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Association between Long Interspersed Nuclear Element-1 Methylation and Relative Telomere Length in wilms tumor

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Chinese Medical Journal 2015年第22期128卷 3055-3061页

作者： Hui-Bo Chang Ji-Zhen Zou Cai He Rui Zeng Yuan-Yuan Li Fei-Fei Ma Zhuo Liu Hui Ye Jian-Xin Wu Department of Biochemistry Capital institute of Pediatrics Beijing 100020 China Department of Pathology Capital institute of Pediatrics Beijing 100020 China Department of Surgery Capital institute of Pediatrics Beijing 100020 China

Background： DNA hypomethylation of long interspersed nuclear elements- 1 （LINEs- 1 ） occurs during carcinogenesis, whereas intbmaation addressing LINE-1 methylation in wilms tumor （WT） is limited. The main purpose of our study was to quantity, LINE-1 methylation levels and evaluate their relationship with relative telomere length （TL） in WT. Methods： We investigated LINE-1 methylation and relative TL using bisulfite-polymerase chain reaction （PCR） pyrosequencing and quantitative PCR, respectively, in 20 WT tissues, 10 normal kidney tissues and a WT cell line. Significant changes were analyzed by t-tests. Results： LINE-1 methylation levels were significantly lower （P 〈 0.05） and relative TLs were sigmificantly shorter （P 〈 0.05） in WT compared with normal kidney. There was a significant positive relationship between LINE- 1 methylation and relative TL in WT （r = 0.671, P = 0.001 ）. LINE- 1 Methylation levels were significantly associated with global DNA methylation （r = 0.332, P 〈 0.01 ）. In addition, relative TL was shortened and LINE- 1 methylation was decreased in a WT cell line treated with the hypomethylating agent 5-aza-2＇-deoxycytidine compared with untreated WT cell line. Conclusion： These results suggest that LINE-1 hypomethylation is common and may be linked to telomere shortening in WT.

关键词： 5-aza-2'-deoxycytidine Hypomethylation Long Interspersed Nuclear Element-1 Relative Telomere Length wilms tumor

Expression of vascular endothelial growth factor （VEGF） and VEGF-C in serum and tissue of wilms tumor

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Chinese Medical Journal 2011年第22期124卷 3716-3720页

作者： WANG Lei ZHANG Da CHEN Xin-rang FAN Yu-xia WANG Jia-xiang Department of Pediatric Surgery the First Affiliated Hospital Zhengzhou University Zhengzhou Henan 450052 China

Background Angiogenesis and lymphogenesis which were promoted by vascular endothelial growth factor （VEGF） and VEGF-C are important in the growth and metastasis of solid tumors. The high level of VEGF and VEGF-C were distributed in numerous types of cancers, but their distribution and expression in wilms tumor, the most common pediatric tumor of the kidney, was unclear. Methods To learn about the distribution, mass spectroscopy and immunohistochemistry were used to measure the level of VEGF and VEGF-C in serum and tissue of wilms tumor. Results The expression level of VEGF in serum of wilms tumor was the same as in pre-surgery and control, so it was the same case of VEGF-C. Both of these factors were chiefly located in wilms tumor tissue, but not in borderline and normal. In addition, the higher clinical staging and histopathologic grading were important elements in high expression of VEGF and VEGF-C. Gender, age and the size of tumor have not certainly been implicated in expression level of VEGF and VEGF-C. Conclusions The lymph node metastasis and growth of tumors resulted from angiogenesis and lymphogenesis which were promoted by VEGF and VEGF-C in wilms tumor. The autocrine and paracrine process of VEGF and VEGF-C were the principal contributor to specific tissues of wilms tumor but not to the entire body.

关键词： vascular endothelial growth factor vascular endothelial growth factor C wilms tumor

Prognostic Factors of wilms＇ tumor Complicated with Nephroblastomatosis

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Chinese Medical Journal 2015年第18期128卷 2539-2541页

作者： Hong-Chuan Niu Wei-Ping Zhang Ning Sun Le-Jian He Yun Peng Department of Pediatric Urology Beijing Children's Hospital Capital Medical University Beijing 100045 China Department of Pathology Beijing Children's Hospital Capital Medical University Beijing 100045 China Imaging Center Beijing Children's Hospital Capital Medical University Beijing 100045 China

Nephrogenic rests （NRs） are abnormally persistent clusters of embryonal cells, representing microscopic dysplasias of the developing kidney. NRs are found in approximately 1% of infant kidneys at autopsy. Nephroblastomatosis signifies the presence of multiple or diffuse NRs. Both NRs and nephroblastomatosis were known as precursor lesions of wilms tumor,Nephroblastomatosis can be classified into four categories： Perilobar （PEN R only）; i ntralobar （I LNR only）; combined （PLNR and ILNR）; and universal. The diagnosis and treatment of wilms＂ tumor have been improved constantly and achieved common sense. However, little information is available regarding wilms＂ tumor associated with nephroblastomatosis for lower prevalence. This study aimed to investigate the prognostic factors of wilms＇ tumor associated with nephroblastomatosis.

关键词： Multicentric Lesions Nephroblastomatosis Prognostic Factors wilms tumor

Loss of heterozygosity for chromosomes 16q in wilms tumors predicts outcomes:A meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2159-2167页

作者： Yuan-Hua Song Wen-Ling Li Zhen Yang Yan Gao Zhi-Ping Feng Department of Oncology Kunming Children's HospitalKunming 650103Yunnan ProvinceChina Department of Nuclear Medicine The Third Affiliated Hospital of Kunming Medical University(Yunnan Cancer Hospital)Kunming 650118Yunnan ProvinceChina

BACKGROUND The research findings suggest that the prognosis of children with wilms tumor(WT)is affected by various *** scholars have indicated that loss of heterozygosity(LOH)on chromosome 16q is associated with a poor prognosis in patients with *** To further elucidate this relationship,we conducted a *** This meta-analysis was registered in INPLASY(INPLASY2023100060).We systematically searched databases including Embase,PubMed,Web of Science,Cochrane,and Google Scholar up to May 31,2020,for randomized trials reporting any intrapartum fetal surveillance *** meta-analysis was performed within a frequentist framework,and the quality and network inconsistency of trials were *** ratios and 95%CIs were calculated to report the relationship between event-free survival and 16q LOH in patients with *** Eleven cohort studies were included in this meta-analysis to estimate the relationship between event-free survival and 16q LOH in patients with WT(I^(2)=25%,P<0.001).As expected,16q LOH can serve as an effective predictor of eventfree survival in patients with WT(risk ratio=1.95,95%CI:1.52–2.49,P<0.001).CONCLUSION In pediatric patients with WT,there exists a partial correlation between 16q LOH and an unfavorable treatment *** detection of 16q chromosome LOH warrants increased attention to the patient’s prognosis.

关键词： Loss of heterozygosity wilms tumor Survival time Chromosomes 16q

Nephroblastoma: Radiological and Pathological Diagnosis of a Case with Liver Metastases

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Open Journal of Radiology 2016年第1期6卷 24-28页

作者： Kouamé Ngoran Doukouré Brahima Manewa Fotso Sorelle Gaimou Blé P Yessoufou Bakary Nafissath N’Goan-Domoua Anne-Marie Department of Radiology at the University Hospital of Yopougon Abidjan Ivory Coast Department of Pathology at the University Hospital of Cocody Abidjan Ivory Coast Department of Radiology at the University Hospital Sylvanus Olympio Lome Togo

Nephroblastoma is one of the most common causes of abdominal-pelvic mass in children. It still raises a diagnostic problem because of the wide variety of causes of abdominal-pelvic mass but also because of the delays in consultation in sub-Saharan black Africa and consequently the discovery of the mass at a very late and sometimes metastatic stage. Yet nephroblastoma is a very chemo-sensitive malignancy requiring diagnosis at an early stage;a procedure in which medical imaging is essential. We report the case of a large abdominal-pelvic mass in a three-year-old girl in whom the abdominal-pelvic CT allowed to diagnose nephroblastoma with liver metastases. Our objective is to demonstrate the contribution of computed tomography in the diagnosis of large abdominal-pelvic mass of the child and discuss other causes of abdominal-pelvic mass of the child.

关键词： wilms tumor Abdominal-Pelvic CT Abdominal-Pelvic Mass Nephroblastoma Child