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Recombinant human erythropoietin for repair of white matter damage

Neural Regeneration Research 2011年第8期6卷 635-640页

作者： Wei Zhou Xiao Rong Li Tao Weineng Lu Guangzhou Women and Children Medical Center Department of Neonatology Guangzhou Children's Hospital Guangzhou 510120Guangdong Province China

Erythropoietin has been shown to exhibit neuroprotective effects in animal models. A neonatal rat model of hypoxic-ischemic white matter damage was established via bilateral carotid artery ligation in 4-day-old Sprague-Dawley rats. The rats were subsequently treated with recombinant human erythropoietin to observe pathological changes in the brain and long-term neurobehavioral functions before and after intervention. Results showed that the number of myelin basic protein-positive cells, which reflected myelin/oligodendrocyte damage, significantly increased, although the number of amyloid precursor protein-positive cells, which reflected axonaf injury, significantly decreased in periventricular white matter at 72 hours and 7 days following erythropoietin intervention. The number of glial fibrillary acidic protein-positive cells, indicating astrocytic damage, significantly decreased in periventricular white matter of erythropoietin-treated rats at 48 hours, 72 hours, 7 days and 26 days. Following erythropoietin intervention in the 30-day-old rats, head-turning time in the slope test was shortened and open-field test scores increased. These results suggested that erythropoietJn promoted repair of white matter damage, as well as improved neurobehavioral functions in a rat model of hypoxic-ischemic injury.

关键词： white matter injury erythropoietin neonatal rats neural behavior neuroprotection

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Piezo1 suppression reduces demyelination after intracerebral hemorrhage

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Neural Regeneration Research 2023年第8期18卷 1750-1756页

作者： Jie Qu Hang-Fan Zong Yi Shan Shan-Chun Zhang Wei-Ping Guan Yang Yang Heng-Li Zhao Department of Emergency The Sixth Medical Center of Chinese PLA General HospitalBeijingChina The Second Medical Center&National Clinical Research Center for Geriatric Diseases Chinese PLA General HospitalBeijingChina Department of Neurology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina Department of Neurosurgery and State Key Laboratory of Trauma Burn and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Piezo1 is a mechanically-gated calcium *** studies have shown that Piezo1,a mechanically-gated calcium channel,can attenuate both psychosineand lipopolysaccharide-induced *** oligodendrocyte damage and demyelination occur in intracerebral hemorrhage,in this study,we investigated the role of Piezo1 in intracerebral *** established a mouse model of cerebral hemorrhage by injecting autologous blood into the right basal ganglia and found that Piezo1 was largely expressed soon(within 48 hours)after intracerebral hemorrhage,primarily in *** injection of Dooku1 to inhibit Piezo1 resulted in marked alleviation of brain edema,myelin sheath loss,and degeneration in injured tissue,a substantial reduction in oligodendrocyte apoptosis,and a significant improvement in neurological *** addition,we found that Dooku1-mediated Piezo1 suppression reduced intracellular endoplasmic reticulum stress and cell apoptosis through the PERK-ATF4-CHOP and inositol-requiring enzyme 1 signaling *** findings suggest that Piezo1 is a potential therapeutic target for intracerebral hemorrhage,as its suppression reduces intracellular endoplasmic reticulum stress and cell apoptosis and protects the myelin sheath,thereby improving neuronal function after intracerebral hemorrhage.

关键词： apoptosis Ca^(2+)homeostasis endoplasmic reticulum stress intracerebral hemorrhage myelin basic protein myelin degradation oligodendrocyte Piezo1 stroke white matter injury

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