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Chemical constituents from the aerial parts of waltheria indica Linn.

Journal of Chinese Pharmaceutical Sciences 2019年第7期28卷 468-475页

作者： Yiming Hua Xiaowen Zhang Kewu Zeng Qingying Zhang Pengfei Tu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

A phytochemical investigation on the aerial parts of waltheria indica *** to the isolation of 16 compounds,including five terpenoids(1–5),four coumarins(6–9),six flavonoids(10–15),and one phenylpropanoid glycoside(16).The structures of these compounds were identified by spectroscopic data analysis and comparison with those reported in the *** for 12 and 15,all the compounds were isolated from *** for the first ***,coumarins were firstly reported to be obtained from this *** NO production inhibitory activities of all the isolated compounds in LPS-induced BV-2 cells were also presented.

关键词： waltheria indica Terpenoids Flavonoids Coumarins NO production inhibitory activities

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GC-MS and NMR analysis of the bioactive compounds from the crude extracts of waltheria indica and the histopathological changes induced in albino rats challenged with Naja nigricollis venom

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Journal of Coastal Life Medicine 2016年第5期4卷 395-402页

作者： Philip Ilani Nicholas Ajodo Folashade Adewusi Samirat Yakubu Victor Yakubu Cosmos Ache Eunice Atonila Kayode Ezekiel Oshiedu Sarah Emmanuel Amlabu Department of Biochemistry Kogi State UniversityAnyigbaNigeria

Objective:To develop a characteristic fingerprint of the different chemical compounds of plant by gas chromatography-mass spectrometer(GC-MS)and nuclear magnetic resonance(NMR)analysis and assess the effect of the crude extract on histological changes induced in Naja nigricollis(***)envenomed albino ***:The coarsely powdered waltheria indica(***)whole plant material was extracted using 70%***-MS analysis was carried out using a Shimadzu GC-MS QP 2010 plus system of gas chromatography interfaced to a mass *** identification of components was based on National Institute of Standard and Technology-08 and Willey-8 ***-NMR spectra of the extracts was performed using Bruker Biospin Avance 400-MHz NMR spectrophotometer with a 5 mm broad inverse probe head,equipped with shielded z-gradient accessories and C-13 NMR hetero-nuclear single quantum correction was carried out using the Brucker’s standard pulse *** efficacy of the crude extract of *** whole plant was tested and the lesions induced in the liver,brain and kidney of albino rats challenged with *** were analyzed by light ***:The identification of the bioactive compounds from *** by GC-MS analysis revealed 41 peaks.A total of 38 compounds were identified with majority having important pharmacological activities that included anti-microbial,anti-cancer,anti-oxidant antiinflammatory,anti-allergenic,anti-ageing,anti-arthritic,larvicidal,anti-convulsant and herbicidal activities.C-13 and hydrogen-NMR analysis of *** elucidated key bioactive compounds in the whole plant that were consistent with the classes of bioactive compounds detected by GC-MS *** efficacy of the crude extract of *** whole plant in ameliorating histopathological lesions induced in the liver,brain and kidney of albino rats challenged with *** venom revealed the abrogation of tissue degeneration when compared with the experim

关键词： waltheria indica Gas chromatography-mass spectrometer Nuclear magnetic resonance Bioactive compounds Pharmacological activities Web-based analysis Naja nigricollis venom Histopathology

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