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Effect of Doxorubicin on Histomorphology of Liver of wistar albino Rats

Journal of Pharmacy and Pharmacology 2016年第4期4卷 174-178页

作者： Deepak Chaudhary Saroj Khatiwada Surendra Kumar Sah Man Kumar Tamang Soumya Bhattacharya Chandra Bhushan Jha M.Sc. Human Anatomy Department of Anatomy Nobel Medical College Biratnagar Nepal MSc. Medical Biochemistry Department of Biochemistry Modern Technical College Lalitpur Nepal M Sc. Medical Biochemistry Department of Nutrition and Dietetics Central Campus of Technology Dharan Nepal MD Anatomy Department of Human Anatomy B P Koirala Institute of Health Sciences Dharan Nepal

Doxorubicin is associated with adverse effects on organs like liver. This study was done to find the effects of doxorubicin on liver of wistar albino rats. Sixty healthy wistar albino rats were taken for the study. The rats were randomly divided in to 4 groups （2 experimental groups; group AI and A2, and 2 control groups;group Bland B2 each containing 16 rats）. The experimental groups were given a single dose of doxorubicin i.e. 10 mg/kg body weight intraperitoneally and sacrificed after 7 days and 14 days for each group. Rats under control groups were given a single intraperitoneal dose of 2.5 ml/kg body weight normal saline and sacrificed with their respective experimental groups. A significant difference （p 〈 0.001） and （p = 0.005） in final body weight was observed among group A1 experimental and BI control rats, and among group A2 experimental and B2 control rats. As compared to group B2 control, group A2 experimental rats had significantly （p = 0.043） lower liver weight. Diameter ofhepatocyte （p 〈 0.001 for both groups） and nucleus （p=0.004 for group A1 and control BI, and p 〈 0.001 for group A2 and control B2） was significantly higher in experimental rats as compared to their respective controls. Cross-sections of the liver of both control groups had normal architecture. However, there was progressive destruction of liver architecture across the experimental groups. Doxorubicin causes the disruption of normal architecture of liver in rats. Thus care needs to be taken during doxorubicin chemotherapy to minimize effects on river.

关键词： Doxorubicin Histomorphometry Liver wistar albino rot.

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