motility,the morphology of the epididymis of Plag1-deficient mice was investigated and the spatial expression patterns of PLAG1 protein and mRNA were *** X-gal staining and in situ hybridization,PLAG1 was shown to be widely expressed in both the epithelium and stroma in all regions of the mouse ***,the X-gal staining pattern was markedly different in the cauda,where it could be suggestive of PLAG1 secretion into the epididymal *** all ages investigated,the morphology of epididymides from Plag1 knockout(KO)mice was aberrant;the tubule failed to elongate and coil,particularly in the corpus and cauda,and the cauda was malformed,lacking its usual bulbous ***,the epididymides from Plag1 KO mice were significantly reduced in size relative to body *** 20%of Plag1-deficient mice,the left testicle and epididymis were *** impaired morphogenesis of the epididymal tubule is likely to be a major contributing factor to the fertility problems observed in male Plag1-deficient *** results also establish PLAG1 as an important regulator of male reproduction,not only through its involvement in testicular sperm production,but also via its role in the development and function of the epididymis.

关键词： development epididymis pleomorphic adenoma gene 1 tubule coiling wolffian duct

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