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GC-MS and NMR analysis of the bioactive compounds from the crude extracts of Waltheria indica and the histopathological changes induced in albino rats challenged with Naja nigricollis venom

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Journal of Coastal Life Medicine 2016年第5期4卷 395-402页

作者： Philip Ilani Nicholas Ajodo Folashade Adewusi Samirat Yakubu Victor Yakubu Cosmos Ache Eunice Atonila Kayode Ezekiel Oshiedu Sarah Emmanuel Amlabu Department of Biochemistry Kogi State UniversityAnyigbaNigeria

Objective:To develop a characteristic fingerprint of the different chemical compounds of plant by gas chromatography-mass spectrometer(GC-MS)and nuclear magnetic resonance(NMR)analysis and assess the effect of the crude extract on histological changes induced in Naja nigricollis(***)envenomed albino ***:The coarsely powdered Waltheria indica(***)whole plant material was extracted using 70%***-MS analysis was carried out using a Shimadzu GC-MS QP 2010 plus system of gas chromatography interfaced to a mass *** identification of components was based on National Institute of Standard and Technology-08 and Willey-8 ***-NMR spectra of the extracts was performed using Bruker Biospin Avance 400-MHz NMR spectrophotometer with a 5 mm broad inverse probe head,equipped with shielded z-gradient accessories and C-13 NMR hetero-nuclear single quantum correction was carried out using the Brucker’s standard pulse *** efficacy of the crude extract of *** whole plant was tested and the lesions induced in the liver,brain and kidney of albino rats challenged with *** were analyzed by light ***:The identification of the bioactive compounds from *** by GC-MS analysis revealed 41 peaks.A total of 38 compounds were identified with majority having important pharmacological activities that included anti-microbial,anti-cancer,anti-oxidant antiinflammatory,anti-allergenic,anti-ageing,anti-arthritic,larvicidal,anti-convulsant and herbicidal activities.C-13 and hydrogen-NMR analysis of *** elucidated key bioactive compounds in the whole plant that were consistent with the classes of bioactive compounds detected by GC-MS *** efficacy of the crude extract of *** whole plant in ameliorating histopathological lesions induced in the liver,brain and kidney of albino rats challenged with *** venom revealed the abrogation of tissue degeneration when compared with the experim

关键词： Waltheria indica Gas chromatography-mass spectrometer Nuclear magnetic resonance Bioactive compounds Pharmacological activities web-based analysis Naja nigricollis venom Histopathology

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