检索结果-南通市图书馆

Closer look at white-coat hypertension

World Journal of Methodology 2014年第3期4卷 144-150页

作者： Nurver Turfaner Sipahioglu Fikret Sipahioglu Department of Internal Medicine Cerrahpasa Medical Faculty Istanbul University

This review aims to clarify novel concepts regarding the clinical and laboratory aspects of white-coat hypertension(WCHT). Recent studies on the clinical and biological implications of WCHT were compared with existing knowledge. Studies were included if the WCHT patients were defined according to the 2013 European Society of Hypertension guidelines, i.e., an office blood pressure(BP) of ≥ 140/90 mm Hg, a home BP of ≤ 135/85 mm Hg, and a mean 24-h ambulatory BP of ≤ 130/80 mm Hg. WCHT studies published since 2000 were selected, although a few studies performed before 2000 were used for comparative purposes. True WCHT was defined as normal ABPM and home BP readings, and partial WCHT was defined as an abnormality in one of these two readings. The reported prevalence of WCHT was 15%-45%. The incidence of WCHT tended to be higher in females and in non-smokers. Compared with normotensive(NT) patients, WCHT was associated with a higher left ventricular mass index, higher lipid levels, impaired fasting glucose, and decreased arterial compliance. The circadian rhythm in WCHT patients was more variable than in NT patient's, with a higher pulse pressure and non-dipping characteristics. Compared with sustained hypertension patients, WCHT patients have a better 10-year prognosis; compared with NT patients, WCHT patients have a similar stroke risk, but receivemore frequent drug treatment. There are conflicting results regarding WCHT and markers of endothelial damage, oxidative stress and inflammation, and the data imply that WCHT patients may have a worse prognosis. Nitric oxide levels are lower, and oxidative stress parameters are higher in WCHT patients than in NT patients, whereas the antioxidant capacity is lower in WCHT patients than in NT patients. Clinicians should be aware of the risk factors associated with WCHT and patients should be closely monitored especially to identify target organ damage and metabolic syndrome.

关键词： white-coat hypertension Ambulatory blood pressure Target organ damage Glucose dysregulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of the CLC-Kb T481S polymorphism with childhood hypertension

引用

Health 2010年第7期2卷 682-684页

作者： Rainer Büscher 不详

Essential hypertension is a difficult diagnosis in children and the gene of the renal-epithelial chloride channel ClC-Kb is potentially predisposing. In vitro studies have shown that a common ClC-Kb threonine481serine (T481S) polymorphism leads to enhanced chloride channel activity and may predispose for hypertension (HT). We therefore analysed children at risk for HT for the T481S polymorphism and associated genotype with blood pressure (BP) status. A total of 48 children with essential hypertension (mean age 14.4 ±2.7 years, 26 male;22 female;mean BP 143.4 ±7.5/88 ±5.8 mmHg) were compared with 78 children with white-coat HT (WCHT), who showed occasionally hypertensive BP values, which were not confirmed by ambulatory blood pressure monitoring (mean age 13.7 ±2.5 years, 49 male, 29 female;mean BP 122.4 ±4.3/68.2 ±3.5 mmHg). Other causes of HT were excluded. Allelic frequencies of hypertensive patients were not significantly different from those with WCHT (HT: A 0.84;T 0.16 vs. WCHT: A 0.85;T 0.15). However, the T-allele was observed more frequently in WCHT subjects with systolic and diastolic BP exceeding the 90th percentile (A 0.71;T 0.29, n = 34, p <0.05, considered as borderline hypertensive). The preliminary data suggest that children with WCHT carry the ClC-Kb T481S polymorphism more often and that this variant may predispose for development of arterial HT.

关键词： Essential Hypertension white-coat Hypertension Ambulatory Blood Pressure Monitoring (Abpm) Clc-Kb T481s Polymorphism Renal-Epithelial Chloride Channel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：