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Medicinals with properties of warming yang and tonifying qi in terms of Traditional Chinese Medicine: their effects on left ventricular ejection fraction and aldosterone in rats with induced failure heart

引用

Journal of Traditional Chinese Medicine 2016年第6期36卷 789-793页

作者： Han Lihua Wang Zhentao Chai Songbo Xing Guohui Wang Hongxing Yuan Bin Li Zhiwei Su Shihao Department of Cardiology Traditional Chinese Medicine Hospital of Henan Province Department of Cardiology First Traditional Chinese Medicine Hospital of Luoyang

OBJECTIVE: To investigate on Left ventricular ejection fraction value and aldosterone of two medicinals of Traditional Chinese Medicine(TCM) with the properties of warming yang and tonifying qi in terms of TCM ***: An animal model of coronary ligation of heart failure after myocardial infarction was employed to study the influence of these two kinds of drugs on three batches of rats. On the basis of the average score of left ventricle ejection fraction during the investigation, there were some different groups, including Wen yang(the warming yang)group, Yi qi(tonifying qi) group, Wen yang and Yi qi group, captopril group, digoxin group. In additional, an artificial operation group was set for compari-son. The systemic intervention using these medicinal and drugs was taken effects on the 2nd day after the operation of myocardial infraction(MI) with once a day. At week one, two, and four after the MI treatment, evaluated were EF values, and ferritin,angiotensin-II and aldosterone in the rats' ***: At week one and week two, the medicinal of Wen yang, Yi qi, Wen yang pluse Yi qi, and digoxin could improve left ventricular ejection fraction in rats with heart failure; Compared to the model group, captopril Left ventricular EF value increased, but there was not significant. At week four,heart failure and left ventricular EF values was improved in the intervention group and the other four captopril drug intervention. At week one in the rats with drug intervention, the medicinals of Yi qi, Wen yang plus Yi qi, and captopril could inhibit activation in vivo hormone aldosterone in heart failure rats; aldosterone in Wen yang group and digoxin group were not different from that in the model group at week two and ***: Chinese medicinals with properties of Wen yang, Yi qi have significant effect on improving left ventricular EF in rats with heart failure; compared to Yi qi medicinals, Wen yang medicinals that inhibit the effectiveness of the time

关键词： warming yang,reinforcing qi Heart failure Stroke volume Aldosterone

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