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Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains unexplored.AIM To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer.METHODS The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work group.This pilot study sought to analyze the association between weight loss and inflammatory status as defined by SIRI.The cohort stems from a proof-of-concept pilot study conducted at one of the coordinating centers.Patients with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were included.The index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation chemotherapy.This study evaluated associations between overall survival(OS),SIRI and weight loss.RESULTS A total of 50 patients were included.66%of these patients were male and the median age was 66 years.Metastasis sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple locations.Regarding the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI levels.This difference was statistically significant(P<0.000).For patients with a SIRI<2.3×10^(3)/L,those who did not

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index weight loss

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Liver decompensation after rapid weight loss from semaglutide in a patient with non-alcoholic steatohepatitis -associated cirrhosis

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World Journal of Gastroenterology 2023年第47期29卷 6165-6167页

作者： Matthew Peverelle Jonathan Ng James Peverelle Ryan D.Hirsch Adam Testro Liver transplant unit Austin HealthMelbourne 3084Australia Liver transplant unit Austin HealthHeidelberg 3084VictoriaAustralia

There is rapidly increasing uptake of GLP-1 (glucagon-like peptide-1) agonistssuch as semaglutide worldwide for weight loss and management of non-alcoholicsteatohepatitis (NASH). remains a paucity of safety data in the vulnerable NASHcirrhotic population. We report herein the first documented case of liver decompensationand need for liver transplant waitlisting in a patient with NASHcirrhosistreated with semaglutide. Rapid weight loss led to the development ofascites and hepatic encephalopathy and an increase in the patients Model forEndstage Liver Disease-Na (MELD-Na) score from 11 to 22. Aggressive nutritionalsupplementation was commenced and the semaglutide was stopped. Overthe following months she regained her weight and her liver recompensated andher MELD-Na decreased to 13, allowing her to be delisted from the transplantwaitlist. This case serves as a cautionary tale to clinicians using semaglutide in thecirrhotic population and highlights the need for more safety data in this patientgroup.

关键词： Semaglutide Non-alcoholic steatohepatitis Cirrhosis Non-alcoholic steatohepatitis cirrhosis Glucagon-like peptide 1 agonists weight loss

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Novel subtype of obesity influencing the outcomes of sleeve gastrectomy:Familial aggregation of obesity

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World Journal of Gastroenterology 2024年第13期30卷 1887-1898页

作者： Ze-Yu Wang Yun-Fei Qu Tian-Ming Yu Zeng-Lin Liu Yu-Gang Cheng Ming-Wei Zhong San-Yuan Hu Department of General Surgery The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan HospitalJinan 250000Shandong ProvinceChina Department of Postgraduate Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250000Shandong ProvinceChina Department of General Surgery Shandong Provincial Qianfoshan HospitalCheeloo College of Medicine Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 276005Shandong ProvinceChina

BACKGROUND Differences in the preoperative characteristics and weight loss outcomes after sleeve gastrectomy(SG)between patients with familial aggregation of obesity(FAO)and patients with sporadic obesity(SO)have not been elucidated.AIM To explore the impact of SG on weight loss and the alleviation of obesity-related comorbidities in individuals with FAO.METHODS A total of 193 patients with obesity who underwent SG were selected.Patients with FAO/SO were matched 1:1 by propensity score matching and were categorized into 4 groups based on the number of first-degree relatives with obesity(1 SO vs 1FAO,2SO vs 2FAO).The baseline characteristics,weight loss outcomes,prevalence of obesity-related comorbidities and incidence of major surgeryrelated complications were compared between groups.RESULTS We defined FAO as the presence of two or more first-degree relatives with obesity.Patients with FAO did not initially show significant differences in baseline data,short-term postoperative weight loss,or obesity-related comorbidities when compared to patients with SO preoperatively.However,distinctions between the two groups became evident at the two-year mark,with statistically significant differences in both percentage of total weight loss(P=0.006)and percentage of excess weight loss(Pweight loss outcomes;the alleviation of T2DM,hyperlipidemia and NAFLD;and decreased incidence of acid reflux postoperatively.

关键词： Obesity Bariatric surgery Sleeve gastrectomy Family history weight loss

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Does weight loss affect the center of pressure of children with obesity: a follow-up study

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Journal of Leather Science and Engineering 2022年第1期4卷 121-129页

作者： Linshan Zhang Shiyang Yan Ruoyi Li Weihua Dan Luming Yang National Engineering Research Center of Clean Technology in Leather Indus-try ChengduChina Key Laboratory of Leather Chemistry and Engineering(Sichuan University) Ministry of EducationChengduChina

Background:Children with obesity were found to show the greater postural instability compared to the normal-weighted children.However,it’s still unclear if their altered postural control ability would recover towards normal pat-tern after weight loss.The purpose of this study was to investigate the effect of weight loss on the center of pressure(COP)for obese children.Method:Totally 147 children were conducted a follow-up study in three years.A total number of 22 participants aged 7-13 years were recruited for their remission of obesity problem after 36 months.Their dynamic plantar pressure data were collected by Footscan pressure plate.The normalized time of four sub-phases,displacements and velocities of COP in anterior-posterior(AP)and medial-lateral(ML)directions were calculated to perform the Kolmogorov-Smirnov test and paired sample t test for statistical analyses.Results:After weight loss,children’s normalized time of forefoot contact phase(FFCP)increased significantly,and their duration of flat foot phase(FFP)decreased significantly.They also exhibited the more medial and posterior ori-entated COP path after weight loss.In ML-direction,the COP displacement during FFP and FFPOP increased,and the COP velocity during FFPOP increased.In AP-direction,COP velocity during FFP and FFPOP increased.Conclusions:The findings indicated that weight loss would have effects on the COP characteristics and postural stability for obese children.COP trajectory can provide essential information for evaluating foot function.The findings may be useful for obese children,medical staff,and healthcare physician.

关键词： weight loss Obesity Children Center of pressure Postural stability

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weight loss and Improved Metabolic Health Measures Using a One-Week Active Nutrition Jumpstart Program in Overweight and Obese Men and Women

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Health 2023年第6期15卷 640-653页

作者： Richard J. Bloomer Jacquelyn Pence Allyson Davis Michelle Stockton Center for Nutraceutical and Dietary Supplement Research College of Health Sciences University of Memphis Memphis TN USA

Background: The prevalence of individuals who are obese or overweight is an increasing global epidemic that is associated with a multitude of adverse health conditions. Multiple strategies are available to promote weight loss in these populations, including the use of caloric restriction and/or liquid diets. We determined the impact of a low-calorie, nutrient-dense, primarily liquid diet on body weight and associated measures of metabolic health in overweight and obese men and women. Methods: Twenty-six men and women (age: 42.6 ± 10.8) completed a seven-day intervention using the USANA Active Nutrition Jumpstart program, which consisted of consuming three meal replacement shakes and three to four servings of fruits and vegetables, along with a probiotic, three metabolism supplements, and two vitamin packs each day. Pre-post measurements included body composition—determined (via DXA), fasting levels of lipids and glucose in heparinized whole blood, weight, waist circumference, hip circumference, heart rate, and blood pressure. Subjective mood and hunger were also assessed. Results: The dietary program was well-tolerated, and the intervention resulted in a mean weight loss of approximately 4.5 pounds. Clinically relevant reductions were noted in systolic and diastolic blood pressure, cholesterol (total and LDL), and glucose. In addition, there were favorable changes in self-esteem, energy, motivation, and physical appearance. Conclusion: A one-week period of adherence to the Active Nutrition Jumpstart program positively impacted subjective feelings, while resulting in significant weight loss and other health benefits that may have clinical relevance. Longer-term interventions are needed to sustain these initial results.

关键词： weight loss Supplement Fiber Caloric Restriction

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Exercise attenuates bone mineral density loss during diet-induced weight loss in adults with overweight and obesity:A systematic review and meta-analysis

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Journal of Sport and Health Science 2021年第5期10卷 550-559页

作者： Jakub Mesinovic Paul Jansons Ayse Zengin Barbora de Courten Alexander J.Rodriguez Robin M.Daly Peter R.Ebeling David Scott Department of Medicine School of Clinical Sciences at Monash HealthMonash UniversityClaytonVIA 3168Australia Institute for Physical Activity and Nutrition(IPAN) School of Exercise and Nutrition SciencesDeakin UniversityBurwoodVIA 2134Australia School of Medical and Health Sciences Edith Cowan UniversityPerthWA 6027Australia Department of Medicine and Australian Institute of Musculoskeletal Science Melbourne Medical SchoolWestern CampusUniversity of MelbourneSt AlbansVIA 3021Australia

Background:weight-loss-induced fat loss improves cardiometabolic health in individuals with overweight and obesity;however,weight loss can also result in bone loss and increased fracture risk.weight-loss-induced bone loss may be attenuated with exercise.Our aim was to compare changes in bone mineral density(BMD)in adults with overweight and obesity who undertook diet-induced weight loss alone or in combination with exercise.Methods:We included randomized controlled trials(RCTs)in adults with overweight or obesity(aged-18 years;body mass index-25 kg/m^(2))that prescribed diet-induced weight loss alone or in combination with supervised exercise,and measured any bone structural parameters.Risk of bias was assessed using the Cochrane Risk of Bias tool.Random-effects meta-analyses determined mean changes and net mean differences(95%confidence intervals(95%CIs))in the percentage of areal BMD(aBMD)change between groups.Results:We included 9 RCTs.Diet-induced weight loss led to significant losses in femoral neck aBMD(mean change:-1.73%(95%CI:-2.39%to-1.07%),plosses were significantly greater in the diet-induced weight loss group compared to the exercise plus diet-induced weight loss group(net difference:-0.88%(95%CI:-1.73%to-0.03%));however,there were no differences in aBMD changes at any other skeletal site:total hip(-1.96%(95%CI:-4.59%to 0.68%))and lumbar spine(-0.48%(95%CI:-1.81%to 0.86%)).aBMD changes did not differ significantly according to exercise modality(resistance exercise,aerobic exercise,or a combination of the two)during diet-induced weight loss.Conclusion:Diet-induced weight loss led to greater femoral neck bone loss compared to diet-induced weight loss plus exercise.Bone loss at the total hip and lumbar spine was not attenuated by exercise during diet-induced weight loss.The lack of consistent skeletal benefits may be due to the insufficient duration and/or training intensities of most exercise interventions.Additional RCTs

关键词： Bone mass Exercise Obesity Overweight weight loss

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Effects of novel vaccines on weight loss in diet-induced-obese(DIO) mice

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Journal of Animal Science and Biotechnology 2012年第3期3卷 136-142页

作者： Keith N Haffer Braasch Biotech LLC 421 Rose AvenueGarrestonSD 570303-0430USA

The purpose of the study was to test the therapeutic effects of novel vaccines for reducing weight gain and increasing weight loss in diet induced obesity （DIO） model. Male C57BL/6 J mice, fed a 60% Kcal fat diet for 8 weeks prior to the start of the study, were vaccinated via the intraperitoneal route with two formulations （JH17 ＆ JH]8） of chimeric-somatostatin vaccines at 1 and 22 days of the study. Control mice were injected with PBS. All mice continued to be feed the 60% Kcal fat diet for the week and food intake was measured weekly. At week 6 6 week study. Body weights were measured two times a mice were euthanized and a terminal bleed was made and antibody levels to somatostatin and levels of insulin-like growth factor 1 （IGF-1） were determined. Vaccination with both vaccine formulations induced a statistically significant body weight change over the study period, as compared with PBS controls. Percentage of baseline body weight was also significantly affected by vaccination during the study period. Vaccinates finished the study at 104% and 107% of baseline weight, JHI7 ＆ JH18 respectively, while untreated controls reached 115% of baseline weight. Food intake per mouse was similar in all mouse groups during the entire study. Control mice did not demonstrate any antibody titers to somatostatin, while all vaccinated mice had measurable antibody responses （〉 1：500,000 titer）. IGF-1 levels were not statistically significant among the groups, but were elevated in the JH18 vaccinates （mean 440.4 ng/mL） when compared with PBS controls （mean 365.6 ng/mL）. Vaccination with either JH17 or JH18 chimeric -somatostatin vaccines produced a statistically significant weight loss as compared with PBS controls （P 〈 0.0001）, even though the DIO mice with continually fed a 60% Kcal fat diet. The weight loss/lower weight gain observations were even more significant, as all mice consumed similar amounts of food for the entire study. The presence of high levels of anti-somatostatin antibodies at 6 weeks was correlative with the w

关键词： Obesity Treatment Vaccines weight loss weight management

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Bilateral common peroneal neuropathy due to rapid and marked weight loss after biliary surgery:A case report

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World Journal of Clinical Cases 2021年第8期9卷 1909-1915页

作者： Min Woo Oh Min Su Gu Hyun Ho Kong Department of Rehabilitation Medicine Chungbuk National University HospitalCheongju 28644South Korea

BACKGROUND The causes of peroneal neuropathy are various,but are rarely due to weight loss.Bilateral peroneal neuropathy caused by weight loss after surgery has been reported only after bariatric surgery and there were no reports associated with other abdominal surgery.In this report,we describe a case of the bilateral peroneal neuropathy that occurred due to marked weight loss after biliary surgery.CASE SUMMARY A 58-year-old male did not receive adequate nutritional support after biliary surgery,and showed a massive weight loss over a short period of time(body mass index;24.1 kg/m2 to 20.5 kg/m2 for 24 d).Then,foot drop occurred on both sides.Physical examination,electromyography(EMG)and magnetic resonance imaging studies were conducted and he was diagnosed as bilateral common peroneal neuropathy around the fibular head level.The patient was treated electrical stimulation therapy on both lower legs along with exercise therapy,and received sufficient oral nutritional support.The patient gradually recovered to his original weight,and the power of the dorsiflexor of bilateral ankles improved after conservative treatment.In addition,the follow-up EMG showed signs of improvement.CONCLUSION Any abdominal surgery that may have rapid and marked weight loss can lead to peroneal neuropathy as a complication.

关键词： Peroneal neuropathies weight loss Nutritional status General surgery Complication Case report

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Treatment of Nonalcoholic Fatty Liver Disease: The Role of Medical, Surgical, and Endoscopic weight loss

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Journal of Clinical and Translational Hepatology 2015年第3期3卷 230-238页

作者： Violeta B.Popov Joseph K.Lim Division of Gastroenterology New York University School of Medicine New York NY USA Yale Liver Center Section of Digestive Diseases Yale University School of Medicine New Haven CT USA

Nonalcoholic fatty liver disease (NAFLD) represents a rapidly growing cause of chronic liver disease in the United States and is associated with significant morbidity and mortality,including progression to liver cirrhosis and hepatocellular carcinoma.NAFLD comprises a spectrum of liver conditions,ranging from simple steatosis to steatosis with inflammation (steatohepatitis) and progressive fibrosis.weight loss represents a first line therapeutic modality for the management of NAFLD.Herein,we review the evidence base for medical,surgical,and endoscopic approaches to weight loss and their potential impact on the natural history of NAFLD.

关键词： Fatty liver Nonalcoholic steatohepatitis weight loss Exercise Pharmacotherapy Endoscopic therapy Bariatric surgery

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Apatite formation and weight loss study in EDMed perforated AZ31 Mg-alloy

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Journal of Magnesium and Alloys 2017年第3期5卷 362-367页

作者： Randeep Singh Gill Kamal Kumar Uma Batra Department of Mechanical Engineering PEC University of TechnologyChandigarh 160012India Department of Materials and Metallurgy Engineering PEC University of TechnologyChandigarh 160012India

Porous structures are highly preferred for bone regeneration and high tissue in-growth.In present work,electrical discharge drilling(EDD),a thermal erosion process was used to produce through holes in Mg-alloys to fabricate perforated structure similar to open cell porous structure in extruded AZ31.Apatite formation and weight loss study was conducted for 7 days,14 days and 21 days after immersion tests in SBF solution.The perforated structure in AZ31 with 26 through micro-holes provides 72%increase in surface area but with marginally 4%higher weight loss as compare to non-perforated structure.Comparing perforated and non-perforated samples of Mg-alloy,it was well observed that perforated structure forms high volume of apatite as compared to non-perforated structure.Scanning electron microscopic(SEM)study revealed that in perforated structure,drilled holes retain their circularity after 21 days of immersion test and distinct corrosion phenomenon occur at localized sites.

关键词： Mg-alloys AZ31 Perforated structure Electrical discharge drilling Apatite formation weight loss

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