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Alpha Defensins Genes and vulvovaginal candidiasis:A Study of Cases

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Open Journal of Obstetrics and Gynecology 2015年第9期5卷 487-493页

作者： Humberto F Boatto Elaine C.Francisco Joao P.Kleine Ismael D.Silva Manoel J.B.C.Girao Alexandre P.Machado Olga Fischman Medical Clinic Department Medical FacultyUniversity of Mogi das CruzesMogi das CruzesBrazil Mycology Laboratory MicrobiolologyImmunology and Parasitology DepartmentFederal University of Sao PauloSao PauloBrazil Gynecology Department Federal University of Sao PauloSao PauloBrazil Molecular Oncology Research Center Barretos Cancer HospitalPio XII FoundationBarretosBrazil Microbiology Laboratory of Health Basic Sciences Department Medical FacultyFederal University of Mato GrossoCuiabáBrazil

Objective: To evaluate the alpha-defensin (α-DF) genes polymorphism in women with vulvovaginal candidiasis and recurrence. Methods: This observational study included clinical vaginal secretion samples collected over four years from 88 women, ranging in age from 18 to 65 years, from medical centers of Sao Paulo and Mogi das Cruzes, Brazil. Thirty-six of these women were asymptomatic (control group) and 52 presented clinical condition compatible with vulvovaginitis (38 primary or episodic as non-recurrent forms, and 14 recurrent vulvovaginal candidiasis). A portion of each sample was plated on Sabouraud dextrose agar with chloramphenicol and grown on CHROMagar Candida for presumptive characterization. The identification of the species was obtained by sequencing of the ITS1 region of rDNA. α-DF genes were amplified for subsequent evaluation of polymorphisms by endonuclease restriction assay. Results: From 88 samples were isolated 60 Candida albicans and 28 non-albicans Candida spp. Resistant C. albicans strains and non-albicans Candida spp. were more prevalent in recurrence. In all groups, the number of resistant non-albicans Candida spp. was most high than susceptible strains. α-DF1, α-DF3 and α-DF1/α-DF3 genotypes were found in 32 (36.4%), 17 (19.3%), 6 (6.8%) vaginal samples, respectively. About 33 samples were not amplified. Recurrence and severe disease were more observed in homozygous population. Conclusions: Non-albicans Candida spp. and homozygotic α-DF genotipes (α-DF1 and α-DF3) were more related with severe clinical signs and recurrence. Further studies about vulvovaginal candidiasis and α-DF genes are necessary to access the more comprehensive role of defensins in clinical manifestations.

关键词： Alpha-Defensin Genes Candida albicans Non-Albicans Candida vulvovaginal candidiasis Recurrent vulvovaginal candidiasis

Determining the Prevalence of Bacterial Vaginosis &vulvovaginal candidiasis among Married and Unmarried Women &Evaluating the Association Socio-Demographic Risk Factors &Symptoms-Related Variables in Women Attending Gynecology Clinic in Hargeisa Group Hospital, Hargeisa City, Somaliland

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Open Journal of Medical Microbiology 2020年第3期10卷 114-128页

作者： Abdullah Al-Mamari Faculty of Medicine & Health Science Hargeisa University Hargeisa Somaliland Afrika Aktive and the EKF-Stiftung Germany

Background: Vaginitis refers to any inflammation or infection of the vagina. This is a common gynecological problem found in women of all ages, with one-third of women having at least one form of vaginitis at some time during their lives. The vagina is the muscular passageway between the uterus and the external genital area. When the walls of the vagina become inflamed, because some irritant has disturbed the balance of the vaginal area, vaginitis can occur. The most common types of vaginitis are: Candida or “yeast” infection, Bacterial vaginosis, Trichomoniasis vaginitis. Objectives of Study: Therefore, the present study was carried out to determine the prevalence of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC) among married and unmarried women and evaluate the association socio-demographic risk factors and symptoms-related variables in women attending gynecology clinic in Hargeisa group hospital. Methodology: A total of 150 married and unmarried women were investigated & diagnosed by a researcher in Hargeisa Group Hospital, Hargeisa City, Somaliland for determining of VVI prevalence in the present study. Vaginal swabs from these patients were processed for detection of bacterial vaginosis (BV), VVC and trichomoniasis based on guidelines

关键词： vulvovaginal candidiasis Bacterial Vaginosis Women Prevalence

Comparison of Vaginal Flora in Patients with Spontaneous Abortion and Women with Normal First-Trimester

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Reproductive and Developmental Medicine 2018年第3期2卷 150-156页

作者： Xiao-Li Liu Yi Xiao Hong Zhang Li-Juan Wu Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow UniversitySoochowChina

Objective: The effect of alterations in vaginal flora during pregnancy remains uncertain. We compared the flora distribution in women with spontaneous abortion(SA) and those in normal ***: Samples of vaginal discharge were obtained from 3,233 women attending the Gynecological and Public Health Centre of our hospital from January 2010 to December 2013. Pathogen culture testing was performed by the Microbiological Diagnostic Centre of our hospital, including SA group(n= 1,513), normal first-trimester group(NP group, n = 908), and nonpregnant women(control group, n= 812).Results: Of 3,233 vaginal discharge samples, 425 samples(13.15%) were positive for pathogen. The pathogen detection rate was19.96%(302/1,513), 7.93%(72/908), and 6.28%(51/812) in the SA, NP, and control groups, respectively. The five most common bacteria were Enterococcus faecalis, Candida albicans, Escherichia coli, group B Streptococcus(GBS), and Ureaplasma urealyticum(Uu) in the SA group; Uu, C. albicans, Candida tropicalis, GBS, and *** in the NP group; and Candida glabrata, Uu, E. coli, Gardnerella vaginalis,and C. albicans in the control ***: In the SA group, the pathogen detection rate was markedly elevated. An infection of Candida sp. in pregnant women was relatively common. In routine antenatal care, overtreatment is not recommended in asymptomatic candidiasis. There was no significant difference in the detection rate of Uu between the SA group and the other two groups, suggesting that it does not cause SA.

关键词： Bacterial Vaginosis Pregnancy Spontaneous Abortion Vaginal Infection vulvovaginal candidiasis

Clinical Experience in the Treatment of vulvovaginal Candida Disease with Integrated Traditional Chinese and Western Medicine

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Journal of Clinical and Nursing Research 2021年第4期5卷 110-112页

作者： Xiaodan Yang Jie Wang Zhenzhen Jia Lihong Zhu Shaanxi University of Traditional Chinese Medicine Xianyang 712000Shaanxi ProvinceChina The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine Xianyang 712000Shaanxi ProvinceChina

Summarizing two cases of vaginal candidiasis,cured by integrated traditional Chinese and western medicine in clinical work,it is found that the combination of traditional Chinese and western medicine has a significant effect on the treatment of this *** curative effect is outstanding,and the recurrence rate is significantly reduced,which can be used as a reference for gynecological medical workers.

关键词： Integrated traditional Chinese and western medicine vulvovaginal candidiasis Syndrome differentiation and treatment