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Distribution of ^3H—nicotine in Rat Tissues Under the Influence of Simulated Microgravity

Biomedical and Environmental Sciences 1999年第2期12卷 103-109页

作者： PARIMAL CHOWDHURY MICHAEL E. SOULSBY AND JAMES N. PASLEY (Department of Physiology and Biophysics, University of Arkansas for Medical Scienses, Little Rock, Arkansas 72205, USA) Univeristy of Arkansas for Medical Sciences 美国

Rat tail suspension offers a useful model to reproduce physiologic responses to *** present study was conducted in the head-down-tilt(HDT) rat model to assess changes in metabolism of body tissues employing 3H-nicotine. Twelve male rats were used in the study. Half of the rats were tail suspended at 30°for two weeks on a 12/12 light/dark cycle. During this period,body weight, food and fluid intakes were measured. At term, animals were anesthetized and injected IV withe a solution contaming 4 microuries of micotine. After 90 min the animals were sacrificed, exsanguinated and tissues (brain,blood,trachea,salivary gland,lung,heart,esophagus,spleen, kidneys and testes) were harvested. The distribution of 3H-nicotine per gram of each tissue was determinded and ealeulated as percent of total injected radioactivity. Final body weights of suspended ammals were significantly (P weightlessness.

关键词： Gravitation Animals Male Nicotine Rats Rats, Sprague-Dawley Research Support, Non-U.S. Gov't Tissue Distribution Tritium weightlessness simulation

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Impact of 60 Days of 6° Head Down Bed Rest on Cardiopulmonary Function,and the Effects of Taikong Yangxin Prescription(太空养心方) as A Countermeasure

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Chinese Journal of Integrative Medicine 2014年第9期20卷 654-660页

作者：石宏志李勇枝唐志忠仲崇发范全春高建义刘军莲米涛赵爽李莹辉 State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center

Objective： To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6^° head down bed rest （HDBR）, and the effects of Taikong Yangxin Prescription （太空养心方, TYP） as a countermeasure. Methods： Fourteen healthy male volunteers were randomly divided into a control group and a Chinese medicine （CM） group （7 in each group） by a random digital table based on their body weight. Both groups underwent6^° HDBR for 60 days. Subjects in the CM group received daily TYP pills and subjects in the control group received daily placebo pills. Cardiac systolic and pumping functions were measured by echocardiography before HDBR; on days 20, 42, and 57 of HDBR; and on day 3 of recovery after HDBR （R＋3）. Cardiopulmonary functional reserve and exercise capacity were evaluated before HDBR, on day 29, and on day R＋3 by exercise testing. Results： The heart rate （HR） increased gradually during HDBR. The HR was significantly higher on day 57 than before HDBR in the control group （P〈0.05）, but did not increase significantly in the CM group. The stroke volume/stroke volume index, ejection fraction, and left ventricular fractional shortening tended to decrease over time in the control group, but not in the CM group. These parameters were significantly higher in the CM group than in the control group on day 42 （P〈0.05 or P〈0.01）. Exercise testing showed that maximum 02 consumption （VO2max）, metabolic equivalents, relative 02 consumption （VO2）, 02 pulse, and exercise duration were significantly lower on day 29 than before HDBR in the control group, but not in the CM group. Conclusions： Sixty days of 6^° HDBR induced a reduction in cardiac systolic and pumping functions, and reduced cardiopulmonary functional reserve and exercise capacity. Administration of TYP significantly improved cardiac systolic and pumping functions, and maintained cardiopulmonary functional reserve and exercise capacity.

关键词： 6^°head down bed rest weightlessness simulation cardiopulmonary function Taikong Yangxin Prescription

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Dynamic effects of tail-suspension and NOS inhibitor on the pulmonary circulation of isolated lung in rats

Dynamic effects of tail-suspension and NOS inhibitor on the ...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： De-Sheng WANG,Cheng TAN,Hui-Juan WANG,Zhi-Li LI,Ming YUAN,Guo-Hua TANG,Hui-Ming LIU,Wen-Juan CHEN China Astronaut Research and Training Center,Beijing 100094,China

Objective:To study dynamic effects of simulated weightlessness and NOS inhibitor with tail-suspension (TS) on the pulmonary circulation of isolated lung perfusion in rats,so that to gather data for researches on mechanism of local regulation of pulmonary circulation and mechanism of orthostatic intolerance and the decrease of exercise ***:-30°tail-suspended rats were used as the model to simulate the physiological effects of *** rats were randomly arranged into control group(CON),7-day TS group(TS7) and TS14 *** the isolated lung perfusion technique in artificial thorax,the pulmonary arterial volume controlled by the Transonic Systems and the constant peristaltic pump at 13.58 mL/*** pressure of pulmonary arteries,veins and resistance were measured with a PowerLab/4SP physiological system,and done the effects of NOS ***:The maximal pulmonary arterial pressure,the resistance of pulmonary arteries and pulmonary circulation decreased significantly in the TS7 and TS14 *** 10 mol/L L-NAME could ameliorate these changes of the pulmonary ***:NOS inhibitors may have a good foreground in alleviating the orthostatic intorlarance and the decrease of exercise capability.

关键词： weightlessness simulation rat isolated lung perfusion pulmonary circulation resistance NOS inhibitor

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Changes of Stress-Strain Relationship of Rabbit Femoral Vein after Simulated weightlessness

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Journal of Nanjing Medical University 2003年第5期17卷 223-230,248,F003页

作者：岳勇姚永杰孙喜庆吴兴裕朱庆生 DepartmentofOrthopedics the210thHospitalofPLADalian116021 DepartmentofAerospaceMedicine DepartmentofOrthopedics XijingHospitalFourthMilitaryMedicalUniversityXi’an710032，P.R.China

Objective: To observe the effect of simulated weightlessness on stress-strain relationship and the structural change of rabbit femoral vein. Methods: After seting up the Head-Down Tilt (-20°) (HDT) model to simulate weightlessness, 24 healthy male New-Zealand Rabbits were randomly divided into HDT-21d group, HDT-10d group and control group, with 8 in each. Femoral venous strips and rings were used to make uniaxial tensile test of the longitudinal and circumferential specimens of the vessels. At last we observed the microstructure of femoral vein wall in 3 groups. Results : With the increasing of load stress, both longitudinal and circumferential strains of vein samples from 3 groups increased significantly (Pweightlessness-simulation and increased much obviously after 21d-HDT than that of 10 d. The structure of femoral vein wall changed obviously. The changes may be one reason for the increase of femoral vein compliance.

关键词： weightlessness simulation compliance femoral vein stress-strain mi-crostructure tensile test

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