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Influence of weight management on the prognosis of steatohepatitis in chronic hepatitis B patients during antiviral treatment

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 416-425页

作者： Xiu-Juan Chang Yi-Wen Shi Jing Wang Hua-Bao Liu Yan Chen Xiao-Ning Zhu Yong-Ping Chen Zu-Jiang Yu Qing-Hua Shang Lin Tan Qin Li Li Jiang Guang-Ming Xiao Liang Chen Wei Lu Xiao-Yu Hu Qing-Hua Long Lin-Jing An Zi-Yuan Zou Vincent Wai-Sun Wong Yong-Ping Yang Jian-Gao Fan Department of Liver Disease Chinese PLA General Hospitalthe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Liver Disease Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 610072China Department of Liver Diseases Traditional Chinese Medicine Hospital of ChongqingChongqing 400038China Department of Infectious and Liver Diseases Liver Research Centerthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Infectious Disease the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Center of Therapeutic Liver Disease the 960th Hospital of Chinese PLATaian 271000China Liver Disease Department Fuyang 2nd People's HospitalFuyang 236015China Department of Liver Diseases Fuzhou Infectious Diseases HospitalFuzhou 350025China Department of Infectious Diseases Southwest HospitalArmy Military Medical UniversityChongqing 400038China Department of Infectious Diseases Guangzhou 8th People’s HospitalGuangzhou 510060China Department of Hepatic Diseases Shanghai Public Health Clinical CenterShanghai 201508China Department of Liver Diseases Tianjin Second People’s HospitalTianjin Institute of HepatologyTianjin 300192China National Integrative Medicine Clinical Base for Infectious Diseases and Department of Infectious Diseases Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China Department of Infection and Liver Disease Yichun People’s HospitalYichun 336028China Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Background:Although concomitant nonalcoholic steatohepatitis(NASH)is common in chronic hepatitis B(CHB),the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain unclear.We aimed to investigate the outcomes of NASH in CHB patients receiving antiviral treatment.Methods:In the post-hoc analysis of a multicenter trial,na?ve CHB patients receiving 72-week entecavir treatment were enrolled.We evaluated the biochemical,viral and histopathological responses of these patients.The histopathological features of NASH were also evaluated,using paired liver biopsies at baseline and week 72.Results:A total of 1000 CHB patients were finally enrolled for analysis,with 18.2%of whom fulfilling the criteria of NASH.A total of 727 patients completed entecavir antiviral treatment and received the second biopsy.Serum HBe Ag loss,HBe Ag seroconversion and HBV-DNA undetectable rates were similar between patients with or without NASH(P>0.05).Among patients with NASH,the hepatic steatosis,ballooning,lobular inflammation scores and fibrosis stages all improved during follow-up(all Pweight gain(OR:0.187;95%CI:0.050-0.693;P=0.026)were less likely to have NASH resolution.Among patients without NASH at baseline,22(3.7%)developed NASH.Baseline BMI≥23 kg/m2(OR:12.506;95%CI:2.813-55.606;P=0.001)and weight gain(OR:5.126;95%CI:1.674-15.694;P=0.005)were predictors of incident NASH.Conclusions:Lower BMI and weight reduction but not virologic factors determine NASH resolution in CHB.The value of weight management in CHB patients during antiviral treatment deserves further evaluation.

关键词： Nonalcoholic steatohepatitis Hepatitis B NASH resolution Antiviral treatment weight management

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weight management of Young Women with Down Syndrome: <i>C-ICAN</i>Meal Plan

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Case Reports in Clinical Medicine 2021年第11期10卷 393-402页

作者： JuliSu DiMucci-Ward Stephan L. Brown Department of Cell Biology and Physiology Edward Via College of Osteopathic Medicine Spartanburg SC USA

Primary care physicians are in a unique position to provide a holistic and individualized care to their patients with Down Syndrome. These patients share common medical problems with general population;however, they often are medically complex and present with cardiac, orthopedic, and endocrine challenges such as overweight-obesity and related comorbidities that occur with more frequency in this unique population. The prevention of overweight-obesity is an important public health issue for both the general population and for the population of individuals with Down Syndrome. If abnormal weight gain is treated early and effectively many secondary comorbidities can be prevented or ameliorated. This case report discusses the impact of implementing a Consistent Individualized Carbohydrate controlled Anti-inflammatory Nutrition plan (C-ICAN) as part of the treatment plan for a young woman with Down Syndrome (DS). The C-ICAN meal plan is a low glycemic load meal plan with 30% to 35% calories from fat, 20% to 25% calories from protein, 40% to 45% calories from carbohydrate, and goal of 25 gm fiber per day. The C-ICAN meal plan combines the Mediterranean diet because of its well-established anti-inflammatory, and cardiovascular benefits, with a high protein and low glycemic-load meal plan to improve satiety and glycemic control. In this case the patient and her caregivers adjusted to a structured meal pattern well, weight balance resulted, and mealtime stress was reduced.

关键词： Down Syndrome Obesity weight management C-ICAN Glycemic Load

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A Pilot Clinical Trial on L-Carnitine Supplementation in Combination with Motivation Training: Effects on weight management in Healthy Volunteers

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Food and Nutrition Sciences 2013年第2期4卷 222-231页

作者： Satoshi Odo Koji Tanabe Masamitsu Yamauchi Lonza Japan Ltd. TokyoJapan Department of Home Economics Registered Dietitians SectionAichi Gakusen UniversityOka-zakiJapan

A 4-week low dosage (500 mg/day) L-carnitine supplementation in combination with motivation training was carried out in 24 overweight (BMI 25.8 - 26.6 kg/m2) Japanese males in the course of a double-blind randomized placebo-controlled study. L-carnitine motivated group showed significant body weight loss and a decrement of serum triglyceride level vs. the non-motivated placebo group. Serum adiponectin levels increased in both L-carnitine supplemented groups. The beneficial effects of L-carnitine were amplified by motivation training. For clinical evaluation of supplements, whose efficacy is potentially affected by inter-individual life style variability, supportive motivation training might be advisable for future clinical trials.

关键词： L-Carnitine weight management Motivation Training Carnipure^(TM)

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The Danger within:Covid-19 Affinity for ACE2 Receptors in Adipose Tissue and Testes.The Protective Effects of Estradiol,Fitness,and weight management

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Journal of Endocrinology Research 2020年第1期2卷 1-14页

作者： Xanya Sofra City University LondonNew School for Social ResearchNew YorkUnited States

The imminent danger of the Covid-19 pandemic has accelerated research in pharmaceuticals that either target the viral Spike proteins fusion with ACE2 receptors,or the infectious RNA replication that often overwhelms immune defences.The scope of this review was to elucidate the main human vulnerabilities to Covid-19,including the accumulation of ACE2 receptors in testes,adipose tissue,thyroid,heart and kidneys that escalate viral affinity in males,the aged,and certain medical conditions,including diabetes,CVD,and pulmonary diseases.Pre-existing inflammation inherent in obesity may exacerbate the“cytokine storm,”a rampaging immune reaction during the course of Covid-19 that is deleterious to the host.We examined the molecular dynamics illustrating the action of new therapeutics necessary for Covid-19 patients;the estradiol advantage hypothesis;alternative therapies including hormone replacement procedures and mesenchymal stem cells;plus preventive and protective interventions.The current perspective also explored the primary components of dysregulated health predisposing individuals to Covid-19,including hormonal imbalance,increased lipids and lipoproteins,thyroid dysfunction,degraded fitness,and age-related testosterone decline accompanied by cortisol increase that provokes stress eating behaviours and weight accumulation.Obesity increases the probability of Covid-19 infection due to its abundance of ACE2 receptors;while physical activity may decrease Covid-19 vulnerability,by reducing fat and increasing muscle mass that manifests a relatively inhibited ACE2 expression.Several weight management solutions feature lasers and radiofrequency which diminish subcutaneous adiposity but do not enhance fitness.A data metanalysis of seven recently published clinical studies on 95 obese individuals,73 males and 22 females with an average BMI of 30.9,demonstrated visceral fat reduction combined with increased skeletal muscle mass.It also revealed a statistically significant decrease in BMI,lipids,lipoproteins,inflammation and

关键词： Visceral Adipose Tissue ACE2 Testes Covid-19 Estradiol Fitness weight management Leptin Free T3 Testosterone BMI BMR VLDL Triglycerides HDL Creatinine Bilirubin Ghrelin Insulin IGF-1 Cortisol CRP Diabetes Prediabetes Hyperphagia

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The Effectiveness of Implementing Dietary Interventions on weight management for the Elderly in A Senior Care Center

The Effectiveness of Implementing Dietary Interventions on W...

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中国营养学会第十五届全国营养科学大会

作者： Shuyi Zhou Hagedorn University of Texas Arlington School of Social Work

Being an unhealthy weight is associated with health risks for older adults. Research has suggested that obesity is associated with an increased risk of many chronic diseases and mortality, while being underweight is linked to elevated mortality risk. A proper and timely nutrition intervention could be helpful for seniors to maintain a healthy weight. However, few studies have explored the effectiveness of nutrition interventions on weight management in senior care centers in China. This study aims to investigate the effectiveness of implementing nutrition interventions on weight management for the elderly in a senior care center. Methods Participants were recruited from residents who stayed in a senior care center in Xiamen City, Fujian Province from October 2020 to December 2021. Participants who left or lived in the senior care center for less than one month, who could not be weighed due to medical conditions, or had missing data were excluded. Detailed information on medical history, observations from a physical examination report, height, and weight were obtained at baseline. A registered dietitian provided nutritional screening(assessed by the Malnutrition Universal Screening Tool), nutritional assessment(determined by the Nutrition-Focused Physical Exam), dietary diaries analysis(based on 7-day food dietary diaries), personalized nutritional interventions for participants, and follow-up regularly or as needed. The registered dietitian also provided nutrition education classes once a month. In addition, the registered dietitian designed the aging-friendly and nutritionally-balanced menu according to the Chinese Dietary Guidelines for the Elderly(2016 Version). Participants were weighed once a month by trained staff. The BMI levels and weight changes of participants were calculated and analyzed by the registered dietitian. The registered dietitian would conduct a timely nutrition intervention if a participant was found to have significant weight change. Categorizations based on BMI<18.5 kg/m2, 18.5≤BMI<24 kg/

关键词： nutrition intervention weight management nutrition status older adults senior care center China

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Less Aggressive weight Making Practices in Combat Sport When Recovery Time is Limited:weight Loss Practices of Pencak Silat Athletes in Singapore

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Journal of Science in Sport and Exercise 2022年第1期4卷 60-65页

作者： Cheryl Jia Hui Teo Shakir Juanda Reid Reale Sport Nutrition Team Singapore Sport InstituteSport Singapore3 Stadium DriveSingapore 397630Singapore High Performance and Athlete Life Singapore Sport InstituteSport SingaporeSingapore 397630Singapore UFC Performance Institute ShanghaiChina

Abstract weight making behaviours and best practice recommendations for various combat sports have been well documented,how-ever this is not true for Silat athletes.Pre-and post-weigh-in recommendations for other combat sports may not be suitable for Silat due to differences in weigh-in rules.Using a well-established questionnaire,this questionnaire-based cross sectional study examined weight making practices of Silat match athletes(n=102)competing at a national Pencak Silat championship.The 24.5%of athletes engaged in pre-competition weight loss,and the overall Rapid weight Loss Score(RWLS)was 27.7±8.7,considerably lower than other combat sports.The median age when weight loss began was 17 years,with 32%(n=8)starting such practices under 17 years.Risky weight management practices such as the use of laxatives,diet pills and vomiting were less common than in other combat sports.Coaches and fellow athletes are key influencers of weight making practices,and dietitians were found be an underutilised resource.Appropriate measures to empower coaches and athletes with the knowledge and ability to guide and execute less detrimental weight making practice with the involvement of dietitians are suggested.The study findings provide information to establish Silat-specific dietary strategies to improve health and performance.

关键词： Nutrition Behaviour Combat sport Questionnaire weight management

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Effects of novel vaccines on weight loss in diet-induced-obese(DIO) mice

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Journal of Animal Science and Biotechnology 2012年第3期3卷 136-142页

作者： Keith N Haffer Braasch Biotech LLC 421 Rose AvenueGarrestonSD 570303-0430USA

The purpose of the study was to test the therapeutic effects of novel vaccines for reducing weight gain and increasing weight loss in diet induced obesity （DIO） model. Male C57BL/6 J mice, fed a 60% Kcal fat diet for 8 weeks prior to the start of the study, were vaccinated via the intraperitoneal route with two formulations （JH17 ＆ JH]8） of chimeric-somatostatin vaccines at 1 and 22 days of the study. Control mice were injected with PBS. All mice continued to be feed the 60% Kcal fat diet for the week and food intake was measured weekly. At week 6 6 week study. Body weights were measured two times a mice were euthanized and a terminal bleed was made and antibody levels to somatostatin and levels of insulin-like growth factor 1 （IGF-1） were determined. Vaccination with both vaccine formulations induced a statistically significant body weight change over the study period, as compared with PBS controls. Percentage of baseline body weight was also significantly affected by vaccination during the study period. Vaccinates finished the study at 104% and 107% of baseline weight, JHI7 ＆ JH18 respectively, while untreated controls reached 115% of baseline weight. Food intake per mouse was similar in all mouse groups during the entire study. Control mice did not demonstrate any antibody titers to somatostatin, while all vaccinated mice had measurable antibody responses （〉 1：500,000 titer）. IGF-1 levels were not statistically significant among the groups, but were elevated in the JH18 vaccinates （mean 440.4 ng/mL） when compared with PBS controls （mean 365.6 ng/mL）. Vaccination with either JH17 or JH18 chimeric -somatostatin vaccines produced a statistically significant weight loss as compared with PBS controls （P 〈 0.0001）, even though the DIO mice with continually fed a 60% Kcal fat diet. The weight loss/lower weight gain observations were even more significant, as all mice consumed similar amounts of food for the entire study. The presence of high levels of anti-somatostatin antibodies at 6 weeks was correlative with the w

关键词： Obesity Treatment Vaccines weight loss weight management

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