检索结果-南通市图书馆

Theoretical and simulation studies on voltage-gated sodium channels

Protein & Cell 2015年第6期6卷 413-422页

作者： Yang Li Haipeng Gong MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China

voltage-gated sodium （Nav） channels are indispensable membrane elements for the generation and propagation of electric signals in excitable cells. The successes in the crystallographic studies on prokaryotic Nay chan- nels in recent years greatly promote the mechanistic investigation of these proteins and their eukaryotic counterparts. In this paper, we mainly review the pro- gress in computational studies, especially the simula- tion studies, on these proteins in the past years.

关键词： voltage-gated sodium channels,molecular dynamics simulation ion permeation ionselectivity voltage gating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Major vacuolar TPC1 channel in stress signaling:what matters,K^(+),Ca^(2+) conductance or an ion‑flux independent mechanism?

引用

Stress Biology 2022年第1期2卷 312-323页

作者： Igor Pottosin Oxana Dobrovinskaya Biomedical Center University of Colima28045 ColimaMexico International Research Centre for Environmental Membrane Biology Foshan UniversityFoshan 528041China

Two-pore cation channel,TPC1,is ubiquitous in the vacuolar membrane of terrestrial plants and mediates the long distance signaling upon biotic and abiotic *** possesses a wide pore,which transports small mono-and divalent cations.K^(+) is transported more than 10-fold faster than Ca^(2+) ,which binds with a higher affinity within the *** pore residues,responsible for Ca^(2+) binding,have been recently *** is also a substantial pro-gress in the mechanistic and structural understanding of the plant TPC1 gating by membrane voltage and cytosolic and luminal Ca^(2+).Collectively,these gating factors at resting conditions strongly reduce the potentially lethal Ca^(2+) leak from the *** tight control is impressive,bearing in mind high unitary conductance of the TPC1 and its abundance,with thousands of active channel copies per *** it remains a mystery how this high thresh-old is overcome upon signaling,and what type of signal is emitted by TPC1,whether it is Ca^(2+)or electrical one,or a transduction via protein conformational change,independent on ion *** we discuss non-exclusive scenarios for the TPC1 integration into Ca^(2+),ROS and electrical signaling.

关键词： TPC1 Potassium Calcium voltage gating Long-distance signaling Vacuole

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ferroelectricity in biological building blocks:Slipping on a banana peel?

引用

Journal of Advanced Dielectrics 2023年第4期13卷 60-64页

作者： Syed A.M.Tofail Department of Physics and Bernal Institute University of Limerick National Technological ParkIreland

Ferroelectricity in biological system has been anticipated both theoretically and experimentally over the past few *** of ferroelectricity in biological systems have given rise to confusion and methodological *** the years,a“loop”of induced polarization in response to a varying applied electrical field and a consequent polarization reversal has prompted many researchers to claim ferroelectricity in biological structures and their building *** observers were skeptical about the methodology adopted in generating the data and questioned the validity of the claimed ferroelectricity as such,“loop”can also be obtained from linear *** a paper with somewhat tongue-in-cheek title,Jim Scott showed that ordinary banana peels could exhibit closed loops of electrical charge which closely resemble and thus could be misinterpreted as ferroelectric hysteresis loops in barium sodium niobate,BNN paraphrasing it as“banana”.In this paper,we critically review ferroelectricity in biological system and argue that knowing the molecular and crystalline structure of biological building blocks and experimenting on such building blocks may be the way forward in revealing the“true”nature of ferroelectricity in biological systems.

关键词： Ferroelectricity piezoelectricity pyroelectricity biological materials ion channel voltage gating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：