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Sulfation of chondroitin and bile acids converges to antagonize wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

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Acta Pharmaceutica Sinica b 2024年第3期14卷 1241-1256页

作者： Pengfei Xu Yue Xi Jong-Won Kim Junjie Zhu Min Zhang Meishu Xu Songrong Ren Da Yang Xiaochao Ma Wen Xie Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261USA Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Pharmacology&Chemical biology University of PittsburghPittsburghPA 15261USA

Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology.3’-Phosphoadenosine 5’-phosphosulfate(PAPS)synthase 2(PAPSS2)is the primary enzyme to generate the universal sulfonate donor *** involvement of PAPSS2-mediated sulfation in adenomatous polyposis coli(APC)mutation-promoted colonic carcinogenesis has not been ***,we showed that the expression of PAPSS2 was decreased in human colon tumors along with cancer stages,and the lower expression of PAPSS2 was correlated with poor prognosis in advanced colon *** epithelial-specific heterozygous Apc deficient and Papss2-knockout(Apc^(Δgut-Het)Papss2^(Δgut))mice were created,and the phenotypes were compared to the spontaneous intestinal tumorigenesis of Apc^(Δgut-Het)***^(Δgut-Het)Papss2^(Δgutmice) were more sensitive to gut tumorigenesis,which was mechanistically accounted for by the activation of wnt/β-catenin signaling pathway due to the suppression of chondroitin sulfation and inhibition of the farnesoid X receptor(FXR)-transducin-like enhancer of split 3(TLE3)gene regulatory *** sulfate supplementation in Apc^(Δgut-Het)Papss2^(Δgutmice) alleviated intestinal *** summary,we have uncovered the protective role of PAPSS2-mediated chondroitin sulfation and bile acids-FXR-TLE3 activation in the prevention of gut carcinogenesis via the antagonization of wnt/β-catenin *** sulfate may be explored as a therapeutic agent for Papss2 deficiency-associated colonic carcinogenesis.

关键词： Colon cancer APC wnt/b-catenin PAPSS2 Chondroitin sulfate Sulfation bile acids FXR

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TRIM28 protects CARM1 from proteasome-mediated degradation to prevent colorectal cancer metastasis

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Science bulletin 2019年第14期64卷 986-997页

作者： Jinyuan Cui Jia Hu Zhilan Ye Yongli Fan Yuqin Li Guobin Wang Lin Wang Zheng Wang Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Research Center for Tissue Engineering and Regenerative Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

TRIM28(Tripartite motif-containing protein 28), a member of TRIM family, is aberrantly expressed and reportedly has different functions in many types of human cancer. However, the biological roles of TRIM28 and related mechanism in colorectal cancer(CRC) remain unclear. Here, we showed that TRIM28 was downregulated in colorectal cancer compared with normal mucosa, especially at advanced stages, and acted as an independent prognostic factor of favorable outcome. Functional studies demonstrated that TRIM28 restrained CRC migration and invasion in vitro and in vivo. Mechanistically, we reported that CARM1(co-activator-associated arginine methyltransferase1) was a critical player downstream of TRIM28. TRIM28 interacted with CARM1, and protected CARM1 from proteasome-mediated degradation through physical protein-protein interaction to suppress CRC metastasis. Further, TRIM28 suppressed the migration and invasion of CRC cells through inhibiting wnt/b-catenin signaling in a CARM1-dependent manner, but independent of CARM10 s methyltransferase activity. The protein expression of CARM1 was positively correlated with TRIM28 in CRC tissues. Patients with high levels of TRIM28 and CARM1 had improved prognosis, whereas patients with low TRIM28 and CARM1 expression had the poor outcomes. Thus, our study reveals an inhibitory role of TRIM28 in CRC metastasis, which was achieved through a TRIM28-CARM1-wnt/b-catenin axis. This work provides potential prognostic and therapeutic targets for CRC treatment.

关键词： Colorectal cancer Metastasis TRIM28 CARM1 Ubiquitination wnt/b-catenin

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Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways in liver tumors: a review

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Acta Pharmaceutica Sinica b 2020年第1期10卷 113-122页

作者： Albert braeuning Michael Schwarz German Federal Institute for Risk Assessment Dept.Food SafetyBerlin 10589Germany Eberhard Karls University of Tu¨bingen Inst.of Pharmacology and ToxicologyDept.of ToxicologyTu¨bingen 72074Germany

Mutations in genes encoding key players in oncogenic signaling pathways trigger specific downstream gene expression profiles in the respective tumor cell *** regulation of genes related to cell growth,survival,and death has been extensively studied,much less is known on the regulation of drug-metabolizing enzymes(DMEs)by oncogenic ***,a comprehensive review of the available literature is presented summarizing the impact of the most relevant genetic alterations in human and rodent liver tumors on the expression of DMEs with a focus on phasesⅠandⅡof xenobiotic *** few data are available with respect to DME regulation by p53-dependent signaling,telomerase expression or altered chromatin *** contrast,DME regulation by constitutive activation of oncogenic signaling via the RAS/RAF/mitogen-activated protein kinase(MAPK)cascade or via the canonical wnt/β-catenin signaling pathway has been analyzed in greater depth,demonstrating mostly positive-regulatory effects of wnt/β-catenin signaling and negativeregulatory effects of MAPK *** studies have revealed molecular interactions between oncogenic signaling and nuclear xeno-sensing receptors which underlie the observed alterations in DME expression in liver *** of altered DME expression and inducibility in liver tumors with a specific gene expression profile may impact pharmacological treatment options.

关键词： Xenobiotic metabolism Hepatocytes wnt/b-catenin signaling RAS/MAPK signaling Gene mutation Cytochrome P450

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Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

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Genes & Diseases 2024年第5期11卷 198-218页

作者： Han Sun Yafang Gao Xinyu Ma Yizhou Deng Lintao bi Lisha Li Department of Hematology and Oncology China-Japan Union HospitalJilin UniversityChangchunJilin 130021China The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchunJilin 130021China

Mechanical stimulation is the key physical factor in cell *** acts as a fundamental regulator of cell behavior,regulating cell proliferation,differentiation,apoptosis,and exhibiting specific signature alterations during the pathological *** research continues,the role of epigenetic science in mechanotransduction is attracting ***,the molecular mechanism of the synergistic effect between mechanotransduction and epigenetics in physiological and pathological processes has not been *** focus on how histone modifications,as important components of epigenetics,are coordinated with multiple signaling pathways to control cell fate and disease ***,we propose that histone modifications can form regulatory feedback loops with signaling pathways,that is,histone modifications can not only serve as downstream regulators of signaling pathways for target gene transcription but also provide feedback to regulate signaling *** and epigenetic changes could be potential markers and therapeutic targets in clinical practice.

关键词： FAK Histone modifications MAPK Mechanotransduction RhoA wnt/b-catenin YAP/TAZ

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Cell osteogenic bioactivity mediated precisely by varying scaled micro-pits on ordered micro/nano hierarchical structures of titanium

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Regenerative biomaterials 2022年第1期9卷 597-611页

作者： Yanmei Zhang Xiankuan Wang Yaxian Li Jianhe Liang Pinliang Jiang Qiaoling Huang Yun Yang Hongping Duan Xiang Dong Gang Rui Changjian Lin State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Research Institute for biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Functional Materials ResearchCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China beijing Engineering Laboratory of Functional Medical Materials and Devices Beijing Medical Implant Engineering Research CenterBeijing Naton Technology Group Co.LtdBeijingChina Department of Orthopedics Surgery The First Affiliated Hospital of Xiamen UniversityXiamenFujian 361003China Tan Kah Kee Innovation Laboratory XiamenFujian 361005China

Hierarchical surface structures with micro–nano scale play a crucial role in regulation of cell proliferation and osteogenic *** has been proven that cells are extremely sensitive to the nanoscaled structure and show multifarious *** a vital function of microstructure on osseointegration has been confirmed,the cell performances response to different microscaled structure is needed to be further dissected and in depth *** this work,the ordered micro–nano hierarchical structures with varying micro-scaled pits were precisely fabricated on titanium successfully by the combination of electrochemical,chemical etching and anodization as *** vitro systematical assessments indicated that the micro–nano multilevel structures on titanium exhibited excellent cells adhesion and spreading ability,as well as steerable proliferation and osteogenic differentiation *** is shown that smaller micro-pits and lower roughness of the hierarchical structures enabled faster cell *** cell growth was delayed on micro–nano titanium with relatively larger cell-match-size micro-pits and roughness,osteogenic-specific genes were significantly ***,the alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization of MC3T3-E1 on multiscaled titanium were suppressed by a large margin after adding IWP-2(an inhibitor of wnt/b-catenin signal pathway),indicating this pathway played a crucial part in cell osteogenic differentiation modulated by micro–nano structures.

关键词： electrochemical self-organizing etching varying micro-scaled pits osteogenic wnt/b-catenin

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wnt versus Hippo:A balanced act or dynamic duo?

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Genes & Diseases 2014年第2期1卷 127-128页

作者： Zhongliang Wang Jixing Ye Youlin Deng Zhengjian Yan Sahitya Denduluri Tong-Chuan He Molecular Oncology Laboratory The University of Chicago Medical CenterChicagoIL 60637USA

The Hippo signaling pathway was first discovered in Drosophila as a conserved regulator of organ *** inactivation in mice demonstrates that the Hippo pathway functions as a fundamental inhibitor of organ growth during... 详细信息

关键词： β-TrCP Destruction complex Hippo Proteasome degradation Signal transduction wnt/b-catenin YAP/TAZ

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EGCG对肾缺血再灌注损伤的保护作用及其作用机制的研究

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茶叶科学 2016年第2期36卷 169-174页

作者：刘洪国潍坊医学院人体解剖学教研室山东潍坊261053

探讨了表没食子儿茶素没食子酸酯(EGCG)对大鼠肾缺血再灌注损伤的保护作用及其机制。结果表明,与肾缺血再灌注损伤模型组相比,EGCG组肾功能改善,肾组织病理改变,wnt3a、?-catenin、p53、p21、MDA、IL-6、IFN-?和TNF-?表达明显减少,而CAT... 详细信息

探讨了表没食子儿茶素没食子酸酯(EGCG)对大鼠肾缺血再灌注损伤的保护作用及其机制。结果表明,与肾缺血再灌注损伤模型组相比,EGCG组肾功能改善,肾组织病理改变,wnt3a、?-catenin、p53、p21、MDA、IL-6、IFN-?和TNF-?表达明显减少,而CAT,GPX和SOD表达明显增加。说明EGCG预处理减轻肾缺血再灌注损伤与抑制wnt3a/?-catenin/p53信号通路介导的炎症反应和氧化应激相关。

关键词：表没食子儿茶素没食子酸酯肾缺血再灌注损伤炎症氧化应激 wnt/b-catenin

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